The Journal of Immunology,
Journal Year:
2021,
Volume and Issue:
206(2), P. 257 - 263
Published: Jan. 1, 2021
Stromal
cells
have
for
a
long
time
been
viewed
as
structural
that
support
distinct
compartments
within
lymphoid
tissues
and
little
more.
Instead,
an
active
cross-talk
between
endothelial
fibroblastic
stromal
drives
the
maturation
of
niches,
relationship
is
recapitulated
during
lymph
node
organogenesis,
steady-state
conditions,
following
inflammation.
In
this
review,
we
go
over
recent
advances
in
genetic
models
high-resolution
transcriptomic
analyses
propelled
finer
resolution
cell
infrastructure
nodes,
revealing
subsets
are
strategically
positioned
to
deliver
catered
mixture
niche
factors
interacting
immune
populations.
Moreover,
discuss
how
changes
activation
state
poised
cell-underpinned
niches
rather
than
on-demand
differentiation
new
govern
efficient
interaction
Ag,
APC,
cognate
B
T
lymphocytes
adaptive
responses.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(1), P. 122 - 122
Published: Jan. 19, 2021
Since
the
2013
Nobel
Prize
was
awarded
for
discovery
of
vesicle
trafficking,
a
subgroup
nanovesicles
called
exosomes
has
been
driving
research
field
to
new
regime
understanding
cellular
communication.
This
exosome-dominated
traffic
control
system
increased
many
diseases,
including
cancer
metastasis,
diabetes,
and
HIV.
In
addition
important
diagnostic
role,
are
particularly
attractive
drug
delivery,
due
their
distinctive
properties
in
information
transfer
uptake.
Compared
viral
non-viral
synthetic
systems,
natural,
cell-derived
exhibit
intrinsic
payload
bioavailability.
Most
importantly,
easily
cross
biological
barriers,
obstacles
that
continue
challenge
other
delivery
nanoparticle
systems.
Recent
emerging
studies
have
shown
numerous
critical
roles
blood–brain
barrier
(BBB),
blood–cerebrospinal
fluid
(BCSFB),
blood–lymph
(BlyB),
blood–air
(BAB),
stromal
(SB),
blood–labyrinth
(BLaB),
blood–retinal
(BRB),
placental
(PB),
which
opens
exciting
possibilities
using
as
platform.
However,
systematic
reviews
summarizing
such
discoveries
still
limited.
review
covers
state-of-the-art
exosome
on
crossing
several
barriers
with
focus
current,
accepted
models
used
explain
mechanisms
crossing,
tight
junctions.
The
potential
design
engineer
enhance
efficacy,
leading
future
applications
precision
medicine
immunotherapy,
is
discussed.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Sept. 27, 2023
Abstract
Lymph
nodes
(LNs)
are
important
hubs
for
metastatic
cell
arrest
and
growth,
immune
modulation,
secondary
dissemination
to
distant
sites
through
a
series
of
mechanisms,
it
has
been
proved
that
lymph
node
metastasis
(LNM)
is
an
essential
prognostic
indicator
in
many
different
types
cancer.
Therefore,
oncologists
understand
the
mechanisms
tumor
cells
metastasize
LNs,
as
well
how
LNM
affects
prognosis
therapy
patients
with
cancer
order
provide
accurate
disease
assessment
effective
treatment
strategies.
In
recent
years,
updates
both
basic
clinical
studies
on
application
advanced
medical
technologies,
much
progress
made
understanding
strategies
diagnosis
LNM.
this
review,
current
knowledge
anatomical
physiological
characteristics
molecular
LNM,
described.
The
significance
summarized,
including
roles
playing
staging,
prediction,
selection
various
cancers.
And
novel
exploration
academic
disputes
recognition,
diagnosis,
therapeutic
interventions
LNs
also
discussed.
National Science Review,
Journal Year:
2024,
Volume and Issue:
11(4)
Published: Jan. 11, 2024
ABSTRACT
The
limited
infiltration
and
persistence
of
chimeric
antigen
receptor
(CAR)-T
cells
is
primarily
responsible
for
their
treatment
deficits
in
solid
tumors.
Here,
we
present
a
three-dimensional
scaffold,
inspired
by
the
physiological
process
T-cell
proliferation
lymph
nodes.
This
scaffold
gathers
function
loading,
delivery,
activation
expansion
CAR-T
to
enhance
therapeutic
effects
on
porous
device
made
from
poly(lactic-co-glycolic
acid)
microfluidic
technique
with
modification
stimulatory
signals,
including
anti-CD3,
anti-CD28
antibodies,
as
well
cytokines.
fosters
50-fold
cell
vitro
15-fold
vivo.
Particularly,
it
maintains
long-lasting
up
30
days
cervical
tumor
model
significantly
inhibits
growth.
biomimetic
delivery
strategy
provides
versatile
platform
treating
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(5), P. 1689 - 1714
Published: Jan. 2, 2025
In
recent
years,
nano-drug
delivery
systems
(Nano-DDS)
that
target
the
tumor
microenvironment
(TME)
to
overcome
multidrug
resistance
(MDR)
have
become
a
research
hotspot
in
field
of
cancer
therapy.
By
precisely
targeting
TME
and
regulating
its
unique
pathological
features,
such
as
hypoxia,
weakly
acidic
pH,
abnormally
expressed
proteins,
etc.,
these
Nano-DDS
enable
effective
therapeutic
agents
reversal
MDR.
This
scientific
community
is
increasing
investment
development
diversified
exploring
their
anti-drug
potential.
Therefore,
it
particularly
important
conduct
comprehensive
review
progress
TME-targeted
years.
After
brief
introduction
MDR,
design
principle
structure
liposomes,
polymer
micelles
inorganic
nanocarriers
are
focused
on,
characteristics
described.
It
also
demonstrates
how
break
through
MDR
treatment
various
mechanisms,
discusses
synthetic
innovation,
results
overcoming
mechanisms.
The
was
concluded
with
deliberations
on
key
challenges
future
outlooks
