Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 9, 2025

The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as key mediator. However, it remains unclear whether specific microbial factors regulate metabolism to influence 5-HT production regulation. In this study, we analyzed 110 athletes undergoing closed training found that fecal lactate levels were significantly associated with indicators. We observed significant negative correlation between Akkermansia abundance athletes. Co-supplementation muciniphila (A. muciniphila) modulated by increasing enzyme TPH1 reducing IDO1, thus shifting kynurenine (Kyn) 5-HT. addition, enhanced the propionate capacity of A. muciniphila, potentially contributing reduction mice. Taken together, these findings suggest enteric collaboratively restore imbalance leading increased activity alleviating phenotypes. This study highlights intricate interplay metabolites regulation, offering potential avenues for microbiota-targeted therapeutic strategies anxiety.

Language: Английский

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Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2132 - 2132

Published: Oct. 28, 2022

Depression and anxiety are severe public health problems have attracted more attention from researchers of food science nutrition. Dietary natural products nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, dietary fiber, could play a vital role in the prevention management these diseases. The potential mechanisms action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, regulating levels monoamine neurotransmitters. In this narrative review, we summarize most recent advancements regarding effects nutrients on depression anxiety, their underlying discussed. We hope that paper can provide better understanding anti-depressive anxiolytic products, it is also helpful for developing functional food, supplements, or auxiliary agents

Language: Английский

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The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2013 - 2013

Published: Feb. 11, 2022

Compelling evidence is building for the involvement of complex, bidirectional communication axis between gastrointestinal tract and brain in neuropsychiatric disorders such as depression. With depression projected to be number one health concern by 2030 its pathophysiology yet fully elucidated, a comprehensive understanding interactions environmental factors, stress diet, with neurobiology needed. In this review, latest research on effects connections gut across most widely used animal models summarised, followed comparisons diversity composition microbiota possible implications gut–brain impact dietary changes these. The was consistently altered investigated, although differences each studies existed. Chronic stressors appeared have negative both health, while supplementation prebiotics and/or probiotics show promise alleviating pathophysiology.

Language: Английский

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Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 7, 2022

Increasing evidence indicated that probiotics can be effective in improving behaviors similar to depression and anxiety disorders. However, the underlying mechanisms remain unclear, as is effects of single vs. combined on anxiety. This study aimed determine whether could attenuate depressive-like anxiety-like behavior induced by chronic unpredictable mild stress (CUMS) its potential mechanisms. Rats underwent CUMS treatment then administered Lactobacillus rhamnosus HN001 (HN001) or Bifidobacterium animalis subsp. lactis HN019 (HN019), alone combination. Levels neurotransmitters, inflammatory factors, gut microbiota were measured. (or) improved rats, including increased moving distance exploratory (p < 0.05). In addition, altered structure was amended and/or intervention also remarkably normalized levels 5-HT, DA, NE, HVA, DOPAC, HIAA, TNF-α, IL-6, IL-18 IL-1β rats Furthermore, decreasing inflammation (Chao1 index ACE index, p 0.05) superior probiotics. Moreover, spearman analysis showed a certain correlation between different microbiota, such Firmicutes, Bacteroidetes, Verrucomicrobias, Proteobacterias Actinobacterias, neurotransmitters. These findings suggested depressive alleviated combination probiotics, which possibly associated with alterations composition neurotransmitters decreased factors.

Language: Английский

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Tebuconazole mediates cognitive impairment via the microbe-gut-brain axis (MGBA) in mice

Environment International, Journal Year: 2023, Volume and Issue: 173, P. 107821 - 107821

Published: Feb. 13, 2023

Tebuconazole, one of the most widely used triazole fungicides, is reported to potentially pose a risk inducing neurological disorders in human beings. Considering increasing exposure, whether it could influence cognitive function remains be elucidated. Herein, we mouse model evaluate potential risks and possible mechanisms from continuous edible application tebuconazole at low concentrations. Our study revealed that deteriorated spatial learning memory downregulated expression glutamate receptor subunits. Importantly, metagenomic analysis indicated not only led significant shifts composition diversity gut microbiota but also changed intestinal homeostasis. Specifically, after circulated bloodstream largely entered gut-brain axis for disruption, including disturbing Firmicutes/Bacteroidetes ratio, interrelated neurotransmitters systemic immune factors. Moreover, pretreatment with probiotics improved factor restored deterioration synaptic memory. The current provides novel insights concerning perturbations microbiome its functions as new mechanism by which exposes function-related health.

Language: Английский

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Whole-Genome Sequence of Lactococcus lactis Subsp. lactis LL16 Confirms Safety, Probiotic Potential, and Reveals Functional Traits

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 1034 - 1034

Published: April 15, 2023

Safety is the most important criteria of any substance or microorganism applied in food industry. The whole-genome sequencing (WGS) an indigenous dairy isolate LL16 confirmed it to be Lactococcus lactis subsp. with genome size 2,589,406 bp, 35.4% GC content, 246 subsystems, and 1 plasmid (repUS4). Nextera XT library preparation kit was used generate DNA libraries, carried out on Illumina MiSeq platform. In silico analysis L. strain revealed non-pathogenicity absence genes involved transferable antimicrobial resistances, virulence, formation biogenic amines. One region identified as type III polyketide synthases (T3PKS) produce putative bacteriocins lactococcin B, enterolysin A. probiotic functional potential investigated by presence adhesion colonization host's intestines tolerance acid bile, production enzymes, amino acids, B-group vitamins. Genes encoding neurotransmitters serotonin gamma-aminobutyric (GABA) were detected; however, able only GABA during milk fermentation. These findings demonstrate a variety positive features that support use sector GABA-producing properties.

Language: Английский

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Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114525 - 114525

Published: March 13, 2023

Major depression disorder is more common among adolescents and a primary reason for suicide in adolescents. Some antidepressants are ineffective may possess side effects. Therefore, developing an adolescent antidepressant the need of hour. We designed stress model male mice induced by chronic unpredictable (CUS). The were treated using Tongxieyaofang neutral polysaccharide (TXYF-NP), acidic (TXYF-AP), TXYF-AP + TXYF-NP fructooligosaccharide galactooligosaccharides to determine their body weight, behavior, serum hormone levels. RT-qPCR was used detect gene expression Crhr1, Nr3c1, Nr3c2 hypothalamus hippocampus glutamic acid γ-aminobutyric acid-related receptors hippocampus. RT-qPCR, Western blot, ELISA detected tryptophan metabolism colon, serum, 16s rDNA helped sequence colon microflora, non-targeted metabolomics enabled collection metabolic profiles microflora. In mice, CUS depression-like hypothalamic-pituitary-adrenal axis hyperactivity, hippocampal tissue damage, abnormal its related receptors, dysregulation metabolism. revealed that led microflora bile abnormality. could improve bacterial community upregulating relative abundance Lactobacillus gasseri, Lachnospiraceae bacterium 28-4, Bacteroides Ruminococcaceae UCG-014 while preventing CUS-induced changes. TXYF-P can inhibit behavior due regulating colonic restoring disorder. Thus, based on different comparisons, possessed best effect.

Language: Английский

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Therapeutic modulation of the kynurenine pathway in severe mental illness and comorbidities: A potential role for serotonergic psychedelics

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 134, P. 111058 - 111058

Published: June 15, 2024

Mounting evidence points towards a crucial role of the kynurenine pathway (KP) in altered gut-brain axis (GBA) balance severe mental illness (SMI, namely depression, bipolar disorder, and schizophrenia) cardiometabolic comorbidities. Preliminary shows that serotonergic psychedelics their analogues may hold therapeutic potential addressing KP dysregulated GBA SMI In fact, aside from effects on mood, elicit improvement preclinical models obesity, metabolic syndrome, vascular inflammation, which are highly comorbid with SMI. Here, we review literature modulation comorbidities, application to address brain systemic dysfunction underlying Psychedelics might therapeutically modulate comorbidities either directly, via altering by influencing rate-limiting enzymes affecting levels available tryptophan, or indirectly, gut microbiome, metabolome, metabolism, immune system. Despite promising preliminary evidence, mechanisms outcomes remain largely unknown require further investigation. Several concerns discussed surrounding side this approach specific cohorts individuals

Language: Английский

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Psychobiotics for Mitigation of Neuro‐Degenerative Diseases: Recent Advancements

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 68(13)

Published: Sept. 15, 2023

Abstract Ageing is inevitable and poses a universal challenge for all living organisms, including humans. The human body experiences rapid cell division metabolism until approximately 25 years of age, after which the accumulation metabolic by‐products cellular damage leads to age‐related diseases. Neurodegenerative diseases are concern due their irreversible nature, lack effective treatment, impact on society economy. Researchers interested in finding drugs that can effectively alleviate ageing without side‐effects. Psychobiotics novel class probiotic organisms prebiotic interventions confer mental health benefits host when taken appropriately. Psychobiotic strains affect functions related central nervous system (CNS) behaviors mediated by Gut‐Brain‐Axis (GBA) through various pathways. There an increasing interest researchers these microbial‐based psychopharmaceuticals. have been reported reduce neuronal ageing, inflammation, oxidative stress, cortisol levels; increase synaptic plasticity levels neurotransmitters antioxidants. present review focuses manifestation elderly neurodegenerative disorders, particularly Alzheimer's disease (AD), Parkinson's (PD), depression, current status potential alleviation psychobiotic interventions, highlighting possible mechanisms action.

Language: Английский

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Lactate: a prospective target for therapeutic intervention in psychiatric disease

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(7), P. 1473 - 1479

Published: Nov. 8, 2023

Abstract Although antipsychotics that act via monoaminergic neurotransmitter modulation have considerable therapeutic effect, they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorders. This may be attributed to the limited range of neurotransmitters are regulated by psychotropic drugs. Recent findings indicate need for investigation medications target less-studied neurotransmitters. Among these candidate neurotransmitters, lactate is developing being a waste metabolite glial-neuronal signaling molecule recent years. Previous studies suggested cerebral levels change considerably numerous illnesses; animal experiments also shown supply exogenous exerts an antidepressant effect. In this review, we described how targeting newer offer promise diseases; summarized advances use (and its corresponding pathways) as molecule. addition, alterations brain depression, anxiety, bipolar disorder, and schizophrenia indicated challenges overcome before can used psychopharmacology.

Language: Английский

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