The orbitofrontal cortex: reward, emotion and depression

Brain Communications, Journal Year: 2020, Volume and Issue: 2(2)

Published: Jan. 1, 2020

Abstract The orbitofrontal cortex in primates including humans is the key brain area emotion, and representation of reward value non-reward, that not obtaining an expected reward. Cortical processing before about identity stimuli, i.e. ‘what’ present, value. There evidence this holds for taste, visual, somatosensory olfactory stimuli. human medial represents many different types reward, lateral non-reward punishment. Not can lead to sadness, feeling depressed. concept advanced important region depression cortex, with related over-responsiveness over-connectedness non-reward-related under-responsiveness under-connectivity reward-related cortex. Evidence from large-scale voxel-level studies supported by activation study described provides support hypothesis. Increased functional connectivity areas include precuneus, posterior cingulate angular gyrus found patients reduced towards levels controls when treated medication. Decreased temporal lobe involved memory depression. Some treatments may act reducing activity or New increase be useful These concepts, increased attractor networks, have potential advancing our understanding treatment focus on humans, because differences operation indeed systems, rodents. Finally, hypothesis developed has a special role emotion decision-making part as cortical it implement networks maintaining emotional states online, decision-making.

Language: Английский

---

Frontal cortex neuron types categorically encode single decision variables

Nature, Journal Year: 2019, Volume and Issue: 576(7787), P. 446 - 451

Published: Dec. 4, 2019

Language: Английский

---

Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing

Neuron, Journal Year: 2019, Volume and Issue: 103(3), P. 423 - 431.e4

Published: June 10, 2019

Language: Английский

---

Mesolimbic dopamine release conveys causal associations

Science, Journal Year: 2022, Volume and Issue: 378(6626)

Published: Dec. 8, 2022

Learning to predict rewards based on environmental cues is essential for survival. It believed that animals learn by updating predictions whenever the outcome deviates from expectations, and such reward prediction errors (RPEs) are signaled mesolimbic dopamine system-a key controller of learning. However, instead learning prospective RPEs, can infer retrospective cause rewards. Hence, whether conveys a causal associative signal sometimes resembles RPE remains unknown. We developed an algorithm found release associations but not RPE, thereby challenging dominant theory Our results reshape conceptual biological framework

Language: Английский

---

The mouse prefrontal cortex: Unity in diversity

Neuron, Journal Year: 2021, Volume and Issue: 109(12), P. 1925 - 1944

Published: April 23, 2021

Language: Английский

---

Neural dynamics underlying associative learning in the dorsal and ventral hippocampus

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(5), P. 798 - 809

Published: April 3, 2023

Language: Английский

---

Identification of the subventricular tegmental nucleus as brainstem reward center

Science, Journal Year: 2025, Volume and Issue: 387(6732)

Published: Jan. 23, 2025

Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, its prediction activate SVTg, SVTg stimulation leads to place preference, reduced anxiety, accumbal dopamine release. Mice self-stimulate which can also be activated directly by neocortex, resulting in effective inhibition of lateral habenula, region associated with depression. This mechanism may explain why suppression induces aversion increases fear. The translational relevance these findings is supported evidence rat, monkey, human brainstem, establishing key hub processing, emotional valence, motivation.

Language: Английский

---

A neural circuit mechanism for mechanosensory feedback control of ingestion

Nature, Journal Year: 2020, Volume and Issue: 580(7803), P. 376 - 380

Published: April 8, 2020

Language: Английский

---

Transient and Persistent Representations of Odor Value in Prefrontal Cortex

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 209 - 224.e6

Published: Aug. 21, 2020

Language: Английский

---

The orbitofrontal cortex, food intake and obesity

Journal of Psychiatry and Neuroscience, Journal Year: 2020, Volume and Issue: 45(5), P. 304 - 312

Published: Aug. 21, 2020

Obesity is a major health challenge facing many people throughout the world. Increased consumption of palatable, high-caloric foods one drivers obesity. Both orexigenic and anorexic states have been thoroughly reviewed elsewhere; here, we focus on cognitive control feeding in context obesity, how orbitofrontal cortex (OFC) implicated, based data from preclinical clinical research. The OFC important decision-making has heavily researched neuropsychiatric illnesses such as addiction obsessive–compulsive disorder. However, activity only recently described research into food intake, obesity eating disorders. integrates sensory modalities taste, smell vision, it dense reciprocal projections thalamic, midbrain striatal regions to fine-tune decision-making. Thus, may be anatomically functionally situated play critical role etiology maintenance excess behaviour. We propose that serves an integrative hub for orchestrating motivated behaviour suggest its neurobiology functional output might altered obese state.

Language: Английский

---