Fermented Astragalus and its metabolites regulate inflammatory status and gut microbiota to repair intestinal barrier damage in dextran sulfate sodium-induced ulcerative colitis DOI Creative Commons

Junxiang Li,

Yingchun Ma,

Xiaofeng Li

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 14, 2022

Fermentation represents an efficient biotechnological approach to increase the nutritional and functional potential of traditional Chinese medicine. In this study, Lactobacillus plantarum was used ferment medicine Astragalus, differential metabolites in fermented Astragalus (FA) were identified by ultra-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap mass spectrometry (UPLC-Q-Exactive-MS), ameliorating effect FA on dextran sulfate sodium (DSS)-induced colitis mice further explored. The results showed that 11 such as raffinose, progesterone uridine FA, which may help improve ability alleviate colitis. Prophylactic supplementation effectively improved DAI score, colon length histopathological lesion DSS-treated mice. abnormal activation intestinal immune barrier controlled after supplementation, contents myeloperoxidase (MPO) IgE reduced IgA increased. pro-inflammatory factors TNF-α, IL-1β, IL-6, IL-17 down-regulated anti-inflammatory IL-10 TGF-β up-regulated, suggesting can intervene inflammatory status regulating balance Th1/Th2/Th17/Treg related cytokines. addition, modified structure microbiota enriched abundance Akkermansia Alistipes, positively associated with production short-chain fatty acids. These microbes their induced also be involved maintaining mucosal integrity affecting immunity. We observed tight junction protein mucous secreting ZO-1, occludin, MUC2 genes expression more pronounced supplemented compared unfermented along modulation epithelial cells (IECs) apoptosis, verifying repaired FA. This study is first suggest a modulator regulate gut repair damage caused

Language: Английский

Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease DOI
Yuji Pu, Fan Xi, Zhuangzhuang Zhang

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 354, P. 1 - 18

Published: Dec. 27, 2022

Language: Английский

Citations

75
ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease DOI

Meiyu Bao,

Keyi Wang, Jingqiang Li

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 250 - 264

Published: March 1, 2023

Language: Английский

Citations

62
Understanding the therapeutic toolkit for inflammatory bowel disease DOI
Sophie Vieujean, Vipul Jairath, Laurent Peyrin‐Biroulet

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

4
Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis DOI Open Access

Christopher Capaldo

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8562 - 8562

Published: May 10, 2023

Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring inflammation of the intestinal mucosa, often with increasing severity over time. Life-long morbidities and diminishing quality life for IBD patients compel a search better understanding molecular contributors to disease progression. One unifying feature IBDs is failure gut form an effective barrier, core role intercellular complexes called tight junctions. In this review, claudin family junction proteins discussed as they fundamental component barriers. Importantly, expression and/or protein localization altered in IBD, leading supposition that barrier dysfunction exacerbates immune hyperactivity disease. Claudins large transmembrane structural constrain passage ions, water, substances between cells. However, growing evidence suggests non-canonical functions during mucosal homeostasis healing after injury. Therefore, whether claudins participate adaptive pathological responses remains open question. By reviewing current studies, possibility assessed claudins, jack-of-all-trades master none. Potentially, robust wound restitution involve conflicting biophysical phenomena, exposing vulnerabilities tissue-wide frailty IBD.

Language: Английский

Citations

25
Group 3 innate lymphoid cells in intestinal health and disease DOI
Veronika Horn, Gregory F. Sonnenberg

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(6), P. 428 - 443

Published: March 11, 2024

Language: Английский

Citations

14
Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling DOI Creative Commons

Zhilun Yu,

Ruiyang Gao,

Cheng Lv

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(7), P. 1451 - 1465

Published: March 15, 2024

Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading increased permeability. Current treatments of IBD primarily address neglecting epithelial repair. Our previous study has reported therapeutic potential notoginsenoside R1 (NGR1), a characteristic saponin from root Panax notoginseng, in alleviating acute colitis reducing mucosal inflammation. In this we investigated reparative effects NGR1 on after injury stage DSS exposure. DSS-induced mice were orally treated with (25, 50, 125 mg·kg

Language: Английский

Citations

12
Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review DOI
Chen Wang, Yu Gu, Qiao Chu

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127660 - 127660

Published: Feb. 28, 2024

Language: Английский

Citations

11
The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease DOI Creative Commons
Leilei Chen, Yan Wang, Huihui Zhou

et al.

Precision Clinical Medicine, Journal Year: 2024, Volume and Issue: 7(1)

Published: Jan. 8, 2024

Abstract Inflammatory bowel diseases (IBD), with an increasing incidence, pose a significant health burden. Although there have been advances in the treatment of IBD, more progress is still needed. Hyperbaric oxygen therapy (HBOT) has shown to treat host conditions such as carbon monoxide poisoning, decompression sickness, and gas gangrene. In last few years, increase research into use HBOT adjunct conventional for IBD. Related that may exert its therapeutic effects by decreasing oxidative stress, inhibiting mucosal inflammation, promoting ulcer healing, influencing gut microbes, reducing incidence IBD complications. This paper aims provide comprehensive review experimental clinical trials exploring supplement strategies.

Language: Английский

Citations

10
Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers DOI

Dingwei Li,

Jianxun Shangguan,

Fengnan Yu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(6), P. 7686 - 7699

Published: Jan. 30, 2024

The pathogenesis of ulcerative colitis (UC) is associated with the shedding gut mucus. Herein, inspired by biological functions mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment integrating dihydrocaffeic acid-modified poloxamer as a thermosensitive material hyaluronic acid (colitis-specific adhesive), epigallocatechin-3-gallate (antibacterial agent), and bioactive factors (KPV tripeptide epidermal factor). PHE-EK presented good properties, flowable liquid at room temperature gelled within 10 s when exposed to body temperature. mechanical strength strain 77.8%. Moreover, displayed antibacterial activity against Escherichia coli. Importantly, vitro vivo adhesive tests showed that could specifically adhere inflamed colon via electrostatic interaction. When biomimetic mucus rectally administrated rats, it effectively hindered weight loss, reduced disease index improved colonic shorting. expression pro-inflammatory cytokines (e.g., IL-1β, IL-6, TNF-α) laminae propria or epitheliums rats substantially inhibited PHE-EK. Besides, were well rearranged, tight junction proteins (Zonula-1 Claudin-5) between them greatly upregulated after treatment. Collectively, might be promising therapy UC.

Language: Английский

Citations

10
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation DOI Creative Commons
Annika Hausmann, Casper Steenholdt, Ole Haagen Nielsen

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(3), P. 239 - 251

Published: Feb. 5, 2024

The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the lumen. Barrier function is regulated by several pathways, its impairment contributes pathogenesis of inflammatory bowel disease (IBD), chronic condition affecting more than seven million people worldwide. Current treatment options specifically target mediators have led improvement clinical outcomes; however, significant proportion patients experience failure. Pro-repair effects on are emerging. In this review we summarize current knowledge involved epithelial identify open questions, put recent findings into perspective, pro-repair effects. A detailed understanding pathways integrating mucosal stimuli in homeostasis inflammation crucial for development novel, targeted therapies.

Language: Английский

Citations

10