Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

Aggregate, Journal Year: 2020, Volume and Issue: 1(1), P. 80 - 106

Published: Dec. 1, 2020

Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.

Language: Английский

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Recent advances of AIE light-up probes for photodynamic therapy

Chemical Science, Journal Year: 2021, Volume and Issue: 12(19), P. 6488 - 6506

Published: Jan. 1, 2021

AIE fluorogens provide new opportunities for the development of light-up probes photodynamic therapy.

Language: Английский

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Recent Advances on Host–Guest Material Systems toward Organic Room Temperature Phosphorescence

Small, Journal Year: 2021, Volume and Issue: 18(1)

Published: Nov. 1, 2021

Abstract The design and characterization of purely organic room‐temperature phosphorescent (RTP) materials for optoelectronic applications is currently the focus research in field electronics. Particularly, with merits preparation controllability modulation flexibility, host–guest material systems are encouraging candidates that can prepare high‐performance RTP materials. By regulating interaction between host guest molecules, it effectively control quantum efficiency, luminescent lifetime, color materials, even produce emission stimuli‐responsive features, holding tremendous potential diverse such as encryption anti‐counterfeiting, light‐emitting diodes, sensing, optical recording, etc. Here a roundup rapid achievement construction strategies, molecule systems, diversity outlined. Intrinsic correlations molecular properties survey recent significant advances development divided into three including rigid matrix, exciplex, sensitization presented. Providing an insightful understanding offering promising platform high throughput screening inherent advantages simple preparation, low‐cost, versatile resource, controllably modulated wide range intended.

Language: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Organic photosensitizers for antimicrobial phototherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3324 - 3340

Published: Jan. 1, 2022

This tutorial review highlights the concept and significance of antibacterial phototherapy. Recent developments, advantages, challenges organic photosensitizers in this area are also discussed.

Language: Английский

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Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(38), P. 7909 - 7926

Published: Jan. 1, 2021

Photothermal therapy (PTT) has been widely applied in cancer as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final effect PTT mainly depends on photothermal materials, which can be further considered to determined by conversion efficiency, biocompatibility, stability materials. this review, materials including inorganic organic organic-inorganic composite recent years have summarized terms mechanism, preparation, applications. end, perspectives obstacles their development are overviewed.

Language: Английский

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Photodynamic therapy for hypoxic tumors: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

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Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

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Covalent organic frameworks as multifunctional materials for chemical detection

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(24), P. 13498 - 13558

Published: Jan. 1, 2021

Sensitive and selective detection of chemical biological analytes is critical in various scientific technological fields. As an emerging class multifunctional materials, covalent organic frameworks (COFs) with their unique properties modularity, large surface area, high stability, low density, tunable pore sizes functionalities, which together define programmable properties, show promise advancing detection. This review demonstrates the recent progress where COFs constitute integral component achieved function. highlights how can be harnessed to develop different types systems based on principles chromism, luminescence, electrical transduction, chromatography, spectrometry, others achieve highly sensitive analytes, ranging from gases, volatiles, ions, biomolecules. The key parameters performance for target are summarized, compared, analyzed perspective mechanism structure-property-performance correlations COFs. Conclusions summarize current accomplishments analyze challenges limitations that exist under mechanisms. Perspectives future directions research advance COF-based through innovation novel COF design synthesis, device fabrication, exploration modes also discussed.

Language: Английский

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Near-Infrared-Absorbing B–N Lewis Pair-Functionalized Anthracenes: Electronic Structure Tuning, Conformational Isomerism, and Applications in Photothermal Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(41), P. 18908 - 18917

Published: Oct. 4, 2022

B–N-fused dianthracenylpyrazine derivatives are synthesized to generate new low gap chromophores. Photophysical and electrochemical, crystal packing, theoretical studies have been performed. Two energetically similar conformers identified by density functional theory calculations, showing that the core unit adopts a curved saddle-like shape (x-isomer) or zig-zag conformation (z-isomer). In solid state, z-isomer is prevalent according an X-ray structure of C6F5-substituted derivative (4-Pf), but variable-temperature nuclear magnetic resonance suggest dynamic behavior in solution. B–N fusion results large decrease HOMO–LUMO dramatically lowers LUMO energy compared all-carbon analogues. 4-Pf particular shows significant absorbance at greater than 700 nm while being almost transparent throughout visible region. After encapsulation biodegradable polymer DSPE-mPEG2000, nanoparticles (4-Pf-NPs) exhibit good water solubility, high photostability, excellent photothermal conversion efficiency ∼41.8%. 4-Pf-NPs evaluated both vitro vivo as therapeutic agents. These uncover Lewis pair functionalization PAHs promising strategy toward NIR-absorbing materials for applications.

Language: Английский

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