Emerging contaminants: A One Health perspective

The Innovation, Journal Year: 2024, Volume and Issue: 5(4), P. 100612 - 100612

Published: March 13, 2024

Language: Английский

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Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(1), P. 18 - 32

Published: July 10, 2023

Language: Английский

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Genomic surveillance for antimicrobial resistance — a One Health perspective

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(2), P. 142 - 157

Published: Sept. 25, 2023

Language: Английский

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Antimicrobial Resistance in the Global Health Network: Known Unknowns and Challenges for Efficient Responses in the 21st Century

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 1050 - 1050

Published: April 17, 2023

Antimicrobial resistance (AMR) is one of the Global Health challenges 21st century. The inclusion AMR on global map parallels scientific, technological, and organizational progress healthcare system socioeconomic changes last 100 years. Available knowledge about has mostly come from large institutions in high-income countries scattered studies across various fields, focused patient safety (infectious diseases), transmission pathways pathogen reservoirs (molecular epidemiology), extent problem at a population level (public health), their management cost (health economics), cultural issues (community psychology), events associated with historical periods (history science). However, there little dialogue between aspects that facilitate development, spread, evolution stakeholders (patients, clinicians, public health professionals, scientists, economic sectors, funding agencies). This study consists four complementary sections. first reviews factors have contributed to building current Healthcare system, scientific framework which traditionally been approached such novel approaching fourth globalization scenario. second discusses need reframe contexts. Given implementation policies guidelines are greatly influenced by information surveillance systems, third section, we review

Language: Английский

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Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 15, 2022

Infectious diseases caused by antibiotic-resistant bacterial (ARB) pathogens are a serious threat to human and animal health. The active surveillance of ARB using an integrated one-health approach can help reduce the emergence spread ARB, associated economic impact, guide antimicrobial stewardship programs. Wastewater (WWS) provides composite samples for total population, with easy access mixed community microbiome. This concept is emerging rapidly, but clinical utility, sensitivity, uniformity WWS remain poorly understood especially in relation evidence sewershed communities. Here, we systematically searched literature identify studies that have compared findings from antibiotic resistance genes (ARG) parallel, thereby evaluating how likely ARG relate cases Initially, 2,235 articles were obtained primary search keywords, 1,219 remained after de-duplication. Among these, 35 fulfilled criteria, additional 13 relevant included searching references literature. 48 papers, 34 used culture-based method, followed 11 metagenomics, three PCR-based methods. A 28 out conducted at single level, eight involved several countries, seven national or regional scales, five hospital levels. Our review revealed performance has been evaluated more frequently Escherichia coli, Enterococcus spp., other members family Enterobacteriaceae , not uniformly tested all pathogens. Many wastewater-based comparing evaluate public health risk ARB. Indeed, relating straightforward, as source wastewater cannot be only symptomatic individuals also asymptomatic carriers well sources. Further, varying fates each species within sewerage make aim connecting complicated. Therefore, future many AMR their one process simpler interpretation results easier.

Language: Английский

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MEGARes and AMR++, v3.0: an updated comprehensive database of antimicrobial resistance determinants and an improved software pipeline for classification using high-throughput sequencing

Nucleic Acids Research, Journal Year: 2022, Volume and Issue: 51(D1), P. D744 - D752

Published: Nov. 16, 2022

Antimicrobial resistance (AMR) is considered a critical threat to public health, and genomic/metagenomic investigations featuring high-throughput analysis of sequence data are increasingly common important. We previously introduced MEGARes, comprehensive AMR database with an acyclic hierarchical annotation structure that facilitates computational analysis, as well AMR++, customized bioinformatic pipeline specifically designed use MEGARes in for characterizing genes (ARGs) metagenomic data. Here, we present v3.0, published ARG sequences antimicrobial drugs, biocides, metals, AMR++ update our (available at MEGLab.org). Database annotations have been expanded include information regarding specific genomic locations single-nucleotide polymorphisms (SNPs) insertions and/or deletions (indels) when required by ARGs expression, the updated uses this check presence resistance-conferring genetic variants sequenced reads. This new encompasses 337 ARGs, whose could not be confirmed such manner. In 3.0, nodes ontology 4 compound types, 59 classes, 233 mechanisms 1448 gene groups classify 8733 accessions.

Language: Английский

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Antimicrobial Transformation Products in the Aquatic Environment: Global Occurrence, Ecotoxicological Risks, and Potential of Antibiotic Resistance

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(26), P. 9474 - 9494

Published: June 19, 2023

The global spread of antimicrobial resistance (AMR) is concerning for the health humans, animals, and environment in a One Health perspective. Assessments AMR associated environmental hazards mostly focus on parent compounds, while largely overlooking their transformation products (TPs). This review lists TPs identified surface water environments examines potential promotion, ecological risk, as well human using silico models. Our also summarizes key compartments TPs, related pathways reaching waters methodologies studying fate TPs. 56 covered by were prioritized via scoring ranking various risk hazard parameters. Most data occurrences to date have been reported Europe, little known about antibiotic Africa, Central South America, Asia, Oceania. Occurrence antiviral other antibacterial are even scarcer. We propose evaluation structural similarity between compounds TP assessment. predicted 13 especially tetracyclines macrolides. estimated ecotoxicological effect concentrations from experimental chemical bacteria, algae fleas, scaled potency differences quantitative structure–activity relationships (QSARs) baseline toxicity scaling factor similarity. Inclusion mixtures with increased quotient over threshold one 7 24 antimicrobials included this analysis, only had above one. Thirteen which 6 macrolide posed at least three tested species. There 12/21 that likely exhibit similar or higher level mutagenicity/carcinogenicity, respectively, than compound, tetracycline often showing mutagenicity. carcinogenicity belonged sulfonamides. be mobile but not bioaccumulative, 14 persistent. six highest-priority originated family antivirals. review, particular our concern, can support authorities planning intervention strategies source mitigation toward sustainable future.

Language: Английский

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A Review on Colistin Resistance: An Antibiotic of Last Resort

Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 772 - 772

Published: April 11, 2024

Antibiotic resistance has emerged as a significant global public health issue, driven by the rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously regarded last-resort antibiotic for treating infections caused Gram-negative bacteria, is increasingly becoming resistant due chromosomal mutations and acquisition genes carried plasmids, particularly mcr genes. The mobile colistin gene (mcr-1) was first discovered in E. coli from China 2016. Since that time, studies have reported different variants ranging mcr-1 mcr-10, mainly Enterobacteriaceae various parts world, which major concern health. co-presence colistin-resistant with other determinants further complicates treatment strategies underscores urgent need enhanced surveillance antimicrobial stewardship efforts. Therefore, understanding mechanisms driving monitoring its prevalence are essential steps addressing growing threat preserving efficacy existing This review critical role last-choice antibiotic, elucidates dissemination genes, explores evaluates current detection methods bacteria. objective shed light on these key aspects combating

Language: Английский

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An Overview of the Recent Advances in Antimicrobial Resistance

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920

Published: Sept. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Language: Английский

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Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1905 - 1925

Published: Jan. 1, 2024

A stimuli-responsive, injectable, and in situ -forming hydrogel with synergistic, self-healing, on-demand drug-delivery antibacterial properties.

Language: Английский

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