Developmental Dynamics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Abstract
Background
Skeletal
muscle
stem
cells
(MuSCs)
played
an
important
role
in
maintaining
the
proper
function
of
tissues.
In
adults,
they
normally
remained
a
quiescent
state
and
activated
upon
stimulation
to
undergo
self‐renewal
or
myogenic
differentiation.
This
process
was
complexly
regulated
by
cytokines,
molecular
mechanisms
that
promoted
MuSCs
activation
largely
unknown.
Results
Here,
we
analyzed
transcriptome
data
from
different
stimuli
using
weighted
gene
co‐expression
network
analysis
(WGCNA)
identified
key
long
non‐coding
RNA
SNHG1
(lncSNHG1),
which
promotes
transition
MuSCs.
Overexpression
lncSNHG1
able
promote
proliferation
differentiation
MuSCs,
whereas
knockdown
resulted
opposite
results.
Mechanistically,
disruption
Wnt/β‐catenin
pathway
blocked
quiescence
exit
induced
lncSNHG1.
Conclusions
We
conclude
is
factor
cell
through
pathway.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 2, 2024
Abstract
Alternative
splicing
(AS)
serves
as
a
pivotal
mechanism
in
transcriptional
regulation,
engendering
transcript
diversity,
and
modifications
protein
structure
functionality.
Across
varying
tissues,
developmental
stages,
or
under
specific
conditions,
AS
gives
rise
to
distinct
splice
isoforms.
This
implies
that
these
isoforms
possess
unique
temporal
spatial
roles,
thereby
associating
with
standard
biological
activities
diseases.
Among
these,
AS-related
RNA-binding
proteins
(RBPs)
play
an
instrumental
role
regulating
alternative
events.
Under
physiological
the
diversity
of
mediated
by
influences
structure,
function,
interaction,
localization
proteins,
participating
differentiation
development
array
tissues
organs.
pathological
alterations
are
linked
various
diseases,
particularly
cancer.
These
changes
can
lead
gene
patterns,
culminating
loss
For
instance,
cancer,
abnormalities
RBPs
may
result
aberrant
expression
cancer-associated
genes,
promoting
onset
progression
tumors.
also
associated
numerous
neurodegenerative
diseases
autoimmune
Consequently,
study
across
different
holds
significant
value.
review
provides
detailed
account
recent
advancements
tissue
which
aids
deepening
understanding
complexity
offers
new
insights
methodologies
for
precision
medicine.
Cell stem cell,
Journal Year:
2024,
Volume and Issue:
31(1), P. 7 - 24
Published: Jan. 1, 2024
All
adult
tissues
experience
wear
and
tear.
Most
can
compensate
for
cell
loss
through
the
activity
of
resident
stem
cells.
Although
cellular
maintenance
strategies
vary
greatly
between
different
(read:
postnatal)
tissues,
function
cells
is
best
defined
by
their
capacity
to
replace
lost
tissue
division.
We
discuss
a
set
six
complementary
hallmarks
that
are
key
enabling
features
this
basic
function.
These
include
longevity
self-renewal,
multipotency,
transplantability,
plasticity,
dependence
on
niche
signals,
genome
integrity.
these
in
context
some
best-understood
niches.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Redox
signaling
acts
as
a
critical
mediator
in
the
dynamic
interactions
between
organisms
and
their
external
environment,
profoundly
influencing
both
onset
progression
of
various
diseases.
Under
physiological
conditions,
oxidative
free
radicals
generated
by
mitochondrial
respiratory
chain,
endoplasmic
reticulum,
NADPH
oxidases
can
be
effectively
neutralized
NRF2-mediated
antioxidant
responses.
These
responses
elevate
synthesis
superoxide
dismutase
(SOD),
catalase,
well
key
molecules
like
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
glutathione
(GSH),
thereby
maintaining
cellular
redox
homeostasis.
Disruption
this
finely
tuned
equilibrium
is
closely
linked
to
pathogenesis
wide
range
Recent
advances
have
broadened
our
understanding
molecular
mechanisms
underpinning
dysregulation,
highlighting
pivotal
roles
genomic
instability,
epigenetic
modifications,
protein
degradation,
metabolic
reprogramming.
findings
provide
foundation
for
exploring
regulation
mechanistic
basis
improving
therapeutic
strategies.
While
antioxidant-based
therapies
shown
early
promise
conditions
where
stress
plays
primary
pathological
role,
efficacy
diseases
characterized
complex,
multifactorial
etiologies
remains
controversial.
A
deeper,
context-specific
signaling,
particularly
redox-sensitive
proteins,
designing
targeted
aimed
at
re-establishing
balance.
Emerging
small
molecule
inhibitors
that
target
specific
cysteine
residues
proteins
demonstrated
promising
preclinical
outcomes,
setting
stage
forthcoming
clinical
trials.
In
review,
we
summarize
current
intricate
relationship
disease
also
discuss
how
these
insights
leveraged
optimize
strategies
practice.
Medicine Plus,
Journal Year:
2024,
Volume and Issue:
1(1), P. 100003 - 100003
Published: Jan. 12, 2024
Homeostasis
is
essential
for
the
maintenance
of
health,
and
how
it
maintained
focus
attention
in
homeostatic
medicine.
As
a
natural
dietary
nutrient,
nitrate
critical
regulating
homeostasis.
This
article
summarizes
nitrate's
cognitive
history,
sources,
metabolism.
It
discusses
relationship
possible
mechanism
between
organism
homeostasis
from
three
aspects:
flora
homeostasis,
inflammation-immunity
energy
metabolism
as
well
clinical
application
scenarios
promising
new
generation
drugs,
including
preventing
treating
multi-system
diseases,
reducing
injury,
improving
exercise
ability,
glucose
lipid
metabolism,
assisting
tumor
treatment.
An
increased
understanding
impact
on
body
could
foster
research
concept
its
disease
prevention
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: Jan. 30, 2024
Abstract
Skeletal
muscle
is
a
highly
specialized
tissue
composed
of
myofibres
that
performs
crucial
functions
in
movement
and
metabolism.
In
response
to
external
stimuli
injuries,
range
stem/progenitor
cells,
with
stem
cells
or
satellite
(MuSCs)
being
the
predominant
cell
type,
are
rapidly
activated
repair
regenerate
skeletal
within
weeks.
Under
normal
conditions,
MuSCs
remain
quiescent
state,
but
become
proliferative
differentiate
into
new
injury.
addition
MuSCs,
some
interstitial
progenitor
(IPCs)
such
as
fibro-adipogenic
progenitors
(FAPs),
pericytes,
expressing
PW1
negative
for
Pax7
(PICs),
side
population
(SPCs),
CD133-positive
Twist2-positive
have
been
identified
playing
direct
indirect
roles
regenerating
tissue.
Here,
we
highlight
heterogeneity,
molecular
markers,
functional
properties
these
explore
role
homeostasis,
aging,
muscle-related
diseases.
This
review
provides
critical
insights
future
therapies
aimed
at
treating
Cell Regeneration,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: March 11, 2024
Abstract
Stem
cells
are
pivotal
players
in
the
intricate
dance
of
embryonic
development,
tissue
maintenance,
and
regeneration.
Their
behavior
is
delicately
balanced
between
maintaining
their
pluripotency
differentiating
as
needed.
Disruptions
this
balance
can
lead
to
a
spectrum
diseases,
underscoring
importance
unraveling
complex
molecular
mechanisms
that
govern
stem
cell
fate.
Forkhead
box
O
(FOXO)
proteins,
family
transcription
factors,
at
heart
regulation,
influencing
myriad
cellular
processes
such
survival,
metabolism,
DNA
repair.
multifaceted
role
steering
destiny
evident,
they
wield
influence
over
self-renewal,
quiescence,
lineage-specific
differentiation
both
adult
cells.
This
review
delves
into
structural
regulatory
intricacies
FOXO
shedding
light
on
roles
shaping
fate
By
providing
insights
specific
functions
determining
fate,
aims
pave
way
for
targeted
interventions
could
modulate
potentially
revolutionize
treatment
prevention
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 12, 2024
Abstract
The
current
first-line
treatment
for
repairing
cartilage
defects
in
clinical
practice
is
the
creation
of
microfractures
(MF)
to
stimulate
release
mesenchymal
stem
cells
(MSCs);
however,
this
method
has
many
limitations.
Recent
studies
have
found
that
MSC-derived
extracellular
vesicles
(MSC-EVs)
play
an
important
role
tissue
regeneration.
This
study
aimed
verify
whether
MSC-EVs
promote
damage
repair
mediated
by
MFs
and
explore
mechanisms.
In
vitro
experiments
showed
human
umbilical
cord
Wharton’s
jelly
(hWJMSC-EVs)
promoted
vitality
chondrocytes
proliferation
differentiation
ability
bone
marrow-derived
MSCs.
was
mainly
because
hWJMSC-EVs
carry
integrin
beta-1
(ITGB1),
MSCs
overexpress
ITGB1
after
absorbing
EVs,
thereby
activating
transforming
growth
factor-β/Smad2/3
axis.
a
rabbit
knee
joint
model
osteochondral
defect
repair,
injection
different
concentrations
into
cavity
concentration
50
µg/ml
significantly
improved
formation
transparent
MF
surgery.
Extraction
regenerated
revealed
changes
ITGB1,
factor-β,
Smad2/3
were
directly
proportional
cartilage.
summary,
Graphical
abstract
