Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 312, P. 17 - 21
Published: June 9, 2022
Language: Английский
International Journal of Molecular Medicine, Journal Year: 2021, Volume and Issue: 48(2)
Published: June 11, 2021
Kidney stone disease is one of the oldest diseases known to medicine; however, mechanisms formation and development remain largely unclear. Over past decades, a variety theories strategies have been developed utilized in surgical management kidney stones, as result recent technological advances. Observations from authors other research groups suggest that there are five entirely different main for formation. Urinary supersaturation crystallization driving force intrarenal crystal precipitation. Randall's plaques recognized origin calcium oxalate Sex hormones may be key players nephrolithiasis thus potential targets new drugs suppress The microbiome, including urease‑producing bacteria, nanobacteria intestinal microbiota, likely profound effect on urological health, both positive negative, owing its metabolic output contributions. Lastly, immune response, particularly macrophage differentiation, play crucial roles renal In present study, current knowledge each these aspects reviewed. This used explore novel opportunities improve understanding initiation stones urologists, nephrologists primary care.
Language: Английский
Citations
178
Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(3), P. 555 - 569
Published: March 9, 2023
Kidney stone disease (KSD) (alternatively nephrolithiasis or urolithiasis) is a global health care problem that affects people in almost all of developed and developing countries. Its prevalence has been continuously increasing with high recurrence rate after removal. Although effective therapeutic modalities are available, preventive strategies for both new recurrent stones required to reduce physical financial burdens KSD. To prevent kidney formation, its etiology risk factors should be first considered. Low urine output dehydration the common risks types, whereas hypercalciuria, hyperoxaluria, hypocitraturia major calcium stones. In this article, up-to-date knowledge on (nutrition-based mainly) KSD provided. Important roles fluid intake (2.5–3.0 L/d), diuresis (>2.0–2.5 lifestyle habit modifications (for example, maintain normal body mass index, compensation working high-temperature environment, avoid cigarette smoking), dietary management [for sufficient at 1000–1200 mg/d, limit sodium 2 3–5 g/d chloride (NaCl), oxalate-rich foods, vitamin C D supplements, animal proteins 0.8–1.0 g/kg weight/d but increase plant patients uric acid those hyperuricosuria, proportion citrus fruits, consider lime powder supplementation] summarized. Moreover, uses natural bioactive products caffeine, epigallocatechin gallate, diosmin), medications thiazides, alkaline citrate, other alkalinizing agents, allopurinol), bacterial eradication, probiotics also discussed.
Language: Английский
Citations
149
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 21, 2023
Background The incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. systemic immune-inflammatory index (SII) was initially identified as a prognosis multiple diseases. We performed an updated analysis on impact SII stones. Methods This compensatory cross-sectional study enrolled participants from National Health Nutrition Examination Survey 2007-2018. Univariate multivariate logistic regression analyses were to investigate association between Results Of 22220 participants, mean (SD) age 49.45 ± 17.36 years old, with 9.87% A fully adjusted model showed that higher than 330 x 10 9 /L parallel associated (Odds ratio [OR] = 1.282, 95% Confidence interval [CI] 1.023 1.608, P 0.034) in adults aged 20-50. However, no difference found elderly subgroup. Multiple imputation confirmed robustness our results. Conclusions Our findings suggested positively high risk US less 50. outcome compensated for previous studies still needed more large-scale prospective cohorts validation.
Language: Английский
Citations
64
American Journal of Kidney Diseases, Journal Year: 2023, Volume and Issue: 82(5), P. 617 - 634
Published: Aug. 9, 2023
Language: Английский
Citations
58
Small, Journal Year: 2023, Volume and Issue: 19(23)
Published: March 3, 2023
Abstract Nature provides a successful evolutionary direction for single‐celled organisms to solve complex problems and complete survival tasks – pseudopodium. Amoeba, unicellular protozoan, can produce temporary pseudopods in any by controlling the directional flow of protoplasm perform important life activities such as environmental sensing, motility, predation, excretion. However, creating robotic systems with pseudopodia emulate adaptability tasking capabilities natural amoeba or amoeboid cells remains challenging. Here, this work presents strategy that uses alternating magnetic fields reconfigure droplet into Amoeba‐like microrobot, mechanisms generation locomotion are analyzed. By simply adjusting field direction, microrobots switch monopodia, bipodia, modes, performing all pseudopod operations active contraction, extension, bending, movement. The endow robots excellent maneuverability adapt variations, including spanning 3D terrains swimming bulk liquids. Inspired “Venom,” phagocytosis parasitic behaviors have also been investigated. Parasitic droplets inherit robot, expanding their applicable scenarios reagent analysis, microchemical reactions, calculi removal, drug‐mediated thrombolysis. This microrobot may provide fundamental understanding livings, potential applications biotechnology biomedicine.
Language: Английский
Citations
51
International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: May 20, 2024
Kidney stones are among the most common urological conditions affecting ~9% of world population. Although some unhealthy diets and lifestyles reportedly risk factors for kidney stone, association between daily sitting time stone has not been explored.
Language: Английский
Citations
27
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3075 - 3075
Published: March 6, 2024
Kidney stone disease (KSD) is one of the most common urological diseases. The incidence kidney stones has increased dramatically in last few decades. are mineral deposits calyces or pelvis, free attached to renal papillae. They contain crystals and organic components, they made when urine supersaturated with minerals. Calcium-containing common, calcium oxalate as main component stones. However, many these form on a phosphate matrix called Randall’s plaque, which found surface papilla. etiology multifactorial, recurrence rate high 50% within 5 years after first onset. There great need for prevention that requires better understanding mechanisms involved formation facilitate development more effective drugs. This review aims understand pathophysiology molecular known date prevent recurrences, behavioral nutritional interventions, well pharmacological treatments specific type stone.
Language: Английский
Citations
26
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: April 22, 2024
Abstract Sepsis, a severe systemic inflammatory response to infection, remains leading cause of morbidity and mortality worldwide. Exosomes, as mediators intercellular communication, play pivotal role in the pathogenesis sepsis through modulating immune responses, metabolic reprogramming, coagulopathy, organ dysfunction. This review highlights emerging significance exosomes these processes. Initially, it provides an in-depth insight into exosome biogenesis characterization, laying groundwork for understanding their diverse intricate functions. Subsequently, explores regulatory roles various cells such neutrophils, macrophages, dendritic cells, T B cells. analysis elucidates how are thus contributing complexity pathophysiology. Additionally, this delves regulation metabolism subsequent dysfunction sepsis. It also establishes connection between coagulation cascade, which affects endothelial integrity promotes thrombogenesis Moreover, discusses dual progression resolution sepsis, exploring complex involvement inflammation healing Furthermore, underscores potential biomarkers therapeutic targets. Understanding mechanisms presents new opportunities novel interventions mitigate outcomes emphasizing promise research critical care settings.
Language: Английский
Citations
19
Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 19(2), P. 123 - 138
Published: Nov. 3, 2022
Language: Английский
Citations
65
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Jan. 27, 2022
Calcium oxalate nephrolithiasis is a common and highly recurrent disease in urology; however, its precise pathogenesis still unknown. Recent research has shown that renal inflammatory injury as result of the cell-crystal reaction plays crucial role development calcium kidney stones. An increasing amount have confirmed inflammation mediated by can lead to cells, promote intracellular expression NADPH oxidase, induce extensive production reactive oxygen species, activate NLRP3 inflammasome, discharge great number factors, trigger cascading reactions, aggregation, nucleation growth process salt crystals, ultimately intrarenal crystals even The tubular epithelial cells (RTECs)-crystal reaction, macrophage-crystal calcifying nanoparticles, endoplasmic reticulum stress, autophagy activation, other regulatory factors mechanisms are involved this process.
Language: Английский
Citations
53