A Portable, Negative-Pressure Actuated, Dynamically Tunable Microfluidic Droplet Generator DOI Creative Commons
Martin Trossbach,

Marta de Lucas Sanz,

Brinton Seashore‐Ludlow

et al.

Micromachines, Journal Year: 2022, Volume and Issue: 13(11), P. 1823 - 1823

Published: Oct. 25, 2022

Droplet microfluidics utilize a monodisperse water-in-oil emulsion, with an expanding toolbox offering wide variety of operations on range droplet sizes at high throughput. However, translation these capabilities into applications for non-expert laboratories to fully harness the inherent potential microscale manipulations is woefully trailing behind. One major obstacle that microfluidic setups often rely custom fabricated devices, costly liquid actuators, and are not easily set up operated by non-specialists. This impedes wider adoption technologies in, e.g., life sciences. Here, we demonstrate easy-to-use minimal production setup small footprint, built exclusively from inexpensive commercially sourced parts, powered controlled laptop. We characterize components system droplets ranging in volume 3 21 nL single device. Furthermore, describe dynamic tuning composition. Finally, droplet-templated cell spheroids primary cells, where mobility simplicity enables its use within biosafety cabinet. Taken together, believe this ideal drive broad technology.

Language: Английский

Automating interferometric focal length measurement techniques with varifocal optics DOI

Arjent Imeri,

Syed Azer Reza

Optics Communications, Journal Year: 2025, Volume and Issue: unknown, P. 131703 - 131703

Published: March 1, 2025

Language: Английский

Citations

0
Micro/Nanofluidics‐Integrated Biosensors for Respiratory Viral Diseases Diagnosis DOI

Aiswarya Chandrasekaran,

G.H.R. Eranga Karunaratne

Published: May 12, 2025

Language: Английский

Citations

0
Recent development of microfluidics-based platforms for respiratory virus detection DOI Creative Commons
Jingyu Shi, Yu Zhang, Mo Yang

et al.

Biomicrofluidics, Journal Year: 2023, Volume and Issue: 17(2)

Published: March 1, 2023

With the global outbreak of SARS-CoV-2, inadequacies current detection technology for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive assays are needed to expedite diagnosis early intervention. Conventional methods include cell culture-based assays, serological tests, nucleic acid (e.g., RT-PCR), direct immunoassays. However, these traditional often time-consuming, labor-intensive, require laboratory facilities, which cannot meet testing needs, especially during pandemics diseases, such as COVID-19. Microfluidics-based techniques can overcome demerits provide simple, rapid, cost-effective analysis intact virus, viral antigen/antibody, acids. This review aims summarize recent development microfluidics-based viruses. Recent advances in different types microfluidic devices virus diagnostics highlighted, including paper-based microfluidics, continuous-flow droplet-based microfluidics. Finally, future technologies is discussed.

Language: Английский

Citations

9
Optofluidic lasers and their applications in biochemical sensing DOI
Hongrui Zhang, Yanan Zhang, Like Li

et al.

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(13), P. 2959 - 2989

Published: Jan. 1, 2023

This review provides an overview of optofluidic lasers (OFLs), focusing on their constructions, the design OFL-based biochemical sensors and applications in analysis, discusses current challenges future directions.

Language: Английский

Citations

9
The development of droplet-based microfluidic virus detection technology for human infectious diseases DOI

Jiayan Liu,

Bingyang Zhang, Li Wang

et al.

Analytical Methods, Journal Year: 2024, Volume and Issue: 16(7), P. 971 - 978

Published: Jan. 1, 2024

Virus-based human infectious diseases have a significant negative impact on people's health and social development. The need for quick, accurate, early viral infection detection in preventive medicine is expanding. A microfluidic control particularly suitable point-of-care-testing virus diagnosis due to its advantages of low sample consumption, quick speed, simple operation, multi-functional integration, small size, easy portability. It also thought development potential wide range application prospects the research technology. In an effort aid researchers creating novel tools detection, this review highlights recent developments droplet-based microfluidics discusses challenges opportunities rapid detection.

Language: Английский

Citations

3
On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale DOI Creative Commons

Tamar Kurdadze,

Fabrice Lamadie,

Karen A. Nehme

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(5), P. 1529 - 1529

Published: Feb. 27, 2024

Microfluidics has emerged as a robust technology for diverse applications, ranging from bio-medical diagnostics to chemical analysis. Among the different characterization techniques that can be used analyze samples at microfluidic scale, coupling of photonic detection and on-chip configurations is particularly advantageous due its non-invasive nature, which permits sensitive, real-time, high throughput, rapid analyses, taking advantage special environments reduced sample volumes. Putting emphasis on integrated schemes, this review article explores most relevant advances in implementation UV–vis, near-infrared, terahertz, X-ray-based characterizations, punctual spectroscopic or scattering-based measurements types mapping/imaging. The principles their interest are discussed through application systems.

Language: Английский

Citations

3
A Liquid–Solid Contact Electrification Based All‐Optical Liquid Flow Sensor for Microfluidic Analysis in Biomedical Applications DOI
Li Su, Quan Xiong, Yuyan Zhu

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(45)

Published: Sept. 1, 2022

Abstract Liquid flow sensor is an important component of the microfluidic system for analytical science and biomedical systems. However, traditional systems are complex in structure, costly, bulky, generate environmental pollutants. Herein, a novel high‐performance self‐powered all‐optical liquid (ALFS) based on triboelectrification‐induced electroluminescence (TIEL) proposed. The TIEL signal self‐generated real time through contact electrification between polymer–fluid–air surface moving fluid. Moreover, amplitude span electric field can be swiftly altered by adjusting bottom grid electrode layer with appropriate geometric design, so that high sensitivity 0.089 s mm –1 extremely low velocity limit 1 achieved. velocity, volume, composition obtained either observation or optical information extraction from data analysis software. Furthermore, ALFS incorporated into infusion monitor chip applications. This study proposes not only innovative method monitoring but also new rationale coupling triboelectrification which potentially has wide range applications medical, biological, industrial fields.

Language: Английский

Citations

14
One-step immunoassay based on filtration for detection of food poisoning-related bacteria DOI
Hong‐Rae Kim, Ji-Hong Bong, Min‐Jung Kang

et al.

Talanta, Journal Year: 2022, Volume and Issue: 255, P. 124203 - 124203

Published: Dec. 20, 2022

Language: Английский

Citations

13
Caged-Sphere Optofluidic Sensors: Whispering Gallery Resonators in Wicking Microfluidics DOI Creative Commons
Nicolas Riesen, Zane Peterkovic, Bin Guan

et al.

Sensors, Journal Year: 2022, Volume and Issue: 22(11), P. 4135 - 4135

Published: May 29, 2022

The rapid development of optofluidic technologies in recent years has seen the need for sensing platforms with ease-of-use, simple sample manipulation, and high performance sensitivity. Herein, an integrated sensor consisting a pillar array-based open microfluidic chip caged dye-doped whispering gallery mode microspheres is demonstrated shown to have potential real-time monitoring liquids. allows wicking thin film liquid across surface subsequent evaporation-driven flow enabling continuous passive sampling. active placed between pillars, avoid use cumbersome fibre tapers couple light resonators as required microspheres. this using glucose solutions (0.05-0.3 g/mL) response be dynamic reversible. achieves refractive index sensitivity ~40 nm/RIU, Q-factors ~5 × 103 indicating detection limit ~3 10-3 RIU (~20 mg/mL glucose). Further enhancement expected by increasing microsphere Q-factor high-index materials resonators, or alternatively, inducing lasing. sensors are significant host downstream applications, particularly relating point-of-care diagnostics.

Language: Английский

Citations

5
Acoustics-Controlled Microdroplet and Microbubble Fusion and Its Application in the Synthesis of Hydrogel Microspheres DOI
Shaobo Jin, Guoyong Ye, Na Cao

et al.

Langmuir, Journal Year: 2022, Volume and Issue: 38(41), P. 12602 - 12609

Published: Oct. 4, 2022

Droplet fusion technology is a key for many droplet-based biochemical medical applications. By integrating symmetrical flow channel structure, we demonstrate an acoustics-controlled method of microdroplets using surface acoustic waves. Different kinds can be staggered and ordered in the channel, proving good arrangement effect microfluidic chip. This realize not only effective microbubbles but also different sizes without any modification. Further, investigate influence input frequency peak-to-peak value driving voltage on fusion, giving parameter conditions microdroplets. Finally, this successfully used preparation hydrogel microspheres, offering new platform synthesis microspheres.

Language: Английский

Citations

5