Overview of the Importance of Biotics in Gut Barrier Integrity

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2896 - 2896

Published: March 7, 2022

Increased gut permeability is suggested to be involved in the pathogenesis of a growing number disorders. The altered intestinal barrier and subsequent translocation bacteria or bacterial products into internal milieu human body induce inflammatory state. Gut microbiota maintains epithelium integrity. Since dysbiosis contributes increased permeability, interventions that change correct are also restore function. In this review, current knowledge on role biotics (probiotics, prebiotics, synbiotics postbiotics) maintaining function summarized. potential outcome results from vitro animal studies presented, need for further well-designed randomized clinical trials highlighted. Moreover, we indicate understand mechanisms by which regulate barrier. This review concluded with future direction requirement involving

Language: Английский

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Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 565 - 587

Published: Nov. 18, 2023

Language: Английский

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Role of Bifidobacterium in Modulating the Intestinal Epithelial Tight Junction Barrier: Current Knowledge and Perspectives

Current Developments in Nutrition, Journal Year: 2023, Volume and Issue: 7(12), P. 102026 - 102026

Published: Oct. 30, 2023

The intestinal tight junction (TJ) barrier is a crucial defense mechanism that prevents the passage of content into wall, tissue, and systemic circulation. A compromised TJ has been identified as significant factor in inflammatory bowel disease (IBD), necrotizing enterocolitis, other gut-related conditions. Recent studies have revealed importance probiotic bacterial strains Bifidobacterium protecting against inflammation IBD pathogenesis via regulation function. Numerous species found to regulate proteins signaling pathways responsible for maintaining integrity permeability. In this review, we provide summary recent highlight regulatory role strain effect on barrier. We also discuss intracellular mechanisms involved modulation potential therapeutic efficacy targeting function inflammation.

Language: Английский

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Advances and challenges in interaction between heteroglycans and Bifidobacterium: Utilization strategies, intestinal health and future perspectives

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 134, P. 112 - 122

Published: March 1, 2023

Language: Английский

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Probiotics for the treatment of depression and its comorbidities: A systemic review

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 17, 2023

Depression is one of the most common psychiatric conditions, characterized by significant and persistent depressed mood diminished interest, often coexists with various comorbidities. The underlying mechanism depression remain elusive, evidenced lack an appreciate therapy. Recent abundant clinical trials animal studies support new notion that gut microbiota has emerged as a novel actor in pathophysiology depression, which partakes bidirectional communication between brain through neuroendocrine, nervous, immune signaling pathways, collectively known microbiota-gut-brain (MGB) axis. Alterations can trigger changes neurotransmitters, neuroinflammation, behaviors. With transition human microbiome research from studying associations to investigating mechanistic causality, MGB axis therapeutic target its These insights have fueled idea targeting on may open windows for efficient treatment Probiotics, live beneficial microorganisms, be used modulate dysbiosis into eubiosis modify occurrence development In present review, we summarize recent findings regarding discuss potential effects probiotics

Language: Английский

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Effects of Lonicerae flos and Turmeric extracts on growth performance and intestinal health of yellow-feathered broilers

Poultry Science, Journal Year: 2024, Volume and Issue: 103(4), P. 103488 - 103488

Published: Jan. 23, 2024

This experiment aimed to investigate the effect of Lonicerae flos and Turmeric extracts (LTE) added diets on growth performance intestinal health broilers. A total 720 healthy 21-day-old yellow-feathered broilers were randomly divided into 3 treatment groups, with 6 replicates 40 per replicate. These dietary treatments included a basal diet + 0 g/t LTE (CON), 300 (LTE300), 500 (LTE500). The results showed that supplementation linearly increased (P < 0.05) average daily gain (d 21-38) feed intake 21-60). At d 60, LTE300 had highest serum antioxidant capacity superoxide dismutase 0.05), LTE500 lowest malondialdehyde level among three groups. Moreover, compared CON, significantly reduced endotoxin 38 60) diamine oxidase activity 38); levels in serum. groups ileal ratio villus height crypt depth immunoglobulin G. Furthermore, also improved epithelial barrier by up-regulated mRNA expression Claudin-1, Occludin zonula occludens-1, decreased interleukin-2, interleukin-8, tumor necrosis factor-α, nuclear factor κB, myeloid differentiation 88 toll-like receptor 4. Compared 16S rRNA sequencing analysis better microbial diversity composition ileum, Bacillus Lactobacillus_agilis enriched LTE300. PICRUSt was four pathway pathways at KEGG 2. In conclusion, enhancing capacity, immune function, regulating flora

Language: Английский

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Probiotics: Symbiotic Relationship with the Animal Host

Animals, Journal Year: 2022, Volume and Issue: 12(6), P. 719 - 719

Published: March 12, 2022

Antibiotic growth-promoters in animal feeding are known to generate bacterial resistance on commercial farms and have proven deleterious effects human health. This review addresses the of probiotics their symbiotic relationship with host as a viable alternative for producing healthy meat, eggs, milk at present future. Probiotics can tolerate conditions gastrointestinal tract, such gastric acid, pH bile salts, exert beneficial host. They (probiotics) may also effect productivity, health wellbeing different parameters performance. stimulate native microbiota (microbes that place origin) production short-chain fatty acids, antimicrobial, hypocholesterolemic immunomodulatory effects, resulting better intestinal health, nutrient absorption capacity productive responses ruminant non-ruminant animals. These specific each microbial strain; therefore, isolation identification microorganisms, well vitro vivo testing categories farm animals, will guarantee efficacy, replicability sustainability current systems.

Language: Английский

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Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 594 - 594

Published: Jan. 6, 2022

Intestinal homeostasis is a dynamic balance involving the interaction between host intestinal mucosa, immune barrier, microecology, nutrients, and metabolites. Once out of balance, it will increase risk diseases also closely associated with some systemic diseases. Probiotics (Escherichia coli Nissle 1917, Akkermansia muciniphila, Clostridium butyricum, lactic acid bacteria Bifidobacterium spp.), maintaining gut through direct intestine, can exist as specific agent to prevent, alleviate, or cure intestinal-related With genetic engineering technology advancing, probiotics show targeted therapeutic properties. The aims this review are summarize roles potential native engineered in oncology, inflammatory bowel disease, obesity, discussing applications these probiotics.

Language: Английский

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Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 14, 2022

Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by and rapid onset as well high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), earliest accompanied dysfunction, common cause death patients following SAP onset. The exact pathogenesis ALI during SAP, however, remains unclear. In recent years, advances microbiota-gut-lung axis have led a better understanding SAP-associated (PALI). addition, bidirectional communications between intestinal microbes are becoming more apparent. This paper aims review mechanisms an imbalanced microbiota contributing development PALI, mediated disruption physical, chemical, immune barriers intestine, promotes bacterial translocation, results activation abnormal responses severe pancreatitis. pathogen-associated molecular patterns (PAMPs) immunol occurrence PALI via binding with pattern recognition receptors (PRRs) through focused this study. Moreover, potential therapeutic strategies for alleviating regulating composition or function discussed review. aim study provide new ideas tools patients.

Language: Английский

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Lactobacillus rhamnosus CY12 Enhances Intestinal Barrier Function by Regulating Tight Junction Protein Expression, Oxidative Stress, and Inflammation Response in Lipopolysaccharide-Induced Caco-2 Cells

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11162 - 11162

Published: Sept. 22, 2022

The intestinal barrier is vital for preventing inflammatory bowel disease (IBD). objectives of this study were to assess whether the Lactobacillus rhamnosus CY12 could alleviate oxidative stress, inflammation, and disruption tight junction (TJ) functions induced by lipopolysaccharide (LPS), therefore explore potential underlying molecular mechanisms. Our results showed that LPS-induced Cancer coli-2 (Caco-2) cells significantly increased levels reactive oxygen species (ROS), lactate dehydrogenase, cytokines interleukin-1β, interleukin-6, interleukin-8, tumor necrosis factor-α (IL-1β, IL-6, IL-8, TNF-α), cell apoptosis rate while decreasing TJ proteins occludin, zonula occludens-1 (ZO-1), claudin antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase(CAT, SOD, GSH-Px) (p < 0.05). However, relieve cytotoxicity, apoptosis, pro-inflammatory cytokine expressions, also inhibit Toll-like receptor 4/nuclear factor kappa-B(TLR4/NF-κB) signaling pathway. Furthermore, gene expression well mRNA protein expressions proteins, was improved. Particularly, concentration 108 cfu/mL prevented injury LPS in Caco-2 These findings support a application probiotic prevent treat dysfunction.

Language: Английский

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