Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 145, P. 112179 - 112179

Published: Nov. 1, 2021

Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on anti-inflammatory efficacy of AST in various chronic acute disorders, such as neurodegenerative, renal-, hepato-, skin- eye-related diseases, well gastrointestinal disorders. addition, elaborated therapeutic role several pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, JAK-2/STAT-3 mediating its effects. However, additional experimental clinical studies should be performed to corroborate effects protective against inflammatory diseases humans. Nevertheless, review suggests that demonstrated property may suitable candidate for drug design novel technology.

Language: Английский

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Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(10), P. 531 - 531

Published: Sept. 23, 2021

Acute inflammation is a key component of the immune system's response to pathogens, toxic agents, or tissue injury, involving stimulation defense mechanisms aimed removing pathogenic factors and restoring homeostasis. However, uncontrolled acute inflammatory may lead chronic inflammation, which involved in development many diseases, including cancer. Nowadays, need find new potential therapeutic compounds has raised worldwide scientific interest study marine environment. Specifically, microalgae are considered rich sources bioactive molecules, such as carotenoids, natural isoprenoid pigments with important beneficial effects for health due their biological activities. Carotenoids essential nutrients mammals, but they unable synthesize them; instead, dietary intake these required. classified carotenes (hydrocarbon carotenoids), α- β-carotene, xanthophylls (oxygenate derivatives) zeaxanthin, astaxanthin, fucoxanthin, lutein, β-cryptoxanthin, canthaxanthin. This review summarizes present up-to-date knowledge anti-inflammatory anticancer activities microalgal carotenoids both vitro vivo, well latest status human studies use prevention treatment diseases

Language: Английский

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Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 788, P. 147780 - 147780

Published: May 15, 2021

Language: Английский

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Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution liver-microbiota-gut axis in chronic inorganic exposure-triggered biotoxicity chickens based on multi-omics technologies. Forty Hy-Line W-80 laying hens were chronically exposed sodium arsenite with dose-dependent manner (administered drinking water containing 10, 20, or 30 mg/L arsenic, respectively) 42 d, followed transcriptomics, serum non-targeted metabolome, 16S ribosomal RNA gene sequencing accordingly. intervention induced serious chicken liver dysfunction, especially severe fibrosis, simultaneously altered ileal microbiota populations, impaired intestinal barrier, further drove enterogenous lipopolysaccharides translocation via portal vein circulation aggravating damage. Furtherly, injured disturbed bile acids (BAs) homoeostasis through strongly up-regulating BAs synthesis key rate-limiting enzyme CYP7A1, inducing excessive total accumulation, accompanied massive primary BA—chenodeoxycholic acid. Moreover, concentrations secondary BAs—ursodeoxycholic acid lithocholic markedly repressed, which might involve repressed dehydroxylation Ruminococcaceae Lachnospiraceae families. Abnormal metabolism turn promoted injury, ultimately perpetuating pernicious circle chickens. Notably, obvious depletion abundance four profitable microbiota, Christensenellaceae, Ruminococcaceae, Muribaculaceae, Faecalibacterium, correlated tightly this hepato-intestinal process Our demonstrates that exposure evokes disruption establishes scientific basis evaluating risk environmental pollutant

Language: Английский

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Toxicological effects of deltamethrin on quail cerebrum: Weakened antioxidant defense and enhanced apoptosis

Environmental Pollution, Journal Year: 2021, Volume and Issue: 286, P. 117319 - 117319

Published: May 6, 2021

Language: Английский

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Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 207, P. 111501 - 111501

Published: Nov. 3, 2020

Deltamethrin (DLM) is widely used in agriculture and the prevention of human insect-borne diseases. However, molecular mechanism DLM induced liver injury remains unclear to date. This study investigated potential that fibrosis quails. Japanese quails received resveratrol (500 mg/kg) daily with or without (45 exposure for 12 weeks. Histopathology, transmission electron microscopy, biochemical indexes, TUNEL, quantitative real-time PCR, western blot analysis were performed. hepatic steatosis, oxidative stress, inflammation, apoptosis. Most importantly, Nrf2/TGF-β1/Smad3 signaling pathway played an important role on DLM-induced Interestingly, addition resveratrol, Nrf2 activator, alleviates stress inflammation response by activating Nrf2, thereby inhibits Collectively, these findings demonstrate chronic induces via expression inhibition apoptosis, then results activation NF-κB/TNF-α TGF-β1/Smad3 pathway.

Language: Английский

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Hexavalent chromium induced heart dysfunction via Sesn2-mediated impairment of mitochondrial function and energy supply

Chemosphere, Journal Year: 2020, Volume and Issue: 264, P. 128547 - 128547

Published: Oct. 7, 2020

Language: Английский

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The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 35, P. 129 - 140

Published: April 8, 2021

Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates structure function most proteins in variety ways. However, hepatotoxicity Cr(VI) whether it is related deacetylation remains largely unknown.We aimed explore link between silent information regulator two ortholog 1 (Sirt1) induced by exposure, better clarify biological mechanism liver injury Cr(VI).We established model K2Cr2O7 injecting rats intraperitoneally for 35 days continuously adding resveratrol (Res) further hepatotoxicity.The results revealed that inflammatory response apoptosis hepatocytes. Furthermore, reduced Sirt1 expression inhibited downstream key transcription factors, including nuclear factor erythroid 2-related 2 (Nrf2), Forkhead box O3 (FOXO3), factor-kappa B (NF-κB). Conversely, when Res was administered as an activator Sirt1, enhanced, were significantly alleviated.In summary, this work firstly demonstrates induces rat inhibiting which positive significance protecting natural environment health from chronic Cr poisoning.

Language: Английский

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Harmful Effects of Inorganic Mercury Exposure on Kidney Cells: Mitochondrial Dynamics Disorder and Excessive Oxidative Stress

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(4), P. 1591 - 1597

Published: May 31, 2021

Language: Английский

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The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis

Chemosphere, Journal Year: 2022, Volume and Issue: 300, P. 134479 - 134479

Published: March 31, 2022

Language: Английский

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