Noninvasive, microbiome-based diagnosis of inflammatory bowel disease

Nature Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

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Global, regional, and national burden of inflammatory bowel disease, 1990–2021: Insights from the global burden of disease 2021

International Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 7, 2024

Language: Английский

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Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 413 - 413

Published: Jan. 6, 2025

Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn’s disease ulcerative colitis, are multifactorial characterized by chronic inflammation of the tract. On other hand, IBS is one principal tract functional abdominal pain altered habits. Although precise etiopathogenesis these remains unclear, mounting evidence suggests that non-coding RNA molecules play crucial roles in regulating gene expression associated with inflammation, apoptosis, oxidative stress, tissue permeability, thus influencing progression. miRNAs have emerged possible reliable biomarkers, they can be analyzed biological fluids patients at a low cost. This review explores IBDs IBS, focusing on their involvement control hallmarks. By an extensive literature employing bioinformatics tools, we identified frequently studied concerning diseases. Ultimately, specific could proposed diagnostic biomarkers for IBS. Their ability to secreted into biofluids makes them promising candidates non-invasive tools. Therefore, understanding molecular mechanisms through ways which regulate immune responses provide new insights pathogenesis open avenues miRNA-based therapeutic interventions.

Language: Английский

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CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes is implicated the pathogenesis of IBD CRC. Circular RNAs (circRNAs) have gained attention for roles various diseases, including However, comprehensive understanding specific circRNAs involved CRC, functional lacking. Here, it found that circHIPK2 (hsa_circRNA_104507) bona fide circRNA consistently upregulated CRC suggesting its potential as biomarker. Furthermore, silencing suppressed growth cells vitro vivo. Interestingly, decreased circHipk2 potentiated dextran sulfate sodium (DSS)-induced colitis but alleviated colitis-associated tumorigenesis. Most significantly, mechanistic investigations further unveil circHIPK2, mediated by FUS, interacting with EIF4A3 to promote translation TAZ, ultimately increasing transcription downstream target genes CCN1 CCN2. Taken together, emerges key player shared mechanisms modulating pathway. CircHIPK2-EIF4A3 axis contributes intestinal epithelial enhancing TAZ translation.

Language: Английский

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Omics and Multi-Omics in IBD: No Integration, No Breakthroughs

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14912 - 14912

Published: Oct. 5, 2023

The recent advent of sophisticated technologies like sequencing and mass spectroscopy platforms combined with artificial intelligence-powered analytic tools has initiated a new era "big data" research in various complex diseases still-undetermined cause mechanisms. investigation these was, until recently, limited to traditional vitro vivo biological experimentation, but clear switch silico methodologies is now under way. This review tries provide comprehensive assessment state-of-the-art knowledge on omes, omics multi-omics inflammatory bowel disease (IBD). notion importance both health IBD introduced, followed by discussion the believed be relevant pathogenesis, how can generate insights translatable into useful clinical such as biomarker identification, prediction remission relapse, response therapy, precision medicine. pitfalls limitations current studies are critically analyzed, revealing that, regardless types omes being majority reports still based simple associations descriptive retrospective data from cross-sectional patient cohorts rather than more powerful longitudinally collected prospective datasets. Given this limitation, some suggestions provided may optimized for greater therapeutic benefit. concludes forecasting upcoming incorporation analyses routine management IBD.

Language: Английский

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The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 1, 2023

Inflammatory bowel disease (IBD) is becoming more common in the Western world due to changes diet-related microbial dysbiosis, genetics and lifestyle. Incidences of gut permeability can predate IBD continued barrier disruptions increase exposure bacterial antigens immune system thereby perpetuating chronic inflammation. Currently, most approved therapies target individual pro-inflammatory cytokines pathways. However, they fail approximately 50% patients their inability overcome redundant pro inflammatory responses. There increasing interest therapeutic potential T regulatory cells (Tregs) conditions widespread capability dampen inflammation, promote tolerance intestinal bacteria, facilitate healing mucosal ability be engineered for targeted therapy. Intestinal Treg populations are inherently shaped by dietary molecules microbiota-derived metabolites. Thus, understanding how these influence Treg-mediated preservation will provide insights into tolerance-mediated homeostasis. This review comprehensively explores interplay between diet, microbiota, influencing function attenuate progression colitis.

Language: Английский

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Organoids as regenerative medicine for inflammatory bowel disease

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110118 - 110118

Published: May 27, 2024

Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing activity relies on various pharmacological options. However, the effectiveness of current therapeutics limited and not universally applicable to all patients circumstances. Consequently, developing new management strategies necessary. Recent advances in endoscopically obtained intestinal biopsy specimens have highlighted potential epithelial organoid transplantation as novel therapeutic approach. Experimental studies using murine human transplantations shown promising outcomes, including tissue regeneration functional recovery. Human trials therapy commenced; thus, this article provides readers insights into necessity regenerative option clinical settings explores its associated challenges.

Language: Английский

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Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(7), P. 2143 - 2153

Published: June 12, 2024

Capsaicin, a pungent compound in chili peppers, is described as having potent anti-inflammatory, antioxidant, and antimicrobial properties. It also potential modulator of the immune system intestinal microbiota. Oral or rectal administration capsaicin has been studied to treat prevent colitis. However, those vias are often not well accepted due burning sensation that can cause. Our objective was evaluate whether application skin creams (0.075%) would be effective improving inflammation epithelial barrier function composition gut microbiota model mild colitis induced by dextran sulfate sodium (1.5%). The results showed cutaneous reversed weight loss decreased colon shortening diarrhea, all typical signs There an improvement barrier, preserving proteins from tight junctions. We evaluated biodistribution 99mtechnetium-radiolabeled (99mTc-CAPS) applied back animals. found significant concentrations 99 mTc-Cap small intestine after 2 4 h administration. In addition, there increased expression receptor TRPV1 colon. Moreover, animals with receiving presented better short-chain fatty acid profile levels SIgA, suggesting diversity. conclusion, our work opens avenues for further studies understand capsaicin's benefits mechanisms addressing through application.

Language: Английский

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Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammation

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, but molecular mechanisms underlying IBD are incompletely understood. In this study, we explored role and regulating mechanism otubain 2 (OTUB2), deubiquitinating enzyme, in IBD.

Language: Английский

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Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease

Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1570 - 1570

Published: Oct. 5, 2024

Inflammatory bowel disease (IBD) includes patients affected by Crohn's or ulcerative colitis. IBD is thought to be a chronic immune-mediated disease, but its origin remains elusive, and this limits new therapeutic approaches. Human endogenous retroviruses (HERVs) originate from ancestral infections represent 8% of the human genome. HERVs are no longer infectious, some retroviral sequences can activated, their aberrant expressions have been implicated in inflammatory autoimmune disorders. HERV transcription regulated TRIM28 SETDB1, which also directly involved epigenetic processes modulation immune response. Using PCR real-time Taqman amplification assay, we assessed, for first time, levels pol genes HERV-H, -K, -W families env syncytin 1 (SYN1), SYN2, HERV-W, as well SETDB1 whole blood 48 with (CD), 20 colitis (UC), healthy controls (HC) comparable age. The transcriptional HERV-H-pol (

Language: Английский

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