Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(46)

Published: Aug. 4, 2023

Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids, meanwhile, hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS CM/Tetra‐PEG‐NH ) with stable robust adhesion tissue though covalent bonding. The vitro vivo results suggest that optimized formulation exhibits strong adhesive, high burst pressure, enhanced blood clotting ability, as excellent biocompatibility on‐demand removal properties. A significantly improved hemostatic efficacy demonstrated rat liver, spleen, femoral artery injury models compared CM, commercial fibrin glue, Yunnan Baiyao (YB). also halt severe bleeding from pig visceral organs. Overall, proposed has many advantages including good biocompatibility, rapid effective hemostasis, cost, ease use, making it promising hemostat hemorrhage control.

Language: Английский

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Polysaccharides based rapid self-crosslinking and wet tissue adhesive hemostatic powders for effective hemostasis

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 312, P. 120819 - 120819

Published: March 17, 2023

Language: Английский

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Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 26, 2022

Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under impair the function and integrity of hemostatic agents adhesion bioadhesive sealants. Here, we report design performance bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused functional liquids. The can rapidly absorb interfacial fluids such as whole promote clotting, while liquids facilitate bonding, sealing, antibacterial function. Their synergy enables bioadhesives to form on ex vivo human porcine tissues diverse engineered surfaces without need compression, well on-demand instant removal storage stability. We demonstrate significantly improved efficacy biocompatibility rats pigs compared non-structured counterparts commercial products. This work opens new avenues development

Language: Английский

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A Choline Phosphoryl-Conjugated Chitosan/Oxidized Dextran Injectable Self-Healing Hydrogel for Improved Hemostatic Efficacy

Biomacromolecules, Journal Year: 2022, Volume and Issue: 24(2), P. 690 - 703

Published: Dec. 19, 2022

The development of injectable hydrogels with good biocompatibility, self-healing, and superior hemostatic properties is highly desirable in emergency clinical applications. Herein, we report an situ self-healing hydrogel based on choline phosphoryl functionalized chitosan (CS-g-CP) oxidized dextran (ODex). CP groups were hypothesized to accelerate hemostasis by facilitating erythrocyte adhesion aggregation. Our results reveal that the CS-g-CP/ODex exhibit enhanced blood clotting adhesion/aggregation capacities compared those CS/ODex hydrogels. CS-g-CP50/ODex75 presents rapid gelation time, mechanical strength tissue adhesiveness, satisfactory bursting pressure, favorable biocompatibility. ability was significantly improved commercial fibrin sealant rat tail amputation liver/spleen injury models. study highlights positive synergistic effects strongly supports as a promising adhesive for hemorrhage control.

Language: Английский

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Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)

Published: March 21, 2023

Short designer self-assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide diverse and robust toolbox for surgeons integrate wound microenvironment with much safer stronger hemostatic capacity than conventional materials agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, internal medical bleeding (IMB), respect optimal formulation, dSAP ingenious nanofiber alternatives make bioactive neural scaffold, nasal packing, large coverage gastrointestinal surgery (esophagus, gastric lesion, duodenum, lower digestive tract), epicardiac cell-delivery carrier, transparent matrix barrier, so on. Herein, multiple surgical specialties, dSAP-biomaterial-based nano-hemostats achieve safe, effective, immediate hemostasis, facile healing, potentially reduce risks delayed rebleeding, post-operative or related complications. The biosafety vivo, indications, tissue-sealing quality, feasibility, local usability addressed comprehensively sequentially pursued develop useful techniques better performance. Here, state of art all-round advancements nano-hemostatic approaches provided. Relevant critical insights will inspire exciting investigations on nanotechnology, next-generation biomaterials, promising prospects clinics.

Language: Английский

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Applications of injectable hemostatic materials in wound healing: principles, strategies, performance requirements, and future perspectives

Theranostics, Journal Year: 2023, Volume and Issue: 13(13), P. 4615 - 4635

Published: Jan. 1, 2023

Uncontrolled traumatic bleeding can lead to death due excessive blood loss within minutes.Early intervention is crucial save lives, making timely and effective hemostasis a major global challenge.Injectable hemostatic materials (IHMs) have been proposed improve the effectiveness of hemostasis, facilitate wound healing, enhance survival rates in emergency situations.The superior performance IHMs has garnered significant attention.However, there are relatively few comprehensive reviews on IHMs.This paper aims provide review latest research progress recent years.Firstly, physiological process underlying principles analyzed.Subsequently, synthesis strategies for different discussed.The requirements then summarized, including high efficiency, biocompatibility, degradability, manipulability, stability antibacterial ability.Finally, development prospects challenges presented.This serves as necessary systematic summary IHMs, providing valuable reference new high-performance their practical clinical applications.

Language: Английский

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Injectable hemostatic hydrogel adhesive with antioxidant, antibacterial and procoagulant properties for hemorrhage wound management

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 673, P. 395 - 410

Published: June 6, 2024

Language: Английский

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What else should hemostatic materials do beyond hemostasis: A review

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 101008 - 101008

Published: March 2, 2024

Massive blood loss due to injury is the leading cause of prehospital deaths in disasters and emergencies. Hemostatic materials are used realize rapid hemostasis protect patients from death. Researchers have designed developed a variety hemostatic materials. However, addition their effect, must be endowed with additional functions meet practical application requirements different scenarios. Here, strategies for modifications use scenarios listed: effective positioning at site deep narrow wounds stop bleeding, resistance high pressure wound movement maintain formation, easy removal without affecting further treatment after completed, continued function when retained as dressing (such antibacterial, antiadhesion, tissue repair, etc.). The problems encountered progress researchers will discussed this review. We hope provide valuable references design more comprehensive

Language: Английский

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A ZIF-8-encapsulated interpenetrated hydrogel/nanofiber composite patch for chronic wound treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(8), P. 2042 - 2053

Published: Jan. 1, 2024

Designing wound dressings necessitates the crucial considerations of maintaining a moist environment and implementing effective bacterial control. Furthermore, developing three-dimensional framework emulating extracellular matrix (ECM) confers advantages in fostering cellular migration proliferation. Inspired by this, hydrogel/nanofiber composites have been demonstrated as promising materials for dressings. The also overcome disadvantages poor mechanical properties rapid release traditional pure hydrogels. In this study, we constructed calcium alginate hydrogel/polylactic acid nanofiber (CAH/PLANF) composite with an interpenetrated network. Additionally, synthesis zeolitic imidazolate framework-8 (ZIF-8) incorporated into system endowed enhanced photodynamic antibacterial attributes. obtained patch (ZIF-8@CAH/PLANF) exhibited excellent swelling, strong properties, low cytotoxicity, durable effect efficacy higher than 99.99%. Finally, infection healing were investigated

Language: Английский

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Chitosan Hemostatic Dressings: Properties and Surgical Applications

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1770 - 1770

Published: June 22, 2024

Wounds caused by trauma and/or surgery represent a significant challenge in contemporary medical practice, requiring innovative approaches to promote optimal healing and reduce the risk of bleeding complications resulting from it. In this context, chitosan, natural polysaccharide derived chitin, represents an ideal material for study application devices, form dressings, wound management pre- post-operative wounds due its ability induce hemostasis high biocompatibility with biological tissues. The aim work was discuss structural characteristics, properties chitosan-based hemostatic dressings processes or post-surgical approaches.

Language: Английский

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