Cited by Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease

Mitochondrial function and gastrointestinal diseases DOI

Parsa Haque,

Neeraj Kapur, Terrence A. Barrett

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 537 - 555

Published: May 13, 2024

Language: Английский

Citations

Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum DOI

Miaomiao Li, Xue Han, Lijun Sun

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 25, 2024

Background Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence IBD driven complex interactions multiple factors. objective this study was to evaluate therapeutic effects IAA in colitis.

Language: Английский

Citations

Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease DOI

Janet O’Sullivan,

Shriram Patel, Gabriel E. Leventhal

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 15, 2025

Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury environmental influences, most appear to act via gut microbiome. We hypothesized that host-microbe alterations could be used prognostically stratify patients experiencing relapses up four years after endoscopy. therefore examined multiple omics data, including published new datasets, generated from paired inflamed non-inflamed mucosal biopsies 142 with IBD (54 CD; 88 UC) 34 control (non-diseased) biopsies. The relapse-predictive potential 16S rRNA gene transcript amplicons (standing active microbiota) were investigated along host transcriptomics, epigenomics genetics. While standard single-omics analysis not distinguish between who relapsed those remained in remission within colonoscopy, we did find an association number flares a patient's succinotype. Our multi-omics machine learning approach was also able predict relapse when combining features microbiome human host. Therefore multi-omics, rather than single omics, better predicts 4 while succinotype associated higher frequency relapses.

Language: Английский

Citations

Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects DOI

Alexandra Noble, Jan Krzysztof Nowak, Alex Adams

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 165(1), P. 44 - 60.e2

Published: April 14, 2023

Language: Английский

Citations

Validity of Inflammatory Bowel Disease Diagnoses in the Danish National Patient Registry: A Population-Based Study from the North Denmark Region DOI

Henrik Jacobsen, Tine Jess, Lone Larsen

et al.

Clinical Epidemiology, Journal Year: 2022, Volume and Issue: Volume 14, P. 1099 - 1109

Published: Oct. 1, 2022

The Danish National Patient Registry (DNPR) is recognized for providing high-quality data. However, only a few minor studies have validated inflammatory bowel disease (IBD) diagnoses in the DNPR, reporting various degrees of validity. To pave way large-scale IBD Denmark, we aimed to investigate validity among >8000 patients registered DNPR between 2002 and 2020 North Denmark Region.To evaluate reliability initially compared all with one diagnosis during 2002-2020 list already verified regional database GASTROBIO. Medical records on not were manually reviewed by gastroenterologist verify or dismiss diagnosis. Positive predictive values (PPV) calculated.Of 8040 at least 5263 confirmed cases, leaving 2777 medical record evaluation, whom 849 had IBD. In total, 6112 correctly based diagnosis, 1343 incorrectly registered, resulting PPV 0.82 (95% CI, 0.81-0.83). For two diagnoses, was 0.95 0.95-0.96), three 0.98 0.98-0.99). Results similar UC CD separately. Of note, completeness valid cases went from 4606 (75%; 95% 74%-76%) when demanding 3320 (54%; 53%-56%) diagnoses.Reassuringly, high, especially more than once. reduced applying true case definition should be considered.

Language: Английский

Citations

The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations DOI

Tianyu Zhou, Wenzhou Xu, Qiqi Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 27, 2023

Periodontitis and inflammatory bowel diseases (IBD) are of the gastrointestinal tract that share common features microbial-induced ecological dysregulation host immune response. The close relationship between periodontitis IBD is characterized by a higher prevalence in patients with severity IBD, indicating different from traditional independent form an “Oral-Gut” axis two, which affect each other thus vicious circle. However, specific mechanisms leading to association two not fully understood. In this article, we describe interconnection terms microbial pathogenesis dysregulation, including ectopic colonization gut pathogenic bacteria associated promotes inflammation activating response, alteration oral microbiota due affects periodontal Among factors, such as Klebsiella , Porphyromonas gingivalis Fusobacterium nucleatum may act bridge while among mechanisms, Th17 cell responses secreted pro-inflammatory factors IL-1β, IL-6 TNF-α play key role development both diseases. This suggests future studies, can look for targets control intervene regulating or intestinal flora through immunological methods.

Language: Английский

Citations

Effects of four food hydrocolloids on colitis and their regulatory effect on gut microbiota DOI

Shanshan Zhang,

Yonggan Sun,

Qixing Nie

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121368 - 121368

Published: Sept. 9, 2023

Language: Английский

Citations

Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways DOI

Kristina A. Dvornikova, Olga N. Platonova, E. Yu. Bystrova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2425 - 2425

Published: Jan. 26, 2023

The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can characteristic both normal and pathological conditions. Hypoxia-inducible factors (HIF) play key role in mediating response to hypoxia, they are tightly regulated by group enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss involvement inflammation signaling pathways pathogenesis inflammatory bowel disease (IBD) elaborate detail on multiple immune reactions during intestinal inflammation. We emphasize critical influence tissue microenvironment highlight existence overlapping functions responses mediated same molecular mechanisms. Finally, also provide an update development corresponding therapeutic approaches would useful for treatment or prophylaxis disease.

Language: Английский

Citations

Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease DOI

Yinfeng Zhang, Tingting Wang, Meng Sun

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 16, 2023

Abstract Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with variety of painful clinical manifestations an increased risk cancerization or death, has become emerging challenge to global healthcare due its rapidly increasing incidence. At present, there is no efficient cure against IBD because the elusive etiology pathogenesis IBD. Therefore, development alternative therapeutic strategies positive efficacy reduced side effects urgently needed. In recent years, great prosperity nanomedicine promoted by advanced nanomaterials redefining more attractive promising for owing their advantages in physiological stability, bioavailability, targeting sites. this review, firstly basic characteristics healthy intestinal microenvironments are presented. Then, different administration routes nanotherapeutics treatment reviewed. Subsequently, specific focus placed on introduction nanotherapeutic treatments based pathogenesis. Finally, some future challenges perspectives currently developed nanomedicines provided. It believed that above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry pharmaceutics.

Language: Английский

Citations

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis DOI

Shanshan Zhang,

Yonggan Sun,

Qixing Nie

et al.

Food Frontiers, Journal Year: 2023, Volume and Issue: 4(3), P. 1462 - 1471

Published: June 3, 2023

Abstract Polysaccharides are typically resistant to digestion in the gastrointestinal tract and instead degraded by gut microbiota colon. As such, they commonly employed as carriers for colon‐targeted drugs, with potential regulate microbiota. Pectin, carrageenan, guar gum, xanthan gum used polysaccharide carriers, but their degradation under colitis conditions well effects on remains unclear. In this study, we performed vitro fermentation of these four polysaccharides using colonic content from mice evaluated degree pH, short‐chain fatty acids, Our findings indicate that pectin had a greater promoted production butyrate, inhibited proliferation harmful bacteria (e.g., Enterobacteriaceae ), increased beneficial Bifidobacterium ). contrast, carrageenan promote . These results provide theoretical guidance selection drug delivery inflammatory bowel disease treatment information relationship between

Language: Английский

Citations