Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Dendritic
cells
(DCs),
central
participants
in
the
allergic
immune
response,
can
capture
and
present
allergens
leading
to
inflammation
immunopathogenesis
of
rhinitis
(AR).
In
addition
initiating
antigen-specific
responses,
DCs
induce
tolerance
modulate
homeostasis.
As
a
special
type
DCs,
tolerogenic
(tolDCs)
achieve
mainly
by
suppressing
effector
T
cell
responses
inducing
regulatory
(Tregs).
TolDCs
suppress
modulating
tolerance,
thereby
reducing
symptoms
AR.
Activation
TLR4/IRAK4/NF-κB
signaling
pathway
contributes
release
inflammatory
cytokines,
inhibitors
this
production
tolDCs
alleviate
responses.
This
review
focuses
on
relationship
between
with
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2696 - 2696
Published: Jan. 31, 2023
Inflammatory
bowel
disease
(IBD)
is
an
umbrella
term
for
the
chronic
immune-mediated
idiopathic
inflammation
of
gastrointestinal
tract,
manifesting
as
Crohn's
(CD)
or
ulcerative
colitis
(UC).
IBD
characterized
by
exacerbated
innate
and
adaptive
immunity
in
gut
association
with
microbiota
dysbiosis
disruption
intestinal
barrier,
resulting
increased
bacterial
exposure.
In
response
to
signals
from
microorganisms
damaged
tissue,
immune
cells
produce
inflammatory
cytokines
factors
that
stimulate
T
B
system,
a
prominent
characteristic
patients
accumulation
T-cells
their
proinflammatory-associated
tissue.
Upon
antigen
recognition
activation,
CD4
differentiate
towards
range
distinct
phenotypes:
helper(h)1,
Th2,
Th9,
Th17,
Th22,
follicular
helper
(Tfh),
several
types
T-regulatory
(Treg).
are
generated
according
adapt
microenvironmental
conditions
participate
complex
network
interactions
among
other
modulate
further
progression
IBD.
This
review
examines
role
most
relevant
IBD,
highlighting
how
these
environment
interact
cell
populations
promote
inhibit
development
JAMA,
Journal Year:
2024,
Volume and Issue:
331(6), P. 510 - 510
Published: Feb. 13, 2024
Importance
An
estimated
7.6%
of
children
and
10.8%
adults
have
IgE-mediated
food-protein
allergies
in
the
US.
food
may
cause
anaphylaxis
death.
A
delayed,
allergic
response
to
food-carbohydrate
galactose-α-1,3-galactose
(alpha-gal)
mammalian
meat
affects
an
96
000
450
individuals
US
is
currently
a
leading
food-related
adults.
Observations
In
US,
9
foods
account
for
more
than
90%
allergies—crustacean
shellfish,
dairy,
peanut,
tree
nuts,
fin
fish,
egg,
wheat,
soy,
sesame.
Peanut
fatal
near-fatal
followed
by
nuts
shellfish.
The
fatality
rate
from
due
be
0.04
per
million
year.
Alpha-gal
syndrome,
which
associated
with
tick
bites,
rising
anaphylaxis.
seroprevalence
sensitization
alpha-gal
ranges
20%
31%
southeastern
Self-injectable
epinephrine
first-line
treatment
cornerstone
IgE-food
allergy
management
avoidance
culprit
allergen.
There
are
emerging
immunotherapies
desensitize
one
or
foods,
current
Food
Drug
Administration–approved
oral
immunotherapy
product
peanut
allergy.
Conclusions
Relevance
allergies,
including
delayed
responses
red
common
rarely,
requires
prompt
injection.
Both
syndrome
require
avoiding
allergenic
whereas
also
bites.
American Journal of Respiratory and Critical Care Medicine,
Journal Year:
2023,
Volume and Issue:
207(9), P. 1161 - 1170
Published: Jan. 26, 2023
Rationale:
Allergic
asthma
is
linked
to
impaired
bronchial
epithelial
secretion
of
IFNs,
which
may
be
causally
the
increased
risk
viral
exacerbations.
We
have
previously
shown
that
allergen
immunotherapy
(AIT)
effectively
reduces
exacerbations
and
prevents
respiratory
infections
requiring
antibiotics;
however,
whether
AIT
alters
antiviral
immunity
still
unknown.
Objectives:
To
investigate
effect
house
dust
mite
sublingual
(HDM-SLIT)
on
inflammatory
responses
in
patients
with
allergic
asthma.
Methods:
In
this
double-blind,
randomized
controlled
trial
(VITAL
[The
Effect
Allergen
Immunotherapy
Anti-viral
Immunity
Patients
Asthma]),
adult
HDM
received
HDM-SLIT
12-SQ
or
placebo
for
24
weeks.
Bronchoscopy
was
performed
at
baseline
Week
24,
included
sampling
human
cells.
Human
cells
were
cultured
stimulated
mimic
polyinosinic:polycytidylic
acid
(poly(I:C)).
mRNA
expression
quantified
using
qRT-PCR,
protein
concentrations
measured
multiplex
ELISA.
Measurements
Main
Results:
Thirty-nine
(n
=
20)
19).
resulted
acid-induced
IFN-β
both
gene
(P
0.009)
0.02)
levels.
IFN-λ
also
0.03),
whereas
IL-33
tended
decreased
0.09).
On
other
hand,
proinflammatory
cytokines
IL-6
TNF-α
(tumor
necrosis
factor-α)
0.08)
compared
group.
There
no
significant
changes
TSLP
(thymic
stromal
lymphopoietin),
IL-4,
IL-13,
IL-10.
Conclusions:
improves
resistance
infection.
These
results
potentially
explain
efficacy
reducing
Clinical
registered
www.clinicaltrials.gov
(NCT04100902).
Molecular Immunology,
Journal Year:
2023,
Volume and Issue:
158, P. 54 - 67
Published: April 27, 2023
House
dust
mite
(HDM)
allergy
belongs
to
the
most
important
allergies
and
affects
approximately
65–130
million
people
worldwide.
Additionally,
untreated
HDM
may
lead
development
of
severe
disease
manifestations
such
as
atopic
dermatitis
or
asthma.
Diagnosis
immunotherapy
allergic
patients
are
well
established
but
often
hampered
by
use
extracts
that
bad
quality
lack
allergens.
The
individual
allergens
seems
be
a
promising
alternative
natural
allergen
extracts,
since
they
represent
well-defined
components
can
easily
produced
quantified.
However,
thorough
characterization
is
required
determine
their
clinical
relevance
identify
those
for
correct
diagnosis
successful
immunotherapy.
This
review
gives
an
update
on
benefits
patients.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
24(4)
Published: March 19, 2024
Abstract
Layered
double
hydroxides
(LDH)
are
a
class
of
functional
anionic
clays
that
typically
consist
orthorhombic
arrays
metal
with
anions
sandwiched
between
the
layers.
Due
to
their
unique
properties,
including
high
chemical
stability,
good
biocompatibility,
controlled
drug
loading,
and
enhanced
bioavailability,
LDHs
have
many
potential
applications
in
medical
field.
Especially
fields
bioimaging
tumor
therapy.
This
paper
reviews
research
progress
nanocomposites
field
imaging
First,
structure
advantages
LDH
discussed.
Then,
several
commonly
used
methods
for
preparation
presented,
co‐precipitation,
hydrothermal
ion
exchange
methods.
Subsequently,
recent
advances
layered
cancer
therapy
highlighted.
Finally,
based
on
current
research,
we
summaries
prospects
challenges
diagnosis
Journal of Agriculture and Food Research,
Journal Year:
2024,
Volume and Issue:
16, P. 101189 - 101189
Published: May 6, 2024
Probiotics,
the
health-promoting
members
of
gut
microbiota,
have
been
shown
to
enhance
mucosal
and
systemic
immunity,
stimulate
cytokines,
chemokines,
antibodies,
regulate
T-cell
activity.
On
other
hand,
traditional
adjuvants
like
alum
limitations,
researchers
are
exploring
probiotics
as
a
new
generation
vaccine
treat
immune
disorders
effectiveness.
For
instance,
studies
show
that
probiotic
strains
Lactobacillus
rhamnosus
GG
(LGG)
can
improve
response
vaccines
against
rotavirus,
SARS-CoV-2,
influenza.
Besides,
delivered
through
various
routes
(oral
ocular)
could
offer
broader
protection
wider
range
infections.
not
only
boost
system
but
also
trigger
production
anti-inflammatory
cytokines
regulatory
cells,
they
potential
in
cancer
immunotherapy.
Studies
demonstrate
LGG
Bifidobacterium
longum
increase
efficacy
by
promoting
T
cell
infiltration,
thereby
inhibiting
tumor
growth.
Additionally,
suggest
specific
L.
SL42
casei
might
be
beneficial
for
cow's
milk
allergies.
In
line
with
this,
research
on
use
peanut
allergies
shows
promise.
However,
there
is
need
more
understand
mechanisms,
identify
optimal
strains,
determine
timing
duration
administration
clinical
outcomes.
This
review
aimed
shed
light
impact
immunomodulatory
immunogenic
agents
immunizations,
well
their
infectious
diseases,
allergies,
suppression.
