The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 191, P. 114614 - 114614

Published: Nov. 5, 2022

Language: Английский

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Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy

Biomaterials, Journal Year: 2020, Volume and Issue: 240, P. 119902 - 119902

Published: Feb. 18, 2020

Language: Английский

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Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Biomaterials, Journal Year: 2019, Volume and Issue: 232, P. 119700 - 119700

Published: Dec. 18, 2019

Language: Английский

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Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(22)

Published: March 29, 2020

Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with ability to exploit unique characteristics microenvironment for precise targeting have been designed. To activate nanoparticles, various bio-physicochemical microenvironment, namely, acidic pH, redox reactants, and hypoxia, are exploited. Stimuli-responsive also utilize excessive presence adenosine triphosphate (ATP), riboflavin, Zn2+ in tumors. An overview design stimulus-responsive that precisely target respond tumors via intracellular signals is provided. Detailed will result more effective clinical translation.

Language: Английский

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A critical review of synthesis procedures, applications and future potential of nanoemulsions

Advances in Colloid and Interface Science, Journal Year: 2020, Volume and Issue: 287, P. 102318 - 102318

Published: Nov. 12, 2020

Language: Английский

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Gold nanoclusters for theranostic applications

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 431, P. 213689 - 213689

Published: Dec. 5, 2020

Language: Английский

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Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

Asian Journal of Pharmaceutical Sciences, Journal Year: 2020, Volume and Issue: 16(1), P. 24 - 46

Published: May 12, 2020

In the last decade, use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held great attention. Up to date, several approaches have been employed in order develop smart nanotheranostics, which combine bioactive targeting on specific tissues well properties. The can deliver agents by concomitantly monitor therapy response real-time. Consequently, possibility over- or under-dosing decreased. Various non-invasive imaging techniques used quantitatively drug delivery processes. Radiolabeling nanomaterials widely powerful approach nuclear medicine imaging. fact, radiolabeled designed developed tumors other lesions due their efficient characteristics. Inorganic nanoparticles gold, silver, silica based organic polymers, carbon nanomaterials, liposomes reported multifunctional nanotheranostics. this review, modalities according diseases are summarized, providing special details radiolabeling. further, most current categorized via also summed up. To conclude, review be beneficial medical pharmaceutical society material scientists who work field since they research guide producing newer more

Language: Английский

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Functionalized MoS₂-Based Nanomaterials for Cancer Phototherapy and Other Biomedical Applications

ACS Materials Letters, Journal Year: 2021, Volume and Issue: 3(5), P. 462 - 496

Published: March 29, 2021

Transition-metal dichalcogenides (TMDs), as a novel category of nanomaterials and potential alternate to graphene, are attracting great interest researchers, because their strong conductivity, superior catalytic performance, good optical properties. As the most representative type all TMDs, molybdenum disulfide (MoS2)-based expanded into two-dimensional (2D) nanosheets, quantum dots (QDs), flower-like nanoparticles, nanospheres nanotubes. These types regarded promising nanoplatforms for various applications in biomedicine, such drug delivery, phototherapy, biosensing, bioimaging, theranostics, antimicrobials, unique planar structures, superb electronic properties (such thickness-dependent bandgap, near-infrared absorbance, large surface area), easily functionalized sites. Until now, there have been few reviews about MoS2-based nanomaterials, with regard functionalization improvement properties, high loading efficiency, dispersibility, physiological stability, biocompatibility, targeting ability, pharmacodynamics, controllable release, enhanced treatment therapeautic efficacy, even biodegradability toxicity reduction. Here, we systematically summarized progress improved physicochemical biological biomedical applications. First, emphatically introduced these anticancer photothermal therapy (PTT), photodynamic (PDT), combined phototherapy. Besides, other were also detail including toxicity, tissue engineering, antimicrobials. Lastly, current challenges, opportunities prospects discussed depth. We expect that this review will contribute quick in-depth understanding latest bioapplication inspiring creation techniques design fabricate multiple capability safety, expand them more application field biomedicine.

Language: Английский

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Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 29 - 48

Published: Jan. 19, 2022

Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to wide range of treatments applications, as demonstrated preclinical and clinical studies. However, the broad applications biotherapy have been limited by critical challenges, including lack safe efficient delivery systems serious side effects. Due unique potentials biomaterials, such good biocompatibility bioactive properties, biomaterial-assisted be an attractive strategy. The biomaterial-based possess sufficient packaging capacity versatile functions, enabling sustained localized release drugs at target sites. Furthermore, biomaterials can provide niche specific extracellular conditions for proliferation, differentiation, attachment, migration stem cells, leading tissue regeneration. In this review, state-of-the-art studies on biotherapy, drug delivery, vaccine development, gene therapy, cell summarized. challenges outlook biotherapies also discussed.

Language: Английский

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Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 4, 2022

Abstract Chemotherapy remains one of the most prevailing regimens hitherto in fight against cancer, but its development has been being suffering from various fatal side effects associated with non-specific toxicity common chemical drugs. Advances biomedical application nanomedicine have providing alternative promising approaches for cancer therapy, by leveraging excellent intrinsic physicochemical properties to address these critical concerns. In particular, nanomedicine-enabled chemotherapy established as a safer and therapeutic modality, especially recently proposed nanocatalytic medicine featuring capabilities generate toxic substances initiating diverse catalytic reactions within tumor without directly relying on highly non-selective chemotherapeutic agents. Of special note, under exogenous/endogenous stimulations, can serve versatile platform that allows additional modalities (photothermal therapy (PTT), photodynamic (PDT), chemodynamic (CDT), etc.) be seamlessly integrated efficacious synergistic treatments tumors. Here, we comprehensively review summarize representative studies multimodal derived medicine-enabled recent years, their underlying mechanisms are also presented detail. A number existing challenges further perspectives nanomedicine-synergized malignant solid highlighted understanding this booming research area possible. Graphical

Language: Английский

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