Science,
Journal Year:
2022,
Volume and Issue:
376(6598), P. 1192 - 1202
Published: May 5, 2022
Caloric
restriction
(CR)
prolongs
life
span,
yet
the
mechanisms
by
which
it
does
so
remain
poorly
understood.
Under
CR,
mice
self-impose
chronic
cycles
of
2-hour
feeding
and
22-hour
fasting,
raising
question
if
is
calories,
or
time
day
that
cause
this
increased
span.
We
show
here
30%
CR
was
sufficient
to
extend
span
10%;
however,
a
daily
fasting
interval
circadian
alignment
acted
together
35%
in
male
C57BL/6J
mice.
These
effects
were
independent
body
weight.
Aging
induced
widespread
increases
gene
expression
associated
with
inflammation
decreases
genes
encoding
components
metabolic
pathways
liver
from
ad
libitum-fed
at
night
ameliorated
these
aging-related
changes.
Our
results
interventions
promote
longevity
provide
perspective
further
explore
aging.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 23, 2022
Nutriments
have
been
deemed
to
impact
all
physiopathologic
processes.
Recent
evidences
in
molecular
medicine
and
clinical
trials
demonstrated
that
adequate
nutrition
treatments
are
the
golden
criterion
for
extending
healthspan
delaying
ageing
various
species
such
as
yeast,
drosophila,
rodent,
primate
human.
It
emerges
develop
precision-nutrition
therapeutics
slow
age-related
biological
processes
treat
diverse
diseases.
However,
nutritive
advantages
frequently
diversify
among
individuals
well
organs
tissues,
which
brings
challenges
this
field.
In
review,
we
summarize
different
forms
of
dietary
interventions
extensively
prescribed
improvement
disease
treatment
pre-clinical
or
clinical.
We
discuss
nutrient-mediated
mechanisms
including
metabolic
regulators,
metabolism
pathways,
epigenetic
circadian
clocks.
Comparably,
describe
diet-responsive
effectors
by
influence
endocrinic,
immunological,
microbial
neural
states
responsible
improving
health
preventing
multiple
diseases
humans.
Furthermore,
expatiate
patterns
dietotheroapies,
fasting,
calorie-restricted
diet,
ketogenic
high-fibre
plants-based
protein
restriction
diet
with
specific
reduction
amino
acids
microelements,
potentially
affecting
morbid
states.
Altogether,
emphasize
profound
nutritional
therapy,
highlight
crosstalk
explored
critical
factors
individualized
therapeutic
approaches
predictors.
Cancer and Metastasis Reviews,
Journal Year:
2022,
Volume and Issue:
41(3), P. 607 - 625
Published: June 25, 2022
Abstract
Obesity,
exceptionally
prevalent
in
the
USA,
promotes
incidence
and
progression
of
numerous
cancer
types
including
breast
cancer.
Complex,
interacting
metabolic
immune
dysregulation
marks
development
both
obesity.
Obesity
chronic
low-grade
inflammation,
particularly
white
adipose
tissue,
which
drives
dysfunction
marked
by
increased
pro-inflammatory
cytokine
production,
alternative
macrophage
activation,
reduced
T
cell
function.
Breast
tissue
is
predominantly
composed
adipose,
developing
readily
directly
interacts
with
cells
signals
from
remodeled
This
review
discusses
biological
mechanisms
through
obesity
cancer,
role
health
disparities,
dietary
interventions
to
mitigate
adverse
effects
on
We
detail
intersection
an
emphasis
shared
unique
patterns
these
disease
processes.
have
highlighted
key
areas
biology
exacerbated
obesity,
incidence,
progression,
therapeutic
response.
posit
that
interception
obesity-driven
will
require
limit
protumor
signaling
obese
consider
genetic,
structural,
social
determinants
obesity–breast
link.
Finally,
we
evidence
for
various
offset
clinical
preclinical
studies
In
light
strong
associations
between
rising
rates
many
parts
world,
effective,
safe,
well-tolerated,
equitable
burden
are
urgently
needed.
Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(1), P. 150 - 165.e4
Published: Jan. 1, 2023
Time-restricted
feeding
(TRF)
is
an
emerging
behavioral
nutrition
intervention
that
involves
a
daily
cycle
of
and
fasting.
In
both
animals
humans,
TRF
has
pleiotropic
health
benefits
arise
from
multiple
organ
systems,
yet
the
molecular
basis
TRF-mediated
not
well
understood.
Here,
we
subjected
mice
to
isocaloric
ad
libitum
(ALF)
or
western
diet
examined
gene
expression
changes
in
samples
taken
22
organs
brain
regions
collected
every
2
h
over
24-h
period.
We
discovered
profoundly
impacts
expression.
Nearly
80%
all
genes
show
differential
rhythmicity
under
at
least
one
tissue.
Functional
annotation
these
revealed
tissue-
pathway-specific
TRF.
These
findings
resources
provide
critical
foundation
for
future
mechanistic
studies
will
help
guide
human
time-restricted
eating
(TRE)
interventions
treat
various
disease
conditions
with
without
pharmacotherapies.
Progress in Lipid Research,
Journal Year:
2023,
Volume and Issue:
91, P. 101235 - 101235
Published: May 15, 2023
Lipids
play
important
roles
in
energy
metabolism
along
with
diverse
aspects
of
biological
membrane
structure,
signaling
and
other
functions.
Perturbations
lipid
are
responsible
for
the
development
various
pathologies
comprising
metabolic
syndrome,
obesity,
type
2
diabetes.
Accumulating
evidence
suggests
that
circadian
oscillators,
operative
most
cells
our
body,
coordinate
temporal
homeostasis.
In
this
review
we
summarize
current
knowledge
on
regulation
digestion,
absorption,
transportation,
biosynthesis,
catabolism,
storage.
Specifically,
focus
molecular
interactions
between
functional
clockwork
biosynthetic
pathways
major
classes
cholesterol,
fatty
acids,
triacylglycerols,
glycerophospholipids,
glycosphingolipids,
sphingomyelins.
A
growing
body
epidemiological
studies
associate
a
socially
imposed
misalignment
common
modern
society
incidence
disorders,
however
disruption
rhythms
connection
has
only
been
recently
revealed.
Here,
highlight
recent
unravel
mechanistic
link
intracellular
clocks,
homeostasis
diseases
based
animal
models
clock
innovative
translational
humans.
We
also
discuss
perspectives
manipulating
oscillators
as
potentially
powerful
approach
preventing
managing
disorders
human
patients.
