ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(44), P. 30117 - 30122
Published: Oct. 23, 2024
The
peripheral
nervous
system,
consisting
of
somatic
sensory
circuits
and
autonomic
effector
circuits,
enables
communication
between
the
body's
organs
brain.
Dysregulation
in
these
is
implicated
an
array
disorders
represents
a
potential
target
for
neuromodulation
therapies.
In
this
Perspective,
we
discuss
recent
advances
neurobiological
understanding
brain-body
pathways
expansion
neurotechnologies
beyond
brain
to
viscera.
We
focus
primarily
on
development
integrated
technologies
that
leverage
bioelectronic
devices
with
optogenetic
tools.
highlight
discovery
application
ultrapotent
red-shifted
channelrhodopsins
minimally
invasive
optogenetics
as
tools
study
circuits.
These
innovations
enable
studies
freely
behaving
animals
have
enhanced
our
role
physiological
signals
play
states
behavior.
The Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 22, 2024
Abstract
This
paper
updates
and
builds
on
a
previous
White
Paper
in
this
journal
that
some
of
us
contributed
to
concerning
the
molecular
cellular
basis
cardiac
neurobiology
heart
disease.
Here
we
focus
recent
findings
underpin
autonomic
development,
novel
intracellular
pathways
neuroplasticity.
Throughout
highlight
unanswered
questions
areas
controversy.
Whilst
neurochemical
are
already
demonstrating
prognostic
viability
patients
with
failure,
also
discuss
opportunity
better
understand
sympathetic
impairment
by
using
patient
specific
stem
cells
provides
pathophysiological
contextualization
study
‘disease
dish’.
Novel
imaging
techniques
spatial
transcriptomics
facilitating
road
map
for
target
discovery
may
form
therapeutic
treat
dysautonomia.
image
The Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
602(19), P. 4777 - 4788
Published: March 8, 2024
Abstract
Many
organs
are
designed
to
move:
the
heart
pumps
each
second,
gastrointestinal
tract
squeezes
and
churns
digest
food,
we
contract
relax
skeletal
muscles
move
our
bodies.
Sensory
neurons
of
peripheral
nervous
system
detect
signals
from
bodily
tissues,
including
forces
generated
by
these
movements,
control
physiology.
The
processing
internal
is
called
interoception,
but
this
a
broad
term
that
includes
wide
variety
both
chemical
mechanical
sensory
processes.
Mechanical
senses
understudied,
rapid
progress
has
been
made
in
last
decade,
thanks
part
discovery
mechanosensory
PIEZO
ion
channels
(Coste
et
al.,
2010).
role
mechanosensors
within
interoceptive
focus
review.
In
defining
transduction
molecules
govern
will
have
better
grasp
how
drive
image
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Abstract
Background
and
Aims
The
cholinergic
system
is
distributed
in
the
nervous
system,
mediating
electrical
conduction
through
acetylcholine
(ACh).
This
study
aims
to
identify
whether
heart
possesses
an
intact
endogenous
explore
its
electrophysiological
functions
relationship
with
arrhythmias
both
humans
animals.
Methods
components
of
heart’s
were
identified
by
a
combination
multiple
molecular
cell
biology
techniques.
this
cardiac
was
analysed
Results
An
including
ACh,
ACh
transmitter
vesicles,
transporters,
metabolic
enzymes,
receptors
human
mouse
ventricular
cardiomyocytes
(VCs).
key
significantly
regulated
conductivity
excitation
among
VCs.
influence
on
further
confirmed
mice
α4
or
α7
nicotinic
(nAChRs)
knockouts
monolayers
induced
pluripotent
stem
cell-derived
cardiomyocytes.
Mechanistically,
inward
current
nAChRs
reduce
minimum
threshold
required
generate
action
potential
VCs,
thereby
enhancing
excitability
that
acts
as
prerequisite
for
conduction.
Importantly,
defects
associated
fatal
patients
mice.
Conclusions
identifies
integrated
inherent
heart,
rather
than
external
nerves
can
effectively
control
discovery
reveals
arrhythmia
mechanisms
beyond
classical
theories
opens
new
directions
research.
Science,
Journal Year:
2024,
Volume and Issue:
386(6722)
Published: Nov. 7, 2024
Simultaneous
recordings
from
hundreds
or
thousands
of
neurons
are
becoming
routine
because
innovations
in
instrumentation,
molecular
tools,
and
data
processing
software.
Such
can
be
analyzed
with
science
methods,
but
it
is
not
immediately
clear
what
methods
to
use
how
adapt
them
for
neuroscience
applications.
We
review,
categorize,
illustrate
diverse
analysis
neural
population
describe
these
have
been
used
make
progress
on
longstanding
questions
neuroscience.
review
a
variety
approaches,
ranging
the
mathematically
simple
complex,
exploratory
hypothesis-driven,
recently
developed
more
established
methods.
also
some
common
statistical
pitfalls
analyzing
large-scale
data.
Ageing Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102690 - 102690
Published: Feb. 1, 2025
Aging
strongly
affects
the
peripheral
nervous
system
(PNS),
triggering
alterations
that
vary
depending
on
innervated
tissue.
The
most
frequent
alteration
in
nerve
aging
is
reduced
fiber
and
glial
density
which
can
lead
to
abnormal
functionality.
Interestingly,
activation
of
a
destructive
phenotype
takes
place
macrophages
across
PNS
while
number
neuronal
bodies
unique
feature
some
enteric
ganglia.
Single
cell/nucleus
RNA-sequencing
has
unveiled
striking
complexity
cell
populations
nerves,
these
refined
type
annotations
could
facilitate
better
understanding
aging.
While
effects
senescence
individual
types
requires
further
characterization,
use
senolytics
appears
improve
general
function
models
Here,
we
review
current
age-related
changes
intracardiac,
musculoskeletal,
sub-sections
PNS,
highlighting
their
commonalities
differences.
