Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 156, P. 133 - 187

Published: Jan. 1, 2020

Language: Английский

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Bioprinting: From Tissue and Organ Development to in Vitro Models

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(19), P. 10547 - 10607

Published: May 14, 2020

Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments past years. Novel biomaterial inks used for formation bioinks developed, allowing manufacturing vitro models implants tested preclinically a certain degree success. Furthermore, incredible advances cell biology, namely, pluripotent stem cells, also contributed to latest milestones where more relevant tissues or organ-like constructs functionality can already be obtained. These strides possible multitude multidisciplinary teams around world, working make bioprinted organs functional. Yet, there is still long way go until these biofabricated will able reach clinics. In this review, we summarize main bioprinting activities linking them tissue organ development physiology. Most approaches focus on mimicking fully matured tissues. Future strategies might pursue earlier developmental stages organs. The continuous convergence experts fields material sciences, engineering, many other disciplines gradually allow us overcome barriers identified demanding path toward adoption replacements.

Language: Английский

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Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO ₃ nanoformulation triggers ferroptosis in target tumor cells

Science Advances, Journal Year: 2020, Volume and Issue: 6(18)

Published: April 29, 2020

This study describes a ferroptosis/apoptosis-based treatment strategy via the cooperation between Fe 2+ and doxorubicin.

Language: Английский

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Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow

Biomaterials, Journal Year: 2019, Volume and Issue: 206, P. 101 - 114

Published: March 16, 2019

Language: Английский

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Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Dec. 17, 2018

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment currently available in the clinics. Development of antioxidants with high accumulation rates kidneys highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters preferential uptake as novel nano-antioxidants for protection. These POM nanoclusters, readily variable valence state molybdenum ions, possess capability scavenge detrimental ROS. Our results demonstrate can efficiently alleviate clinical symptoms mice subjected AKI, verified by dynamic PET imaging 68Ga-EDTA, serum tests, tissue staining, and biomarkers detection kidneys. The protective effect against AKI living animals suggests exploring their use patients, well patients other ROS-related diseases.

Language: Английский

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Nanoparticle Toxicology

The Annual Review of Pharmacology and Toxicology, Journal Year: 2020, Volume and Issue: 61(1), P. 269 - 289

Published: Aug. 25, 2020

Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due this constant exposure, it critically important understand potential acute chronic adverse effects that may cause humans. In review, we explore highlight current state of nanotoxicology research with a focus on mechanistic understanding nanoparticle toxicity at organ, tissue, cell, biomolecular levels. We discuss nanotoxicity mechanisms, including generation reactive oxygen species, disintegration, modulation cell signaling pathways, protein corona formation, poly(ethylene glycol)-mediated immunogenicity. conclude perspective approaches advance toxicity. Such improved lead mitigation strategies could enable safe application Advances will ultimately inform efforts establish standardized regulatory frameworks goal fully exploiting nanotechnology while minimizing harm

Language: Английский

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Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 437, P. 129361 - 129361

Published: June 16, 2022

Language: Английский

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Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: March 4, 2021

Abstract Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management practical strategy can reduce risk of chemotherapy-related AKI, but at cost chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) prevent chemotherapy-induced AKI without interference agents. Specifically, in cortex, CNPs exhibit decomposes hydrogen peroxide, subsequently regulate ROS-involved genes activating Nrf2/Keap1 signaling pathway. These restore redox homeostasis for protection tubules. Under an acidic tumor microenvironment, become inert due excessive H + disrupts re-exposure active sites, allowing buildup chemotherapy-mediated generation kill cells. As ROS-modulating agents, incorporated context-dependent activity, hold great potential clinical prevention treatment patients.

Language: Английский

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Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

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A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(3), P. 1306 - 1312

Published: Sept. 17, 2020

Abstract The design of bright NIR‐II luminescent nanomaterials that enable efficient labelling proteins without disturbing their physiological properties in vivo is challenging. We developed an strategy to synthesize gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size Au NCs (<2 nm) and strong macrocycle‐based host–guest chemistry, as‐synthesized CD‐Au can readily label proteins/antibodies. Moreover, labelled proteins/antibodies highly tracking during blood circulation, biodistribution tumor targeting ability, thus leading a sensitive tumor‐targeted imaging. are stable harsh biological environment show good biocompatibility high renal clearance efficiency. Therefore, biolabels this study provide promising platform monitor behavior biomolecules living organisms.

Language: Английский

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