Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy

Biomaterials, Journal Year: 2019, Volume and Issue: 223, P. 119479 - 119479

Published: Sept. 6, 2019

Language: Английский

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Advancing antimicrobial strategies for managing oral biofilm infections

International Journal of Oral Science, Journal Year: 2019, Volume and Issue: 11(3)

Published: Sept. 1, 2019

Abstract Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling biofilm-related infections published predominantly over the past 5 years. Antimicrobial dental materials based on agent release, contact-killing and multi-functional have been designed synthesized prevention initial bacterial attachment subsequent formation tooth material surface. Among therapeutic approaches managing clinical practice, photodynamic therapy has emerged as an alternative to regimes mechanical removal biofilms, cold atmospheric plasma shows significant advantages conventional approaches. Nevertheless, more preclinical studies appropriately well-structured multi-center trials are critically needed obtain reliable comparative data. acquired information will be helpful identifying most effective antibacterial solutions optimal circumstances utilize these strategies.

Language: Английский

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Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Biomacromolecules, Journal Year: 2019, Volume and Issue: 20(7), P. 2441 - 2463

Published: May 22, 2019

Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, premature aging. By taking advantage of the discrepancy levels between normal diseased tissues, a variety ROS-sensitive moieties or linkers have been developed design ROS-responsive systems for site-specific delivery drugs genes. In this review, we summarized chemical structures, mechanisms, systems, focusing on their current advances precise drug/gene delivery. particular, nanocarriers, prodrugs, supramolecular hydrogels are terms application delivery, common strategies elevate diminish cellular concentrations, as well recent development ROS-related imaging probes were also discussed.

Language: Английский

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Carbohydrate-Based Macromolecular Biomaterials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 10950 - 11029

Published: Aug. 2, 2021

Carbohydrates are the most abundant and one of important biomacromolecules in Nature. Except for energy-related compounds, carbohydrates can be roughly divided into two categories: as matter information. As matter, abundantly present extracellular matrix animals cell walls various plants, bacteria, fungi, etc., serving scaffolds. Some commonly found polysaccharides featured biocompatible materials with controllable rigidity functionality, forming polymeric biomaterials which widely used drug delivery, tissue engineering, etc. information, usually referred to glycans from glycoproteins, glycolipids, proteoglycans, bind proteins or other carbohydrates, thereby meditating cell–cell cell–matrix interactions. These could simplified synthetic glycopolymers, afforded through polymerization, multistep synthesis, a semisynthetic strategy. The information role demonstrated not only targeting reagents but also immune antigens adjuvants. latter included this review they always macromolecular formulation. In review, we intend provide relatively comprehensive summary carbohydrate-based since 2010 while emphasizing fundamental understanding guide rational design biomaterials. Carbohydrate-based macromolecules on basis their resources chemical structures will discussed, including naturally occurring polysaccharides, derived glycopolymers/glycodendrimers, supramolecular glycolipids/glycoproteins. Multiscale structure–function relationships several major application areas, delivery systems, immunology, detailed. We hope valuable development build bridge between promote new biomaterial near future.

Language: Английский

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Nanotechnology-based biomaterials for orthopaedic applications: Recent advances and future prospects

Materials Science and Engineering C, Journal Year: 2019, Volume and Issue: 106, P. 110154 - 110154

Published: Sept. 2, 2019

Language: Английский

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Biofilm‐Sensitive Photodynamic Nanoparticles for Enhanced Penetration and Antibacterial Efficiency

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(33)

Published: June 16, 2021

Abstract Efficient antimicrobials are urgently needed for the treatment of bacterial biofilms due to their resistance traditional drugs. Photodynamic therapy (PDT) is a new strategy that has been used combat bacteria and biofilms. Cationic photosensitizers, particularly cationic photodynamic nanoagents, usually chosen enhance antimicrobial activity. However, positively charged nanoparticles (NPs) beneficial cellular internalization, which causes increased cell cytotoxicity. Herein, pH‐sensitive nanosystem designed. Rose Bengal (RB) polydopamine (PDA) NPs decorated in layer‐by‐layer fashion with polymyxin B (PMB) gluconic acid (GA) generate functionally adaptive (RB@PMB@GA NPs). RB@PMB@GA remain negative at physiological pH exhibit good biocompatibility. When exposed an acidic infectious environment, surface charge is, turn, as result electrostatic interactions. This conversion allows effectively bind surfaces photoinactivation efficiency against gram‐negative bacteria. Most importantly, biofilm penetration eradication under conditions. Furthermore, efficiently eliminate infections vivo. study provides promising safely treating biofilm‐associated

Language: Английский

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Niobium Carbide MXene Augmented Medical Implant Elicits Bacterial Infection Elimination and Tissue Regeneration

ACS Nano, Journal Year: 2020, Volume and Issue: 15(1), P. 1086 - 1099

Published: Dec. 29, 2020

Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic resistance are among the most dangerous threats for humans. With few effective strategies available in antimicrobial antibiofilm development, innovative methodologies inspired by advances other fields such as nanomedicine becoming more attractive to realize antibacterial agents. Herein, a 2D niobium carbide (Nb2C) MXene titanium plate (Nb2C@TP)-based clinical implant with practical multimodal anti-infection functions was developed. Such emerging modes capable of destroying biofilms direct bacteria elimination through down-regulating energy metabolism pathways, suppressing biofilm formation, enhancing as-formed detachment via an activating accessory gene regulator. Another intriguing feature this is sensitization ability toward photothermal transduction, which reduces temperature necessary eradication mitigates possible normal tissue damage. Moreover, Nb2C@TP medical able alleviate proinflammatory responses scavenging excessive reactive oxygen species infectious microenvironments, benefiting angiogenesis remodeling.

Language: Английский

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Combating Implant Infections: Shifting Focus from Bacteria to Host

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(43)

Published: Sept. 11, 2020

Abstract The widespread use of biomaterials to support or replace body parts is increasingly threatened by the risk implant‐associated infections. In quest for finding novel anti‐infective biomaterials, there generally has been a one‐sided focus on with direct antibacterial properties, which leads excessive agents, compromised host responses, and unpredictable effectiveness in vivo. This review sheds light how immunomodulation, rather than only targeting bacteria, can endow improved properties. How surface treatments are at be undermined biomaterial features that dysregulate protection normally provided critical immune cell subsets, namely, neutrophils macrophages, discussed. Accordingly, precise modification biophysical cues, incorporation immunomodulatory drug delivery systems, render necessary immune‐compatible immune‐protective properties potentiate defense mechanisms reviewed. Within this context, protective role peptides, metallic particles, quorum sensing inhibitors, therapeutic adjuvants highlighted strategies may lay foundation develop while mitigating increasing threat resistance.

Language: Английский

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Nanoparticles for Oral Biofilm Treatments

ACS Nano, Journal Year: 2019, Volume and Issue: 13(5), P. 4869 - 4875

Published: April 29, 2019

Pathogenic oral biofilms are universal, chronic, and costly. Despite advances in understanding the mechanisms of biofilm formation persistence, novel effective treatment options remain scarce. Nanoparticle-mediated eradication matrix resident bacteria holds great potential. In particular, nanoparticles that target specific microbial features utilizing nontoxic materials well-suited for clinical translation. However, much work remains to characterize local systemic effects therapeutic agents topically applied chronic biofilms, such as those cause dental caries. this Perspective, we summarize pathogenesis describe current future nanoparticle-mediated approaches, highlight outstanding questions paramount answer effectively targeting treating biofilms.

Language: Английский

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Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 7

Published: Jan. 9, 2020

Many nanotechnology-based antimicrobials and antimicrobial-delivery-systems have been developed over the past decades with aim to provide alternatives antibiotic treatment of infectious-biofilms across human body. Antimicrobials can be loaded into nanocarriers protect them against de-activation, reduce their toxicity potential, harmful side-effects. Moreover, antimicrobial such as micelles, equipped stealth pH-responsive features that allow self-targeting accumulation in at high concentrations. Micellar liposomal differ hydrophilicity outer-surface inner-core. Micelles are self-assembled, spherical core-shell structures composed single layers surfactants, hydrophilic head-groups hydrophobic tail-groups pointing micellar core. Liposomes lipids, self-assembled bilayers. The head lipids determines surface properties liposomes, while tail, internal bilayer, fluidity liposomal-membranes. Therefore, whereas micelles only antimicrobials, encapsulated hydrophilic, aqueous core liposomes or amphiphilic inserted phospholipid bilayer. Nanotechnology-derived prepared diameters <100-200 nm, required prevent reticulo-endothelial rejection penetration infectious-biofilms. However, surface-functionalization is considerably more difficult than which explains self-targeting, find way through blood circulation toward still challenging prepare. Equally, development penetrate entire thickness biofilms deep killing biofilm inhabitants provides a challenge. bilayer easily fuses bacterial cell membranes release antimicrobial-doses directly inside bacteria. Arguably, protection de-activation antibiotics fusogenicity constitute biggest advantage carriers free solution. Gram-negative Gram-positive strains, resistant specific antibiotics, demonstrated susceptible these when nanocarriers. Recently, also progress has made concerning large-scale production long-term storage liposomes. Therewith, remaining challenges develop penetrate, accumulate kill deeply remain worthwhile pursue.

Language: Английский

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