Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Feb. 23, 2021
Abstract
Upon
starvation,
cells
rewire
their
metabolism,
switching
from
glucose-based
metabolism
to
mitochondrial
oxidation
of
fatty
acids,
which
require
the
transfer
FAs
lipid
droplets
(LDs)
mitochondria
at
mitochondria−LD
membrane
contact
sites
(MCSs).
However,
factors
responsible
for
FA
these
MCSs
remain
uncharacterized.
Here,
we
demonstrate
that
vacuolar
protein
sorting-associated
13D
(VPS13D),
loss-of-function
mutations
cause
spastic
ataxia,
coordinates
trafficking
in
conjunction
with
endosomal
sorting
complex
required
transport
(ESCRT)
tumor
susceptibility
101
(TSG101).
The
VPS13
adaptor-binding
domain
VPS13D
and
TSG101
directly
remodels
LD
membranes
a
cooperative
manner.
human
binds
glycerophospholipids
vitro.
Depletion
VPS13D,
TSG101,
or
ESCRT-III
proteins
inhibits
LDs
mitochondria.
Our
findings
suggest
mediates
ESCRT-dependent
remodeling
facilitate
mitochondria-LD
contacts.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2021,
Volume and Issue:
17(1), P. 53 - 69
Published: July 10, 2021
Nanotechnologies
have
been
successfully
applied
to
the
treatment
of
various
diseases.
Plant-derived
exosome-like
nanoparticles
(PENs)
are
expected
become
effective
therapeutic
modalities
for
treating
disease
or
in
drug-delivery.
PENs
minimally
cytotoxic
healthy
tissues,
with
which
they
show
excellent
biocompatibility,
and
biased
towards
tumors
by
targeting
specific
tissues
through
special
endocytosis
mechanisms.
Thus,
use
these
may
expand
scope
drug
therapies
while
reducing
off-target
effects.
In
this
review,
we
summarize
fundamental
features
bioactivities
extracted
from
grape,
grapefruit,
ginger,
lemon,
broccoli
discuss
applications
particles
as
therapeutics
nanocarriers.
Microbiology and Immunology,
Journal Year:
2020,
Volume and Issue:
64(4), P. 252 - 269
Published: Jan. 8, 2020
Abstract
Inflammasomes
are
innate
immune
mechanisms
that
promote
inflammation
by
activating
the
protease
caspase‐1.
Active
caspase‐1
induces
pyroptosis,
a
necrotic
form
of
regulated
cell
death,
which
facilitates
release
intracellular
proinflammatory
molecules,
including
IL‐1
family
cytokines.
Recent
studies
identified
mediators
inflammasome‐associated
death
and
suggested
inflammasomes
induce
not
only
but
also
apoptosis.
Caspase‐1
has
potential
to
pyroptosis
apoptosis
in
manner
is
dependent
on
expression
mediator
gasdermin
D.
Caspase‐1‐induced
mediated
Bid
caspase‐7.
Caspase‐8
activated
following
formation
may
Because
contribute
pathogenesis
inflammatory
disorders
host
defenses
against
microbial
pathogens,
more
detailed
understanding
underlying
development
novel
therapeutic
strategies
for
inflammasome‐related
diseases.
Pyroptosis
been
implicated
diseases,
compounds
inhibit
this
process
have
reported.
The
molecular
its
physiological
implications
discussed
herein.
Cell,
Journal Year:
2020,
Volume and Issue:
182(5), P. 1140 - 1155.e18
Published: Aug. 18, 2020
The
endosomal
sorting
complex
required
for
transport-III
(ESCRT-III)
catalyzes
membrane
fission
from
within
necks,
a
process
that
is
essential
many
cellular
functions,
cell
division
to
lysosome
degradation
and
autophagy.
How
it
breaks
membranes,
though,
remains
unknown.
Here,
we
characterize
sequential
polymerization
of
ESCRT-III
subunits
that,
driven
by
recruitment
cascade
continuous
subunit-turnover
powered
the
ATPase
Vps4,
induces
deformation
fission.
During
this
process,
exchange
Vps24
Did2
tilt
in
polymer-membrane
interface,
which
triggers
transition
flat
spiral
polymers
helical
filament
drive
formation
protrusions,
ends
with
highly
constricted
Did2-Ist1
co-polymer
show
competent
promote
when
bound
on
inside
necks.
Overall,
our
results
suggest
mechanism
stepwise
changes
structure
mechanical
properties
via
catalyze
activity.
Molecular Cancer,
Journal Year:
2022,
Volume and Issue:
21(1)
Published: Sept. 13, 2022
Abstract
Mesenchymal
stem
cells
(MSCs)
are
multipotent
stromal
that
can
be
obtained
from
various
human
tissues
and
organs.
They
differentiate
into
a
wide
range
of
cell
types,
including
osteoblasts,
adipocytes
chondrocytes,
thus
exhibiting
great
potential
in
regenerative
medicine.
Numerous
studies
have
indicated
MSCs
play
critical
roles
cancer
biology.
The
crosstalk
between
tumour
has
been
found
to
regulate
many
behaviours,
such
as
proliferation,
metastasis
epithelial-mesenchymal
transition
(EMT).
Multiple
lines
evidence
demonstrated
secrete
exosomes
modulate
the
microenvironment
important
development.
Notably,
very
recent
works
shown
mesenchymal
cell-derived
(MSC-derived
exosomes)
critically
involved
resistance
chemotherapy
agents,
targeted-therapy
drugs,
radiotherapy
immunotherapy.
In
this
review,
we
systematically
summarized
emerging
detailed
molecular
mechanisms
MSC-derived
mediating
therapy
resistance,
providing
novel
insights
clinical
applications
management.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(7), P. 3976 - 4050
Published: March 29, 2023
DNA
nanotechnology
is
a
unique
field,
where
physics,
chemistry,
biology,
mathematics,
engineering,
and
materials
science
can
elegantly
converge.
Since
the
original
proposal
of
Nadrian
Seeman,
significant
advances
have
been
achieved
in
past
four
decades.
During
this
glory
time,
origami
technique
developed
by
Paul
Rothemund
further
pushed
field
forward
with
vigorous
momentum,
fostering
plethora
concepts,
models,
methodologies,
applications
that
were
not
thought
before.
This
review
focuses
on
recent
progress
origami-engineered
nanomaterials
five
years,
outlining
exciting
achievements
as
well
unexplored
research
avenues.
We
believe
spirit
assets
Seeman
left
for
scientists
will
continue
to
bring
interdisciplinary
innovations
useful
next
decade.
Cells,
Journal Year:
2023,
Volume and Issue:
12(10), P. 1416 - 1416
Published: May 17, 2023
Extracellular
vesicles
(EVs)
such
as
ectosomes
and
exosomes
have
gained
attention
promising
natural
carriers
for
drug
delivery.
Exosomes,
which
range
from
30
to
100
nm
in
diameter,
possess
a
lipid
bilayer
are
secreted
by
various
cells.
Due
their
high
biocompatibility,
stability,
low
immunogenicity,
favored
cargo
carriers.
The
membrane
of
also
offers
protection
against
degradation,
making
them
desirable
candidate
However,
loading
into
remains
be
challenge.
Despite
strategies
incubation,
electroporation,
sonication,
extrusion,
freeze–thaw
cycling,
transfection
that
been
developed
facilitate
loading,
inadequate
efficiency
still
persists.
This
review
an
overview
current
delivery
using
summarizes
recent
approaches
small-molecule,
nucleic
acid,
protein
drugs
exosomes.
With
insights
these
studies,
we
provide
ideas
more
efficient
effective
molecules
