Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: June 3, 2020

Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) good reactive oxygen species (ROS) scavenging ability biocompatibility a promising way for the ROS-related inflammation. Herein we report simple efficient one-step ultrasmall Cu

Language: Английский

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A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: July 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Language: Английский

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Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(35), P. 6939 - 6957

Published: Jan. 1, 2021

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well proposes the current challenges prospects in development nanozymes.

Language: Английский

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Metal–organic framework based nanozymes: promising materials for biochemical analysis

Chemical Communications, Journal Year: 2020, Volume and Issue: 56(77), P. 11338 - 11353

Published: Jan. 1, 2020

Metal–organic frameworks with enzyme-like catalytic features (MOF nanozymes) exhibit great promise in detecting various analytes amplified signal outputs.

Language: Английский

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Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(49)

Published: Oct. 30, 2020

Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to molecular/atomic-level centers, high porosity, large surface area, loading capacity, homogeneous structure, metal–organic frameworks (MOFs) emerged as one the most promising materials engineering Enz-Cats. Here, recent advances design MOF-engineered Enz-Cats, including preparation methods, composite constructions, structural characterizations, biomedical applications, are highlighted commented upon. In particular, performance, selectivities, essential mechanisms, potential structure–property relations these Enz-Cats accelerating reactions discussed. Some applications also breifly proposed. These include, for example, tumor therapies, bacterial disinfection, tissue regeneration, biosensors. Finally, future opportunities challenges emerging research frontiers thoroughly Thereby, pathways perspectives designing state-of-the-art sciences offered.

Language: Английский

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Advances in metal–organic framework-based nanozymes and their applications

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 449, P. 214216 - 214216

Published: Sept. 15, 2021

Language: Английский

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Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Materials Today, Journal Year: 2021, Volume and Issue: 44, P. 211 - 228

Published: Jan. 14, 2021

Language: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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Metal–Organic Frameworks Enhance Biomimetic Cascade Catalysis for Biosensing

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 23, 2021

Abstract Multiple enzymes‐induced biological cascade catalysis guides efficient and selective substrate transformations in vivo. The biomimetic systems, as ingenious strategies for signal transduction amplification, have a wide range of applications biosensing. However, the fragile nature enzymes greatly limits their applications. In this regard, metal–organic frameworks (MOFs) with porous structures, unique nano/microenvironments, good biocompatibility been skillfully used carriers to immobilize shielding them against hash surroundings improving catalytic efficiency. For another, nanomaterials enzyme‐like properties brilliant stabilities (nanozymes), widely applied ameliorate low stability enzymes. Inheriting abovementioned merits MOFs, performances MOFs‐immboilized nanozymes could be significantly enhanced. Furthermore, addition carriers, some MOFs can also serve nanozymes, expanding systems. Herein, recent advances fabrication MOFs‐involving enzymes/nanozymes systems biosensing are highlighted. Integrating diversified output modes, including colorimetry, electrochemistry, fluorescence, chemiluminescence, surface‐enhanced Raman scattering, sensitive detection various targets (including molecules, environmental pollutants, enzyme activities, so on) realized. Finally, challenges opportunities about further constructions reaction briefly put forward.

Language: Английский

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Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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