Aging, cancer, and autophagy: connections and therapeutic perspectives DOI Creative Commons

Begoña Zapatería,

Esperanza Arias

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 28, 2025

Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy progression age-related decline. As organisms age, cellular stress, genomic instability, an accumulation senescent cells create a pro-inflammatory environment conducive to development. Autophagy, process responsible for degrading recycling damaged components, plays pivotal role in this relationship. While autophagy acts as tumor-suppressive mechanism by preventing organelles proteins, often exploit it survive under conditions metabolic stress treatment resistance. The interplay between aging, cancer, reveals key insights into tumorigenesis, senescence, proteostasis dysfunction. This review explores connections these processes, emphasizing potential autophagy-targeted therapies strategies could be further explored aging treatment. Understanding dual roles suppressing promoting offers promising avenues therapeutic interventions aimed at improving outcomes elderly patients while addressing deterioration.

Language: Английский

Hallmarks of aging: An expanding universe DOI Creative Commons
Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

Citations

2854
Mitochondrial dysfunction: mechanisms and advances in therapy DOI Creative Commons

Zong Yao,

Hao Li, Peng Liao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 15, 2024

Abstract Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation disease progression. Particularly, mitochondrial dysfunctions identified many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, cancer. However, the multifaceted nature elusive phenotypic threshold dysfunction complicate our understanding contributions to diseases. Nonetheless, these complexities do not prevent mitochondria from being among most important therapeutic targets. In recent years, strategies targeting have continuously emerged transitioned clinical trials. Advanced intervention such as using healthy replenish or replace damaged mitochondria, has shown promise preclinical trials various Mitochondrial components, mtDNA, mitochondria-located microRNA, associated proteins can be potential agents augment function immunometabolic diseases tissue injuries. Here, we review current knowledge pathophysiology concrete examples We also summarize treat perspective dietary supplements targeted therapies, well translational situation related pharmacology agents. Finally, this discusses innovations applications transplantation an advanced promising treatment.

Language: Английский

Citations

239
Aging Hallmarks and the Role of Oxidative Stress DOI Creative Commons
Edio Maldonado, Sebastián Morales, Fabiola Urbina

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 651 - 651

Published: March 6, 2023

Aging is a complex biological process accompanied by progressive decline in the physical function of organism and an increased risk age-related chronic diseases such as cardiovascular diseases, cancer, neurodegenerative diseases. Studies have established that there exist nine hallmarks aging process, including (i) telomere shortening, (ii) genomic instability, (iii) epigenetic modifications, (iv) mitochondrial dysfunction, (v) loss proteostasis, (vi) dysregulated nutrient sensing, (vii) stem cell exhaustion, (viii) cellular senescence, (ix) altered communication. All these alterations been linked to sustained systemic inflammation, mechanisms contribute timing not clearly determined yet. Nevertheless, dysfunction one most important contributing process. Mitochondria primary endogenous source reactive oxygen species (ROS). During ATP production elevated ROS together with antioxidant defense. Elevated levels can cause oxidative stress severe damage cell, organelle membranes, DNA, lipids, proteins. This contributes phenotype. In this review, we summarize recent advances emphasis on production.

Language: Английский

Citations

211
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

203
ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways DOI Creative Commons
Arthur José Pontes Oliveira de Almeida, Júlio César Pinheiro Lúcio de Oliveira,

Larisse Virgolino da Silva Pontes

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Language: Английский

Citations

161
Mitochondrial dysfunction in aging DOI
Ying Guo, Teng Guan,

Kashfia Shafiq

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101955 - 101955

Published: May 15, 2023

Language: Английский

Citations

142
Hallmarks of cardiovascular ageing DOI
Mahmoud Abdellatif, Peter P. Rainer, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 20(11), P. 754 - 777

Published: May 16, 2023

Language: Английский

Citations

122
Dietary regulation in health and disease DOI Creative Commons
Qi Wu,

Zhijie Gao,

Xin Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 23, 2022

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.

Language: Английский

Citations

101
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases DOI Creative Commons
Qian Lu, Yanli Zhu, Chao Deng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 1, 2024

Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac diseases cardiovascular neurological disorders, kidney motor system metabolic disorders. Examining the upstream modulators co-activated partners identifying critical biological events modulated by downstream effectors contribute to presentation elaborate network PGC-1s. Furthermore, discussing correlation between well summarizing therapy targeting helps make individualized precise intervention methods. In this review, we summarize basic knowledge regarding molecular regulatory network, discuss physio-pathological roles human review application PGC-1s, diagnostic prognostic value several therapies pre-clinical studies, suggest directions for future investigations. This presents immense potential treatment hopefully facilitates promotion new therapeutic targets.

Language: Английский

Citations

81
Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid DOI Creative Commons
Junli Ma,

Zekun Liu,

Xinxin Gao

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 189, P. 106687 - 106687

Published: Feb. 4, 2023

Accumulating evidence indicates gut microbiota contributes to aging-related disorders. However, the exact mechanism underlying dysbiosis-related pathophysiological changes during aging remains largely unclear. In current study, we first performed remodeling on old mice by fecal transplantation (FMT) from young mice, and then characterized bacteria signature that was specifically altered FMT. Our results revealed FMT significantly improved natural systemic disorders, particularly exerted hepatoprotective effects, glucose sensitivity, hepatosplenomegaly, inflammaging, antioxidative capacity intestinal barrier. Moreover, increased abundance of A.muciniphila, which almost nondetectable in mice. Interestingly, A.muciniphila supplementation also similar benefits with Notably, targeted metabolomics short chain fatty acids (SCFAs) only acetic acid consistently reversed Then, intervention beneficial actions both Caenorhabditis elegans conclusion, our study demonstrated disorders through its derived acid, suggesting interventions potent stimulative A. muciniphila growth production alternative effective way maintain healthy aging. The data RNAseq 16 S rRNA gene sequencing can be accessed NCBI accession number PRJNA848996 PRJNA849355.

Language: Английский

Citations

77