An Investigation into the Intrinsic Peroxidase‐Like Activity of Fe‐MOFs and Fe‐MOFs/Polymer Composites DOI
Bhawana Thakur, Vikram V. Karve, Daniel T. Sun

et al.

Advanced Materials Technologies, Journal Year: 2021, Volume and Issue: 6(5)

Published: March 24, 2021

Abstract The quest for developing materials that provide a perfect trade‐off between factors such as enzyme‐like response, stability, and low cost has been long‐standing challenge in the field of biosensing. Metal‐organic frameworks (MOFs) their composites have emerged promising candidates biosensing applications due to exceptional properties tunable pore size, high specific surface area, exposed active sites. A comparative study intrinsic peroxidase‐like activity five different MOF materials: Fe‐BTC, NH 2 ‐MIL‐101(Fe), Fe‐BTC with polymers polydopamine (PDA), poly p‐phenylenediamine (PpPDA), poly(3,4‐ethylenedioxythiophene) is reported detection H O , an important biomarker biomedical diagnostics. response these toward via electrochemical colorimetric techniques mapped it found that, at neutral pH, Fe‐BTC/PEDOT composite exhibits highest sensitivity compared other this study. results indicate combination unique conducting polymer PEDOT, improves individual components. This work presents new opportunity easy‐to synthesize low‐cost MOFs/conducting provides significant insights achieve rational design desirable functional

Language: Английский

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System DOI Open Access
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5954 - 5954

Published: May 25, 2022

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role information transmission throughout the nervous system. Hundreds of such chemicals have been discovered last century, continuing to be identified studied concerning their action on brain health. These substances observed influence numerous functions, including emotions, thoughts, memories, learning, movements. Thus, disturbances neurotransmitters' homeostasis started being correlated with a plethora neurological neurodegenerative disorders. In this respect, present paper aims describe most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) noncanonical neurotransmitters exosomes, steroids, D-aspartic acid), explain link some relevant conditions. Moreover, brief overview recently developed detection methods is offered, followed by several considerations modulation these towards restoring homeostasis.

Language: Английский

Citations

275
Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators DOI
Zhaofa Wu, Dayu Lin, Yulong Li

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(5), P. 257 - 274

Published: March 31, 2022

Language: Английский

Citations

163
Semiconducting Polymers for Neural Applications DOI Creative Commons
Ivan B. Dimov, Maximilian Moser, George G. Malliaras

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(4), P. 4356 - 4396

Published: Jan. 28, 2022

Electronically interfacing with the nervous system for purposes of health diagnostics and therapy, sports performance monitoring, or device control has been a subject intense academic industrial research decades. This trend only increased in recent years, numerous high-profile initiatives commercial endeavors. An important theme emerged as result, which is incorporation semiconducting polymers various devices that communicate system─from wearable brain-monitoring caps to penetrating implantable microelectrodes. driven by potential this broad class materials improve electrical mechanical properties tissue–device interface, along possibilities biocompatibility. In review we first begin tutorial on neural interfacing, reviewing basics function, physics, neuroelectrophysiological techniques their demands, finally give brief perspective how material improvements can address current deficiencies system. The second part detailed past work polymers, covering properties, structure, synthesis, processing.

Language: Английский

Citations

114
Skin-inspired soft bioelectronic materials, devices and systems DOI
Chuanzhen Zhao, Jaeho Park, Samuel E. Root

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(8), P. 671 - 690

Published: June 17, 2024

Language: Английский

Citations

81
Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review DOI
Vahulabaranan Rajagopalan,

Swethaa Venkataraman,

Devi Sri Rajendran

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 227, P. 115724 - 115724

Published: March 21, 2023

Language: Английский

Citations

56
2D Transition Metal Carbides (MXene) for Electrochemical Sensing: A Review DOI
Faisal Shahzad, Shabi Abbas Zaidi, Rizwan Ali Naqvi

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2020, Volume and Issue: 52(4), P. 848 - 864

Published: Oct. 27, 2020

MXene, a novel class of 2-dimensional transition metal carbides has evolved as promising material for various applications owing to its outstanding characteristics such hydrophilicity, high electrical conductivity, surface area, and attractive topological structure. MXenes can form dispersion in common solvents constitute composite with other nanomaterials, which be utilized effective transducers molecular sensing. MXene-modified support materials, thus provide an intriguing platform immobilization target molecules onto their surface. The literature reveals that it been increasingly the sensing diverse types analytes including glucose, pharmaceuticals, metals dyes, cancer markers, pesticides, neurotransmitters, small valuable molecules, so on. In this review, we summarize recent updates MXene modified materials For convenience our audience, have distributed into categories discussed them comprehensively. Not only present synthesis approach, electrochemical properties chemistry but also briefly current challenges outlook future research related area.

Language: Английский

Citations

105
Electrochemical Detection of Neurotransmitters DOI Creative Commons
Saikat Banerjee,

Stephanie McCracken,

Md Faruk Hossain

et al.

Biosensors, Journal Year: 2020, Volume and Issue: 10(8), P. 101 - 101

Published: Aug. 18, 2020

Neurotransmitters are important chemical messengers in the nervous system that play a crucial role physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, neurodegenerative diseases such as Alzheimer's, Parkinson's, dementia, addiction, depression, schizophrenia. Although multiple neurotechnological approaches reported literature, detection monitoring brain remains challenge continues to garner significant attention. Neurotechnology provides high-throughput, well fast specific quantification target analytes brain, without negatively impacting implanted region is highly desired for complex intercommunication neurotransmitters. Therefore, it develop clinical assessment techniques sensitive reliable monitor modulate these screen diseases. This review focuses on summarizing current electrochemical measurement capable sensing high temporal resolution real time. Advanced neurotransmitter platforms integrate nanomaterials biorecognition elements explored.

Language: Английский

Citations

100
Addressing the Selectivity of Enzyme Biosensors: Solutions and Perspectives DOI Creative Commons
Bogdan Bucur, Cristina Purcărea, Silvana Andreescu

et al.

Sensors, Journal Year: 2021, Volume and Issue: 21(9), P. 3038 - 3038

Published: April 26, 2021

Enzymatic biosensors enjoy commercial success and are the subject of continued research efforts to widen their range practical application. For these reach full potential, selectivity challenges need be addressed by comprehensive, solid approaches. This review discusses status enzymatic in achieving accurate selective measurements via direct biocatalytic inhibition-based detection, with a focus on electrochemical enzyme biosensors. Examples solutions for tackling activity problems preventing interferences from co-existing electroactive compounds samples provided such as use permselective membranes, sentinel sensors coupled multi-enzyme systems. The effect activators, inhibitors or substrates also reactions multi-sensor arrays combined data interpretation chemometrics. In addition more traditional approaches, some ingenious recent detailing possible involving nanomaterials ensuring biosensors' selectivity. Overall, examples presented illustrate various tools available when developing new applications stress necessity comprehensively investigate validate versus standard analytical methods.

Language: Английский

Citations

61
Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience DOI

Ryma Boudries,

Hannah Williams,

Soraya Paquereau--Gaboreau

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22620 - 22647

Published: Aug. 1, 2024

Monitoring neurochemicals and imaging the molecular content of brain tissues

Language: Английский

Citations

9
Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing DOI Creative Commons

Umisha Siwakoti,

Steven A. Jones, Deepak Kumbhare

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 100 - 100

Published: Feb. 10, 2025

Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales regions. Microelectrode arrays (MEAs) are widely used record neurophysiological activity various depths regions, providing single-unit resolution for extended periods. Recent advancements in flexible MEAs, built on micrometer-thick polymer substrates, have improved integration with tissue by mimicking the brain's soft nature, reducing mechanical trauma inflammation. These flexible, subcellular-scale MEAs can stable signals months, making them ideal long-term studies. In addition recording, been functionalized electrochemical neurotransmitter detection. Electroactive neurotransmitters, such as dopamine, serotonin, adenosine, be directly measured via methods, particularly carbon-based surfaces. For non-electroactive neurotransmitters like acetylcholine, glutamate, γ-aminobutyric acid, alternative strategies, enzyme immobilization aptamer-based recognition, employed generate signals. This review highlights recent developments MEA fabrication functionalization achieve both electrophysiological recordings, minimizing sensor fowling damage when implanted long-term. It covers multi-time scale detection, development of conducting nanomaterial composite coatings enhance sensitivity, incorporation recognition carbon electrodes MEAs. Finally, it summarizes strategies acquire measurements from same device.

Language: Английский

Citations

1