Modeling traumatic brain and neural injuries: insights from zebrafish DOI Creative Commons
Лада Мурашова, Vyacheslav Dyachuk

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: March 27, 2025

A traumatic injury to the nervous system has significant consequences for mammals, including long-term disability, loss of functions, and neuropathic pain. In contrast zebrafish ( Danio rerio ) exhibits a markedly enhanced neuroregenerative capacity, which can be attributed phenomenon adult neurogenesis distinctive characteristics inflammatory response at site. The post-traumatic recovery under different experimental conditions was demonstrated in numerous studies, substantially advanced our understanding cellular molecular mechanisms neuroregeneration this animal. view differences depending on site, lesion severity, harmful agents, selecting an appropriate model investigations is paramount importance. This review discusses some approaches modeling neural considers effect interactions neurogenesis, with focus animal’s age specific damaging factor that may used select optimum certain lesions.

Language: Английский

Oligodendrocyte precursor cells ingest axons in the mouse neocortex DOI Creative Commons
JoAnn Buchanan, Leila Elabbady, Forrest Collman

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(48)

Published: Nov. 23, 2022

Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by engulfment and degradation axonal branches synapses surrounding glial cells, including microglia astrocytes. However, small size phagocytic organelles complex, highly ramified morphology glia have made it difficult to define contribution these other cell types this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation reconstruct complete 3D morphologies distinct mouse visual cortex, providing unprecedented resolution composition. Unexpectedly, discovered that fine processes oligodendrocyte precursor cells (OPCs), a population abundant, dynamic progenitors, frequently surrounded axons. Numerous phagosomes phagolysosomes (PLs) containing fragments axons vesicular structures were present inside processes, suggesting OPCs engage axon pruning. Single-nucleus RNA sequencing from cortex revealed express key genes at stage, well neuronal transcripts, consistent active engulfment. Although are thought be responsible for majority synaptic pruning refinement, PLs ten times more abundant than markedly less newly generated oligodendrocytes, contribute substantially during cortical development.

Language: Английский

Citations

105
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice DOI Creative Commons

Yohan S. S. Auguste,

Austin Ferro, Jessica A. Kahng

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(10), P. 1273 - 1278

Published: Sept. 28, 2022

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited oligodendrogenesis. Here we show that contribute thalamocortical presynapse elimination in developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases response sensory experience during neural circuit refinement. Our data suggest may regulate synaptic connectivity brain independently

Language: Английский

Citations

103
Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation DOI
Jiaxing Li,

Tania G. Miramontes,

Tim Czopka

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(2), P. 219 - 231

Published: Jan. 12, 2024

Language: Английский

Citations

24
Adaptive and maladaptive myelination in health and disease DOI
Juliet K. Knowles,

Ankita Batra,

Haojun Xu

et al.

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(12), P. 735 - 746

Published: Nov. 14, 2022

Language: Английский

Citations

46
Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling DOI Creative Commons
JoAnn Buchanan, Nuno Maçarico da Costa, Lucas Cheadle

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(8), P. 628 - 639

Published: June 5, 2023

Oligodendrocyte precursor cells (OPCs) are non-neuronal brain that give rise to oligodendrocytes, glia myelinate the axons of neurons in brain. Classically known for their contributions myelination via oligodendrogenesis, OPCs increasingly appreciated play diverse roles nervous system, ranging from blood vessel formation antigen presentation. Here, we review emerging literature suggesting may be essential establishment and remodeling neural circuits developing adult mechanisms distinct production oligodendrocytes. We discuss specialized features position these integrate activity-dependent molecular cues shape wiring. Finally, place within context a growing field focused on understanding importance communication between contexts both health disease.

Language: Английский

Citations

41
Development of myelinating glia: An overview DOI Creative Commons
Carlo D. Cristobal, Hyun Kyoung Lee

Glia, Journal Year: 2022, Volume and Issue: 70(12), P. 2237 - 2259

Published: July 4, 2022

Myelin is essential to nervous system function, playing roles in saltatory conduction and trophic support. Oligodendrocytes (OLs) Schwann cells (SCs) form myelin the central peripheral systems respectively follow different developmental paths. OLs are neural stem-cell derived an intrinsic program resulting a largely irreversible differentiation state. During embryonic development, OL precursor (OPCs) produced distinct waves originating from locations system, with subset developing into myelinating OLs. OPCs remain evenly distributed throughout life, providing population of responsive, multifunctional capacity remyelinate after injury. SCs derive crest, highly dependent on extrinsic signals, have plastic states. SC precursors (SCPs) early nerve structures differentiate multipotent immature (iSCs), which initiate radial sorting non-myelinating SCs. Differentiated retain radically change phenotypes response external including becoming repair SCs, drive regeneration. While several transcription factors components common between their mechanisms distinct, owing unique lineages respective environments. In addition, both respond neuronal activity regulate output reciprocal manners, possibly through pathways. Here, we outline basic programs, regulating differentiation, recent advances field.

Language: Английский

Citations

40
Myelination-independent functions of oligodendrocyte precursor cells in health and disease DOI
Yan Xiao, Tim Czopka

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1663 - 1669

Published: Aug. 31, 2023

Language: Английский

Citations

35
Neurophysiological signatures of cortical micro-architecture DOI Creative Commons
Golia Shafiei, Ben Fulcher, Bradley Voytek

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 26, 2023

Abstract Systematic spatial variation in micro-architecture is observed across the cortex. These micro-architectural gradients are reflected neural activity, which can be captured by neurophysiological time-series. How spontaneous dynamics organized cortex and how they arise from heterogeneous cortical remains unknown. Here we extensively profile regional human brain estimating over 6800 time-series features resting state magnetoencephalography (MEG) signal. We then map profiles to a comprehensive multi-modal, multi-scale atlas of micro-architecture, including microstructure, metabolism, neurotransmitter receptors, cell types laminar differentiation. find that dominant axis reflects characteristics power spectrum density linear correlation structure signal, emphasizing importance conventional electromagnetic while identifying additional informative have traditionally received less attention. Moreover, co-localized with multiple features, gene expression gradients, intracortical myelin, receptors transporters, oxygen glucose metabolism. Collectively, this work opens new avenues for studying anatomical basis activity.

Language: Английский

Citations

33
Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice DOI Creative Commons
Takahiro Shimizu, Stuart G. Nayar, Matthew Swire

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 14, 2023

Abstract Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains adult mice. In present study we ask whether OL production is also required for non-motor cognition, using T-maze radial-arm-maze tasks tax spatial working memory. We find maze training OLP proliferation medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus hippocampal formation male mice; myelin sheath stimulated genu. Genetic blockade differentiation neo-myelination Myrf conditional-knockout mice strongly impairs training-induced improvements performance. a strong positive correlation between performance individual wild type scale during training, but not with number or intensity c-Fos + neurons mPFC, underscoring important role played by lineage cognitive processing.

Language: Английский

Citations

28
Oligodendrocyte precursor cells: the multitaskers in the brain DOI Creative Commons
Li‐Pao Fang, Xianshu Bai

Pflügers Archiv - European Journal of Physiology, Journal Year: 2023, Volume and Issue: 475(9), P. 1035 - 1044

Published: July 4, 2023

Abstract In the central nervous system, oligodendrocyte precursor cells (OPCs) are recognized as progenitors responsible for generation of oligodendrocytes, which play a critical role in myelination. Extensive research has shed light on mechanisms underlying OPC proliferation and differentiation into mature myelin-forming oligodendrocytes. However, recent advances field have revealed that OPCs multiple functions beyond their progenitors, exerting control over neural circuits brain function through distinct pathways. This review aims to provide comprehensive understanding by first introducing well-established features. Subsequently, we delve emerging roles modulating both healthy diseased states. Unraveling cellular molecular influence holds great promise identifying novel therapeutic targets system diseases.

Language: Английский

Citations

25