Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 17(6), P. 338 - 351

Published: March 9, 2020

Language: Английский

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Deep learning tools for the measurement of animal behavior in neuroscience

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 60, P. 1 - 11

Published: Nov. 29, 2019

Language: Английский

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Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 25(11), P. 2742 - 2758

Published: Feb. 21, 2020

Language: Английский

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Optogenetics for light control of biological systems

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: July 21, 2022

Language: Английский

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Improved tools to study astrocytes

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 121 - 138

Published: Feb. 10, 2020

Language: Английский

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Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Nov. 20, 2019

Abstract Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous electrophysiological recording reveal broad cortical correlation patterns, but detailed spatial functional map remains lacking limited resolution. In particular, hemodynamic responses linked to specific activity are unclear at single-vessel level across vasculature, which hinders deciphering of malfunction animal models and translation critical neurovascular coupling (NVC) patterns for human fMRI. We simultaneously acquired optogenetically-driven neuronal Ca 2+ signals blood-oxygen-level-dependent (BOLD) cerebral-blood-volume (CBV)-fMRI from individual venules arterioles. Distinct spatiotemporal were correlated optogenetically evoked spreading depression-like calcium events. The event-related modeling revealed significantly reduced NVC efficiency upon (SDL) events, providing a direct measure function various states.

Language: Английский

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Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 12, 2021

Abstract Neurostimulant drugs or magnetic/electrical stimulation techniques can overcome attention deficits, but these are weakly beneficial in boosting the learning capabilities of healthy subjects. Here, we report a technique, mid-infrared modulation (MIM), that delivers light energy through opened skull even non-invasively thinned intact and activate brain neurons vivo without introducing any exogeneous gene. Using c-Fos immunohistochemistry, single-cell electrophysiology two-photon Ca 2+ imaging mice, demonstrate MIM significantly induces firing activities targeted cortical area. Moreover, mice receive targeting to auditory cortex during an associative task exhibit faster speed (~50% faster) than control mice. Together, this non-invasive, opsin-free technique is demonstrated with potential for modulating neuronal activity.

Language: Английский

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Emerging Modalities and Implantable Technologies for Neuromodulation

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 115 - 135

Published: March 26, 2020

Language: Английский

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Spatiotemporal constraints on optogenetic inactivation in cortical circuits

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Nov. 18, 2019

Optogenetics allows manipulations of genetically and spatially defined neuronal populations with excellent temporal control. However, neurons are coupled other over multiple length scales, the effects localized thus spread beyond targeted neurons. We benchmarked several optogenetic methods to inactivate small regions neocortex. Optogenetic excitation GABAergic produced more effective inactivation than light-gated ion pumps. Transgenic mice expressing light-dependent chloride channel GtACR1 most potent inactivation. Generally, substantially photostimulation light, caused by strong coupling between cortical Over some range light intensity, inhibitory reduced activity in these neurons, together pyramidal a signature inhibition-stabilized neural networks ('paradoxical effect'). The offset was followed rebound dose-dependent manner, limiting resolution. Our data offer guidance for design vivo optogenetics experiments.

Language: Английский

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Deep brain optogenetics without intracranial surgery

Nature Biotechnology, Journal Year: 2020, Volume and Issue: 39(2), P. 161 - 164

Published: Oct. 5, 2020

Language: Английский

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