Rare-Earth Doping in Nanostructured Inorganic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5519 - 5603

Published: Jan. 6, 2022

Impurity doping is a promising method to impart new properties various materials. Due their unique optical, magnetic, and electrical properties, rare-earth ions have been extensively explored as active dopants in inorganic crystal lattices since the 18th century. Rare-earth can alter crystallographic phase, morphology, size, leading tunable optical responses of doped nanomaterials. Moreover, control ultimate electronic catalytic performance nanomaterials scalable manner, enabling significant improvements energy harvesting conversion. A better understanding critical role prerequisite for development an extensive repertoire functional practical applications. In this review, we highlight recent advances associated applications many fields. This review covers key criteria doping, including basic structures, lattice environments, strategies, well fundamental design principles that enhance electrical, catalytic, magnetic material. We also discuss future research directions challenges controlling

Language: Английский

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J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(49), P. 19221 - 19225

Published: Nov. 20, 2019

Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution vivo optical bioimaging due to decreased scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed improve around it is still a great challenge synthesize organic molecules with absorption emission toward this region. Here, we present J-aggregates 1360 nm 1370 formed by self-assembly of amphiphilic cyanine dye FD-1080 1,2-dimyristoyl-sn-glycero-3-phosphocholine. Molecular dynamics simulations were further employed illustrate process. Superior spatial resolution high signal-to-background ratio demonstrated noninvasive brain hindlimb vasculature nm. The efficacy evaluation clinically used hypotensor successfully achieved dynamic vascular imaging J-aggregates.

Language: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(9), P. 1700 - 1700

Published: Aug. 29, 2020

Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging cancer therapy. They make excellent drug carriers, contrast agents, photothermal photoacoustic radiation dose enhancers, among other applications. Recent advances nanotechnology have led to the use of nanomaterials many areas functional imaging, therapy, synergistic combinational platforms. This review will systematically explore various applications The medical modalities include magnetic resonance computed tomography, positron emission single photon computerized optical ultrasound, imaging. Various therapeutic methods also be included, including photodynamic chemotherapy, immunotherapy. covers theranostics, which same agent diagnosis includes recent multimodality image-guided combination We found that continuous synthesis design novel enhance future development However, more resources should available examine side effects cell toxicity when using humans.

Language: Английский

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Near-infrared luminescence high-contrast in vivo biomedical imaging

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(1), P. 60 - 78

Published: Jan. 19, 2023

Language: Английский

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A materials-science perspective on tackling COVID-19

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(11), P. 847 - 860

Published: Oct. 14, 2020

The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research treatment development. In this Review, we discuss previous efforts developing imaging systems microfluidic devices in-depth real-time investigation viral structures transmission, as well material platforms detection viruses delivery drugs vaccines. We highlight contribution to manufacturing personal protective equipment design simple, accurate low-cost virus-detection devices. then investigate future possibilities development, examining role antiviral-drug design, including synthetic organoids organs-on-a-chip, drug vaccination, production medical equipment. Materials-science-based not only contribute but can also provide understanding, protection, diseases. Materials provides protection against infections, diagnosis, prevention This Review discusses present directions materials-science research, with a focus on COVID-19.

Language: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

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Molecular Fluorophores for Deep-Tissue Bioimaging

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(8), P. 1302 - 1316

Published: July 23, 2020

Fluorescence imaging has made tremendous inroads toward understanding the complexity of biological systems, but in vivo deep-tissue remains a great challenge due to optical opacity tissue. Recent improvements laser and detector manufacturing have allowed expansion nonlinear linear fluorescence underexplored "tissue-transparent" second near-infrared (NIR-II; 1000–1700 nm) window, opening up new opportunities for access deep inside opaque Molecular fluorophores historically played major role bioimaging. It is increasingly important design molecular fully unlock potential NIR-II techniques. In this outlook, we give an overview novel developed bioimaging past five years discuss their pros cons applications. Guidelines designing with desirable properties are also provided.

Language: Английский

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A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(3), P. 1306 - 1312

Published: Sept. 17, 2020

Abstract The design of bright NIR‐II luminescent nanomaterials that enable efficient labelling proteins without disturbing their physiological properties in vivo is challenging. We developed an strategy to synthesize gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size Au NCs (<2 nm) and strong macrocycle‐based host–guest chemistry, as‐synthesized CD‐Au can readily label proteins/antibodies. Moreover, labelled proteins/antibodies highly tracking during blood circulation, biodistribution tumor targeting ability, thus leading a sensitive tumor‐targeted imaging. are stable harsh biological environment show good biocompatibility high renal clearance efficiency. Therefore, biolabels this study provide promising platform monitor behavior biomolecules living organisms.

Language: Английский

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A Tumor‐Microenvironment‐Responsive Lanthanide–Cyanine FRET Sensor for NIR‐II Luminescence‐Lifetime In Situ Imaging of Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(28)

Published: June 3, 2020

Abstract Deep tissue imaging in the second near‐infrared (NIR‐II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to absorption and scattering hampers its application accurate vivo biosensing. Here, lifetime‐based situ hepatocellular carcinoma (HCC) detection NIR‐II region is presented using a tumor‐microenvironment (peroxynitrite, ONOO − )‐responsive lanthanide–cyanine Förster resonance energy transfer (FRET) nanosensor. A specially designed ‐responsive dye, MY‐1057, synthesized as FRET acceptor. Robust lifetime sensing demonstrated be independent of penetration depth. Tumor lesions are accurately distinguished from normal recovery lifetime. Magnetic liver dissection results illustrate reliability single multiple HCC models. Moreover, amount can calculated according standard curve.

Language: Английский

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