Emerging materials for hemostasis

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214823 - 214823

Published: Oct. 20, 2022

Language: Английский

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Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(46)

Published: Aug. 4, 2023

Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids, meanwhile, hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS CM/Tetra‐PEG‐NH ) with stable robust adhesion tissue though covalent bonding. The vitro vivo results suggest that optimized formulation exhibits strong adhesive, high burst pressure, enhanced blood clotting ability, as excellent biocompatibility on‐demand removal properties. A significantly improved hemostatic efficacy demonstrated rat liver, spleen, femoral artery injury models compared CM, commercial fibrin glue, Yunnan Baiyao (YB). also halt severe bleeding from pig visceral organs. Overall, proposed has many advantages including good biocompatibility, rapid effective hemostasis, cost, ease use, making it promising hemostat hemorrhage control.

Language: Английский

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Fast Expandable Chitosan‐Fibers Cryogel from Ambient Drying for Noncompressible Bleeding Control and In Situ Tissue Regeneration

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(16)

Published: March 15, 2023

Abstract Hemorrhage control, especially noncompressible wound hemostasis, is a tremendous challenge in military injuries and other traumas worldwide. Here, cryogelation strategy subsequent solvent exchange are developed for the hydrogen bond‐induced self‐assembly of chitosan fibers production fast expandable cryogel. Importantly, ambient drying process facilitates repeatable deformation performance shape‐memory cryogel with response time ≈1.7 s. Due to capillary‐like structure high hydrophilicity, rapid shape recovery accompanied by 41 times water absorption ability. It further demonstrated that beneficial situ tissue regeneration taking advantage biodegradability biocompatibility chitosan. Thus, cryogels prepared this simple benign method should have efficient hemostatic effect on bleeding severe fatal high‐pressure hemorrhage.

Language: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

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Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence toxicity cells, loading therapeutic agents, release active ions during hemostasis process. Therefore, understanding fundamentals tuning these is important design types carriers. While several literature reviews explored role MSNs control, comprehensive studies focusing on general specific applications remain scarce. This review concentrates principles synthesizing silica, MSNs, techniques for drugs methods onto site injury, kinetics models, biocompatibility, toxicity, unique properties MSNs. Furthermore, article examines mechanism action nanomaterial hemostatic agents.

Language: Английский

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Recent advances in materials for hemostatic management

Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(22), P. 7343 - 7378

Published: Jan. 1, 2021

Traumatic hemorrhage can be a fatal event, particularly when large quantities of blood are lost in short period time. Therefore, hemostasis has become crucial part emergency treatment. For small wounds, achieved intrinsically depending on the body's own coagulation mechanism; however, for large-area battlefield and complex materials delivering rapid effective required. In parallel with constant progress science, technology, society, advances hemostatic have also undergone various iterations by integrating new ideas old concepts. There natural synthetic materials, including powders, adhesives, hydrogels, tourniquets, treatment severe external trauma. This review covers differences among currently available comprehensively describes effects different based underlying mechanisms. Finally, solutions current issues related to trauma bleeding discussed, prospects proposed.

Language: Английский

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Hemostatic biomaterials to halt non-compressible hemorrhage

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(37), P. 7239 - 7259

Published: Jan. 1, 2022

Non-compressible hemorrhage is an unmet clinical challenge, which occurs in inaccessible sites the body where compression cannot be applied to stop bleeding. Current treatments reliant on blood transfusion are limited efficacy and complicated by supply (short shelf-life high cost), immunogenicity contamination risks. Alternative strategies based hemostatic biomaterials exert biochemical and/or mechanical cues halt hemorrhage. The hemostats built upon native coagulation cascades, while use efforts This review covers design principles applications of such biomaterials, following overview mechanisms clot mechanics. We present how modulate fibrinolysis, also as absorption, agglutination, adhesion achieve hemostasis. outline challenges immediate opportunities provide comprehensive guidelines for rational biomaterials.

Language: Английский

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Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100468 - 100468

Published: Oct. 18, 2022

Uncontrolled bleeding remains as a leading cause of death in surgical, traumatic, and emergency situations. Management the hemorrhage development hemostatic materials are paramount for patient survival. Owing to their inherent biocompatibility, biodegradability bioactivity, biopolymers such polysaccharides polypeptides have been extensively researched become focus next-generation materials. The construction novel requires in-depth understanding physiological process, fundamental mechanisms, effects material chemistry/physics. Herein, we recapitulated common strategies status biopolymer-based Furthermore, mechanisms various molecular structures (components chemical modifications) summarized from microscopic perspective, design based on them introduced. From macroscopic forms materials, e.g., powder, sponge, hydrogel gauze, is compared, which may provide an enlightenment optimization hemostat design. It has also highlighted current challenges proposed future directions chemistry design, advanced form clinical application.

Language: Английский

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Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)

Published: March 21, 2023

Short designer self-assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide diverse and robust toolbox for surgeons integrate wound microenvironment with much safer stronger hemostatic capacity than conventional materials agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, internal medical bleeding (IMB), respect optimal formulation, dSAP ingenious nanofiber alternatives make bioactive neural scaffold, nasal packing, large coverage gastrointestinal surgery (esophagus, gastric lesion, duodenum, lower digestive tract), epicardiac cell-delivery carrier, transparent matrix barrier, so on. Herein, multiple surgical specialties, dSAP-biomaterial-based nano-hemostats achieve safe, effective, immediate hemostasis, facile healing, potentially reduce risks delayed rebleeding, post-operative or related complications. The biosafety vivo, indications, tissue-sealing quality, feasibility, local usability addressed comprehensively sequentially pursued develop useful techniques better performance. Here, state of art all-round advancements nano-hemostatic approaches provided. Relevant critical insights will inspire exciting investigations on nanotechnology, next-generation biomaterials, promising prospects clinics.

Language: Английский

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Bioactive carbon dots for tissue engineering applications

Smart Materials in Medicine, Journal Year: 2023, Volume and Issue: 5(1), P. 1 - 14

Published: June 25, 2023

Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials with characteristic sizes of less than 10 ​nm. Recently, bioactive CDs have made remarkable achievements in wound healing, bone and cartilage repair, neural regeneration, myocardium regeneration owing to their unique physicochemical properties excellent biocompatibility, which significantly promoted the advancement tissue engineering. Herein, we summarize applications First, briefly introduce characteristics synthesis methods CDs. Subsequently, review engineering, cardiac engineering detail. Finally, discuss challenges prospects

Language: Английский

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