Protective Effects of Butyrate on Retinal Neovascularization in Preclinical Retinopathy of Prematurity Models DOI Open Access

Allston Oxenrider,

Tommy Bui,

John Lester

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Abstract Retinopathy of prematurity (ROP) remains a leading cause childhood blindness worldwide, necessitating new therapeutic strategies. Current interventions targeting advanced disease stages often fail to prevent long-term visual impairment. This study investigates the potential sodium butyrate (NaB), an orally administered short-chain fatty acid, in preclinical models ROP. Using oxygen-induced retinopathy (OIR) mouse model, we demonstrate that daily oral NaB supplementation significantly protects against pathological angiogenesis, impacting not only vascular but also neuronal and microglial pathology inner retina. Notably, shows efficacy early-phase ROP intervention, as evidenced by studies post-natal day 9 (P9) OIR mice novel hyperglycemia-associated (HAR) which mimics hyperglycemic conditions many premature infants. These findings highlight promising alternative or adjunct therapy current anti-VEGF treatments, offering protection across multiple retinal cell types development. The underscores need for further research elucidate specific mechanisms NaB’s action, paving way its clinical application management. marks first exploration preventative agent ROP, setting stage additional evaluations optimization. Highlights Sodium (NaB) significant angiogenesis model. impacts highlights intervention (ROP). is investigate

Language: Английский

Research advance about plant polysaccharide prebiotics, benefit for probiotics on gut homeostasis modulation DOI
Xiaoqi Liu,

Shengpeng Su,

Jiaying Yao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103831 - 103831

Published: March 1, 2024

Language: Английский

Citations

19
Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases DOI Open Access
Lucrezia Irene Maria Campagnoli, Angelica Varesi, Annalisa Barbieri

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13338 - 13338

Published: Aug. 28, 2023

The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different body sites, including the gut, oral cavity, skin, eyes. In particular, presence an ocular surface with crucial role maintaining homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline potential association between gut (GM) health. this respect, some evidence supports existence gut-eye axis involved pathogenesis several diseases, age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, glaucoma. Therefore, understanding link GM these disorders might be useful for development new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal transplantation through which could modulated, thus allowing better management diseases.

Language: Английский

Citations

29
How gut microbiota may impact ocular surface homeostasis and related disorders DOI Creative Commons
Marc Labétoulle, Christophe Baudouin,

José Manuel Benítez del Castillo

et al.

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 100, P. 101250 - 101250

Published: March 8, 2024

Changes in the bacterial flora gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those an inflammatory, neuronal, psychological or hormonal factor involved pathogenesis and/or perception of disease. Maintaining ocular surface homeostasis is based on all these four factors, and there accumulating evidence literature relationship between microbiota diseases. The mechanisms mostly interconnected due interaction central peripheral neuronal networks, inflammatory effectors system. A better understanding influence maintenance homeostasis, onset persistence disorders could bring new insights help elucidate epidemiology pathology dynamics health Revealing exact nature associations paramount importance for developing a holistic approach using highly promising therapeutic strategies targeting

Language: Английский

Citations

12
Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43 DOI Creative Commons
Jun Wu, Nu Chen,

Elizabeth Grau

et al.

The Ocular Surface, Journal Year: 2024, Volume and Issue: 32, P. 48 - 57

Published: Jan. 14, 2024

Language: Английский

Citations

8
The Role of Gut Microbiota in Glaucoma Progression and Other Retinal Diseases DOI Open Access

Julie Chen,

Dong Feng Chen, Kin‐Sang Cho

et al.

American Journal Of Pathology, Journal Year: 2023, Volume and Issue: 193(11), P. 1662 - 1668

Published: July 23, 2023

Language: Английский

Citations

22
Gut microbiota and eye diseases: a bibliometric study and visualization analysis DOI Creative Commons
Xiangyu Fu,

Haishan Tan,

Ling Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 9, 2023

Introduction Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot research topic field. Targeting microbiota treat these diseases has become an unstoppable trend. Bibliometric study visualization analysis have essential methods for literature medical We aim depict this area's hotspots future directions by bibliometric software methods. Methods search all related publications from Web Science Core Collection. Then, CiteSpace was applied analyze visualize country distributions, dual-map overlay journals, keyword bursts, co-cited references. VOSviewer employed identify authors, journals display co-occurrence networks. Results A total 284 relevant were identified 2009 2023. The number studies been small first five years grown steadily since 2016. These completed 1,376 authors 41 countries worldwide, with United States lead. Lin P published most papers while Horai R author. top journal are both Investigative Ophthalmology & Visual Science. In network, except microbiota, inflammation becomes highest frequency. Co-citation analyses reveal that involved common immune- inflammation-mediated eye diseases, retinopathy, degeneration, Graves' orbitopathy, microbiomes no longer bacterial populations. Therapeutic strategies target such as probiotics, healthy diet patterns, fecal transplantation, effective critical research. Conclusions conclusion, displays developmental involvement pathogenesis treatment some diseases. It provides overview field's dynamic evolution structural relationships.

Language: Английский

Citations

17
Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation DOI Creative Commons
Junhao Wu, Caihan Duan,

Yuanfan Yang

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 10, 2023

Abstract Maintenance of internal homeostasis is a sophisticated process, during which almost all organs get involved. Liver plays central role in metabolism and involves endocrine, immunity, detoxification storage, therefore it communicates with distant through such mechanisms to regulate pathophysiological processes. Dysfunctional liver often accompanied by pathological phenotypes organs, including the eyes. Many reviews have focused on crosstalk between gut, brain, heart, kidney, but no attention paid In this review, we summarized intimate connections eyes from three aspects. Epidemiologically, suggest liver-related, potential, protective risk factors for typical eye disease as well indicators connected status. For molecular mechanism aspect, elaborate their inter-organ (glucose, lipid, proteins, vitamin, mineral), (ammonia bilirubin), immunity (complement inflammation regulation) aspect. clinical application part, emphasize latest advances utilizing liver-eye axis diagnosis therapy, involving artificial intelligence-deep learning-based novel diagnostic tools detecting adeno-associated viral vector-based gene therapy method curing blinding disease. We aim focus provide insights into communications help resolve existed clinically significant issues.

Language: Английский

Citations

13
Postbiotics: emerging therapeutic approach in diabetic retinopathy DOI Creative Commons
Qin Chen,

Xuejian Li,

Wei Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, limited therapeutic effectiveness, extremely important find new strategy for DR. Postbiotic an emerging dietary supplement which consists inactivate microbiota its metabolites. Numerous animal experiments have demonstrated intervention with postbiotics reduces hyperglycemia, attenuates retinal peripapillary endothelial cell damage, improves microcirculatory dysfunction, consequently delays progression More strikingly, unlike conventional probiotics prebiotics, small molecules directly colonize intestinal epithelial cells, exert heat-resistant, acid-resistant, durable storage. Despite few clinical significance, oral administration might become effective management prevention In this review, we summarized basic conception, classification, molecular mechanisms, advances implications pathogenesis Postbiotics present great potential viable adjunctive therapy

Language: Английский

Citations

4
Gut Microbiota on Anxiety and Depression in Primary Sjogren's Syndrome: A Novel Insight DOI Creative Commons
Zhu Ying, Kaiyuan Zhang, Ziyue Luo

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42045 - e42045

Published: Jan. 18, 2025

Primary Sjogren's syndrome (pSS) is a prevalent disease in rheumatology and immunology. Anxiety, depression, other mood disorders are pervasive across diverse sectors of society. Recent theories on the gut-brain axis have elucidated that gut microbiota considered second brain humans, can modulate central nervous system behavior by mediating bidirectional response systems, including immunity, vagus nerve, neuroendocrine pathways. This article reviews recent advancements explore mechanism between emotional pSS. It aims to provide novel therapies for these

Language: Английский

Citations

0
Antibiotic-Induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice DOI Creative Commons
Xinwei Jiao, Yán Li,

Yu Hu

et al.

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0