Hippocampal output suppresses orbitofrontal cortex schema cell formation DOI Creative Commons
Wenhui Zong, Jingfeng Zhou, Matthew P.H. Gardner

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Both the orbitofrontal cortex (OFC) and hippocampus (HC) are implicated in formation of cognitive maps their generalization into schemas. However, how these areas interact supporting this function remains unclear, with some proposals a serial model which OFC draws on task representations created by HC to extract key behavioral features others suggesting parallel both regions construct that highlight different types information. In present study, we tested between two models asking schema correlates rat would be affected inactivating output HC, after learning during transfer across problems. We found prevalence content were unaffected one major area, ventral subiculum, learning, whereas inactivation accelerated formation. These results favor proposal operate defining

Language: Английский

Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective DOI Creative Commons
Ileana L. Hanganu‐Opatz, Thomas Klausberger, Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

Citations

52
Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment DOI
Bei Zhang, Edmund T. Rolls, Xiang Wang

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(4), P. 914 - 928

Published: Jan. 12, 2024

Language: Английский

Citations

48
Context-dependent decision-making in the primate hippocampal–prefrontal circuit DOI Creative Commons
Thomas W. Elston, Joni D. Wallis

Nature Neuroscience, Journal Year: 2025, Volume and Issue: 28(2), P. 374 - 382

Published: Jan. 6, 2025

Language: Английский

Citations

4
Schemas, reinforcement learning and the medial prefrontal cortex DOI
Oded Bein, Yael Niv

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

4
Basis functions for complex social decisions in dorsomedial frontal cortex DOI Creative Commons
Marco K. Wittmann, Yongling Lin, Deng Pan

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Navigating social environments is a fundamental challenge for the brain. It has been established that brain solves this problem, in part, by representing information an agent-centric manner; knowledge about others’ abilities or attitudes tagged to individuals such as ‘oneself’ ‘other’ 1–6 . This intuitive approach informed understanding of key nodes parts brain, dorsomedial prefrontal cortex (dmPFC) and anterior cingulate (ACC) 7–9 However, patterns combinations which might interact with one another important identities individuals. Here, four studies using functional magnetic resonance imaging, behavioural experiments group decision-making task, we show dmPFC ACC represent combinatorial possibilities interaction afforded given situation, they do so compressed format resembling basis functions used spatial, visual motor domains 10–12 The align types, opposed individual identities. Our results indicate there are deep analogies between abstract neural coding schemes domain construction our sense identity.

Language: Английский

Citations

3
Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2022, Volume and Issue: 33(5), P. 533 - 572

Published: Sept. 7, 2022

Abstract Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the location being looked at. The representation is allocentric, that responses are locations “out there” world, relatively invariant with respect retinal position, eye head direction, place where individual located. underlying connectivity humans from ventromedial visual cortical regions scene area, leading theory cells formed by combinations of overlapping feature inputs self‐organized based on their closeness space. Thus, although represent “where” for episodic memory navigation, they ventral stream what area. A second driver parietal inputs, which it proposed provide idiothetic update cells, used recall navigation when details obscured. Inferior temporal object “what” orbitofrontal cortex reward connect human hippocampal system, macaques can be associated hippocampus cell representations implement memory. also a basis series viewed landmarks, providing goals then implemented involved visuomotor actions presence foveate vision highly developed lobe processing including key understanding primate hippocampus, roles this system navigation.

Language: Английский

Citations

60
Amygdala-cortical collaboration in reward learning and decision making DOI Creative Commons
Kate M. Wassum

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Sept. 5, 2022

Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome each option and its current desirability. These mental simulations are informed by stored memories associative relationships that exist within an environment. In this review, I discuss recent investigations function circuitry between basolateral amygdala (BLA) lateral (lOFC) medial (mOFC) orbitofrontal cortex in learning use reward memories. draw conclusions from data collected using sophisticated behavioral approaches to diagnose content appetitive memory combination with modern circuit dissection tools. propose that, via their direct bidirectional connections, BLA OFC collaborate help us encode detailed, outcome-specific, state-dependent those enable predictions inferences support adaptive making. Whereas lOFC→BLA projections mediate encoding outcome-specific memories, mOFC→BLA regulate ability these inform pursuit decisions. lOFC mOFC both contribute guide The BLA→lOFC pathway mediates represent identity a predicted BLA→mOFC facilitates understanding value events. Thus, outline neuronal architecture for provide new testable hypotheses as well implications maladaptive

Language: Английский

Citations

40
Within‐subject reliability of brain networks during advanced meditation: An intensively sampled 7 Tesla MRI case study DOI Creative Commons
Saampras Ganesan, Winson Fu Zun Yang, Avijit Chowdhury

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(7)

Published: May 1, 2024

Abstract Advanced meditation such as jhana can produce various altered states of consciousness (jhanas) and cultivate rewarding psychological qualities including joy, peace, compassion, attentional stability. Mapping the neurobiological substrates inform development application advanced to enhance well‐being. Only two prior studies have attempted investigate neural correlates meditation, rarity adept practitioners has largely restricted size extent these studies. Therefore, examining consistency reliability observed brain responses associated with be valuable. In this study, we aimed characterize functional magnetic resonance imaging (fMRI) within a single subject over repeated runs in canonical networks during performed by an practitioner 5 days (27 fMRI runs) inside ultra‐high field 7 Tesla MRI scanner. We found that thalamus several cortical networks, is, somatomotor, limbic, default‐mode, control, temporo‐parietal, demonstrated good within‐subject across all jhanas. Additionally, other relevant (e.g., attention, salience) showed noticeable increases when measurements were adjusted for variability self‐reported phenomenology related meditation. Overall, present preliminary template reliable areas likely underpinning core neurocognitive elements highlight utility neurophenomenological experimental designs better characterizing neuronal meditative states.

Language: Английский

Citations

9
Transcranial direct current stimulation for patients with walking difficulties caused by cerebral small vessel disease: a randomized controlled study DOI Creative Commons
Qiaoqiao Xu,

Wenwen Yin,

Xia Zhou

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 7, 2025

Cerebral small vessel disease (CSVD) is a chronic systemic degenerative affecting blood vessels in the brain, leading to cognitive impairments. Transcranial direct current stimulation (tDCS), non-invasive brain technique that applies low electrical currents scalp, shows promise treating and movement disorders. However, further clinical evaluation required assess long-term effects of tDCS on neuroplasticity gait patients with CSVD. We investigated long-term, repeated local perfusion, network connectivity, cognition, CSVD disorders (CSVD-GD). This prospective, single-blind, multicenter, randomized controlled study enrolled 66 CSVD-GD, categorized into Sham groups. Imaging characteristic data were collected over three periods using magnetic resonance imaging analyzer, along neuropsychological assessments. Among 156 volunteers participated this study, 60 completing entire process. Compared group, group exhibited more pronounced increase cerebral flow dural cerebrospinal fluid ratio regions such as orbitofrontal cortex cingulate gyrus (P < 0.05, FDR corrected), significantly greater improvements speed stride length. Tolerance was good, no difference adverse reactions between groups, except for scalp burning sensation reported during 1st week (24.24% 6.06% respectively; P = 0.003). Long-term effective safe improving cognition

Language: Английский

Citations

1
Early environmental influences on the orbito-frontal cortex function and its effects on behavior DOI Creative Commons

Olivia Ruge,

João Paulo Maires Hoppe, Roberta Dalle Molle

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106013 - 106013

Published: Jan. 1, 2025

Early-life adversity during pre- and early post-natal phases can impact brain development lead to maladaptive changes in executive behaviors. This increases the risk for a range of psychopathologies physical diseases. Importantly, exposure adversities these periods is also linked alterations orbito-frontal cortex (OFC) which key player functions. The OFC thus appears be central node this association between life stress disease risk. Gaining clear, detailed understanding stress, function, behaviors, as well underlying mechanisms mediating relevant inform potential therapeutic interventions. In paper, we begin by reviewing evidence linking 1) behaviors regulated 2) anatomy function. We then present insights into changes, stemming from models, highlight important future directions line research.

Language: Английский

Citations

1