Small,
Journal Year:
2021,
Volume and Issue:
17(8)
Published: Feb. 1, 2021
Abstract
Invoking
the
occurrence
of
pyroptosis
is
an
emerging
strategy
for
treatment
cancer.
However,
practical
applications
cancer
therapy
are
currently
hindered
due
to
lack
tumor‐specific
and
efficient
pyroptotic
agents
in
vivo.
Herein,
a
virus‐spike
tumor‐activatable
agent
(VTPA)
cancer‐specific
reported.
The
VTPA
composed
organosilica
coated
iron
oxide
nanoparticle
core
spiky
manganese
dioxide
protrusions,
which
can
readily
accumulate
tumor
after
systemic
administration,
facilitate
intracellular
lysosomal
rupture,
be
degraded
by
over‐expressed
glutathione
(GSH)
release
Mn
ions
nanoparticles
(IONPs)
synergetic
activation
nucleotide
binding
oligomerization
domain‐like
receptors
protein
3
(NLRP3)
inflammasomes.
Consequently,
NLRP3
inflammasomes
lactate
dehydrogenase
cells
observed
VTPA,
resulting
specific
cell
death.
To
our
best
knowledge,
structure‐dependent
GSH
activatable
represent
first
demonstration
vivo,
providing
novel
paradigm
development
next‐generation
nanomedicine.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5519 - 5603
Published: Jan. 6, 2022
Impurity
doping
is
a
promising
method
to
impart
new
properties
various
materials.
Due
their
unique
optical,
magnetic,
and
electrical
properties,
rare-earth
ions
have
been
extensively
explored
as
active
dopants
in
inorganic
crystal
lattices
since
the
18th
century.
Rare-earth
can
alter
crystallographic
phase,
morphology,
size,
leading
tunable
optical
responses
of
doped
nanomaterials.
Moreover,
control
ultimate
electronic
catalytic
performance
nanomaterials
scalable
manner,
enabling
significant
improvements
energy
harvesting
conversion.
A
better
understanding
critical
role
prerequisite
for
development
an
extensive
repertoire
functional
practical
applications.
In
this
review,
we
highlight
recent
advances
associated
applications
many
fields.
This
review
covers
key
criteria
doping,
including
basic
structures,
lattice
environments,
strategies,
well
fundamental
design
principles
that
enhance
electrical,
catalytic,
magnetic
material.
We
also
discuss
future
research
directions
challenges
controlling
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Feb. 21, 2023
Abstract
Lung
cancer
is
the
primary
cause
of
mortality
in
United
States
and
around
globe.
Therapeutic
options
for
lung
treatment
include
surgery,
radiation
therapy,
chemotherapy,
targeted
drug
therapy.
Medical
management
often
associated
with
development
resistance
leading
to
relapse.
Immunotherapy
profoundly
altering
approach
owing
its
tolerable
safety
profile,
sustained
therapeutic
response
due
immunological
memory
generation,
effectiveness
across
a
broad
patient
population.
Different
tumor-specific
vaccination
strategies
are
gaining
ground
cancer.
Recent
advances
adoptive
cell
therapy
(CAR
T,
TCR,
TIL),
clinical
trials
on
cancer,
hurdles
discussed
this
review.
patients
(without
targetable
oncogenic
driver
alteration)
reveal
significant
responses
when
treated
programmed
death-1/programmed
death-ligand
1
(PD-1/PD-L1)
checkpoint
blockade
immunotherapies.
Accumulating
evidence
indicates
that
loss
effective
anti-tumor
immunity
tumor
evolution.
vaccines
combined
immune
inhibitors
(ICI)
can
achieve
better
effects.
To
end,
present
article
encompasses
detailed
overview
recent
developments
immunotherapeutic
landscape
targeting
small
(SCLC)
non-small
(NSCLC).
Additionally,
review
also
explores
implication
nanomedicine
immunotherapy
as
well
combinatorial
application
traditional
along
regimens.
Finally,
ongoing
trials,
obstacles,
future
outlook
strategy
highlighted
boost
further
research
field.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 2005 - 2037
Published: Feb. 10, 2021
Single-atom
catalysts
(SACs)
featuring
the
complete
atomic
utilization
of
metal,
high-efficient
catalytic
activity,
superior
selectivity,
and
excellent
stability
have
been
emerged
as
a
frontier
in
field.
Recently,
increasing
interests
drawn
to
apply
SACs
biomedical
fields
for
enzyme-mimic
catalysis
disease
therapy.
To
fulfill
demand
precision
personalized
medicine,
precisely
engineering
structure
active
site
toward
levels
is
trend
nanomedicines,
promoting
evolution
metal-based
nanomaterials,
particularly
biocatalytic
from
nanoparticles
clusters
now
SACs.
This
review
outlines
syntheses,
characterizations,
mechanisms
metal
SACs,
with
focus
on
their
applications
including
biosensing,
antibacterial
therapy,
cancer
well
an
emphasis
vivo
biological
safeties.
Challenges
future
perspectives
are
ultimately
prospected
diverse
applications.
Nano Convergence,
Journal Year:
2021,
Volume and Issue:
8(1)
Published: Nov. 2, 2021
Modern
medicine
has
been
waging
a
war
on
cancer
for
nearly
century
with
no
tangible
end
in
sight.
Cancer
treatments
have
significantly
progressed,
but
the
need
to
increase
specificity
and
decrease
systemic
toxicities
remains.
Early
diagnosis
holds
key
improving
prognostic
outlook
patient
quality
of
life,
diagnostic
tools
are
cusp
technological
revolution.
Nanotechnology
steadily
expanded
into
reaches
chemotherapy,
radiotherapy,
diagnostics,
imaging,
demonstrating
capacity
augment
each
advance
care.
Nanomaterials
provide
an
abundance
versatility,
functionality,
applications
engineer
specifically
targeted
medicine,
accurate
early-detection
devices,
robust
imaging
modalities,
enhanced
radiotherapy
adjuvants.
This
review
provides
insights
current
clinical
pre-clinical
nanotechnological
drug
therapy,
radiation
therapy.
Accounts of Chemical Research,
Journal Year:
2020,
Volume and Issue:
53(11), P. 2692 - 2704
Published: Oct. 26, 2020
ConspectusOwing
to
their
unique
features,
the
past
decade
has
witnessed
rapid
developments
of
lanthanide-activated
nanoparticles
for
biological
applications.
These
include
highly
tunable
upconverting
and
downshifting
photoluminescence
when
illuminated
in
deep
tissue,
excellent
photostability
against
blinking
bleaching
effects,
biocompatibility
through
versatile
surface
modification,
ease
achieving
multifunctionality,
as
well
satisfactory
signal
output.
attributes
make
lanthanide-doped
an
ideal
toolbox
advanced
bioimaging
next-generation
therapeutics.The
interest
biomedical
research
arises
from
optical
properties
response
deep-tissue-penetrable
light
sources.
Upon
near-infrared
irradiation,
these
with
properly
doped
emitters
display
photon
upconversion
large
anti-Stokes
shifts
broad-spectrum
tunability
ultraviolet
visible.
It
is
also
possible
achieve
orthogonal
variations
wavelength
lifetime.
Coupled
ligands,
dyes,
biomolecules,
or
other
types
functional
nanomaterials,
offer
new
opportunities
applications
bioimaging,
oncotherapy,
neuromodulation.
Given
possibility
locating
luminescence
at
"biological
transmission
windows",
exquisite
design
enables
deep-tissue
imaging
high
spatial
resolution.
In
addition,
can
respond
high-energy
photons,
such
X-rays,
trigger
nonradioactive
radiative
pathways,
making
it
develop
high-sensitivity
X-ray
detectors.
Precise
control
paramagnetic
lanthanide
ions
nanocrystal
lattices
provides
materials
high-performance
magnetic
resonance
medical
diagnostics
research.
Full
consideration
fundamental
will
facilitate
multifunctional
sensitive
probes
improve
diagnostic
therapeutic
outcomes.In
this
Account,
we
categorize
various
lanthanide-activation
strategies
into
three
modes:
excitation,
field
stimulation.
We
introduce
energy
manipulations
upconverting,
downshifting,
persistence
spectral
time
domains
discuss
how
they
be
applied
practices.
assess
general
principles
nanosystems
multiple
modalities
review
current
state-of-the-art
lanthanide-based
theranostic
nanoplatforms,
particular
emphasis
on
conversion
nano-/biointerfacing
emerging
bioapplications.
context,
highlight
recent
advances
controlling
nanoplatforms
single-
multimodal
stimulus-responsive
phototherapy,
optogenetics.
Finally,
future
challenges
exciting
field.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(4), P. 1336 - 1376
Published: Jan. 1, 2022
Bioorthogonal
chemistry
is
a
powerful
tool
to
site-specifically
activate
drugs
in
living
systems.
reactions
between
pair
of
biologically
reactive
groups
can
rapidly
and
specifically
take
place
mild
physiological
milieu
without
perturbing
inherent
biochemical
processes.
Attributed
their
high
selectivity
efficiency,
bioorthogonal
significantly
decrease
background
signals
bioimaging.
Compared
with
metal-catalyzed
click
reactions,
metal-free
are
more
biocompatible
the
metal
catalyst-induced
cytotoxicity.
Although
great
number
chemistry-based
strategies
have
been
reported
for
cancer
theranostics,
comprehensive
review
scarce
highlight
advantages
these
strategies.
In
this
review,
recent
progress
theranostics
guided
by
will
be
depicted
detail.
The
elaborate
design
as
well
tumor
summarized
future
prospects
emerging
field
emphasized.
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(3)
Published: Jan. 20, 2022
Abstract
The
tumor
microenvironment
(TME),
including
intracellular
and
extracellular
microenvironment,
contains
many
biochemical
indicators
(such
as
acidity/alkalinity,
oxygen
content,
enzymatic
activity)
that
are
different
from
the
normal
physiological
environment.
These
abnormal
can
accelerate
heterogeneity
of
tumors,
but
on
other
hand,
they
also
provide
opportunities
for
design
intelligent
drug
delivery
systems
(DDSs).
TME‐responsive
DDSs
have
shown
great
potential
in
reducing
side
effects
chemotherapy
improving
curative
effect
tumors.
In
this
review,
TME
introduced
detail
both
aspects.
view
various
barriers
encountered
during
delivery,
strategy
constructing
is
discussed.
By
summarizing
typical
research
progress,
authors
prospect
development
DDS
future.
