Maximum Emission Peak Over 1500 nm of Organic Assembly for Blood–Brain Barrier‐Crossing NIR‐IIb Phototheranostics of Orthotopic Glioblastoma DOI
Feng Zhao, Xinming Zhang, Fang Bai

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(22)

Published: March 9, 2023

The development of blood-brain barrier (BBB)-crossing phototheranostic agents in second near-infrared window (NIR-II), especially the range 1500-1700 nm (NIR-IIb), affords great opportunities for glioblastoma (GBM) management. Herein, an organic assembly (denoted as LET-12) with maximum absorption peak at 1400 and emission 1512 trailing over 1700 through self-assembly small molecule IR-1064 is designed subsequently decorated choline acetylcholine analogs. LET-12 can effectively cross BBB brain's choline-like receptors-mediated transcytosis accumulated tumor tissues, thus achieving fluorescence/photoacoustic (FL/PA) duplex imaging orthotopic GBM ≈3.0 mm depth a superior tumor-to-normal tissue signal ratio (20.93 ± 0.59 FL 32.63 1.16 PA imaging, respectively). Owing to its good photothermal conversion ability, also serve agent, obvious repression murine model after once treatment. findings indicate that holds potential BBB-crossing NIR-IIb phototheranostics GBM. This strategy molecules opens new avenue construction phototheranostics.

Language: Английский

NIR-II light in clinical oncology: opportunities and challenges DOI
Zeyu Zhang, Yang Du, Xiaojing Shi

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

Citations

91
Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy DOI
Xiao‐Yun Ran, Ping Chen,

Yan‐Zhao Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(12)

Published: Jan. 11, 2023

Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis therapeutic meet the demands of precision medicine. The information effect are directly determined by fluorescence imaging ability photothermal conversion efficiency (PCE) phototheranostic agents. Hence, how balance competitive radiative nonradiative processes agents is key factor evaluate effect. Herein, molecules named ICRs with high photostaibility rationally designed, exhibiting emission in second near-infrared window (NIR-II, 1000-1700 nm) PCE, which related strong donor-acceptor (D-A) interaction reorganization energy Noteworthily, ICR-Qu stronger D-A large-sized conjugated unit encapsulated nanoparticles exhibits PCE (81.1%). In addition, ICR-QuNPs used (FLI), photoacoustic (PAI), (PTI) guide deep-tissue photonic hyperthermia, achieving removal inhibition breast cancer. Furthermore, combined α-PD-1, show huge potential be facile efficient tool photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based agent, but also sheds light on exploration versatile organic future practical applications.

Language: Английский

Citations

76
Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region DOI
Yang Yang,

Qunying Jiang,

Fan Zhang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

Citations

73
Sulfone-Functionalized Chichibabin’s Hydrocarbons: Stable Diradicaloids with Symmetry Breaking Charge Transfer Contributing to NIR Emission beyond 900 nm DOI

Zhibiao Zhou,

Kun Yang, Long He

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(10), P. 6763 - 6772

Published: Feb. 28, 2024

While monoradical emitters have emerged as a new route toward efficient organic light-emitting diodes, the luminescence property of diradicaloids is still scarcely explored. Herein, by devising novel radical–radical coupling-based synthetic approach, we report class sulfone-functionalized Chichibabin's hydrocarbon derivatives, SD-1–3, featuring varied substituent patterns and moderate to high diradical characters 0.44–0.70, highly stable with rarely seen NIR emission beyond 900 nm. Via comprehensive experimental theoretical investigations, reveal that optoelectronic magnetic properties these materials are significantly tuned variations substitutions (H/CF3/OMe) on molecular skeletons. More importantly, quantum chemical computations indicate embedding sulfone groups has contributed breaking their quasi-C2 symmetry diradicaloid molecules results in an excited-state charge transfer character. Therefore, remarkably deep emissive wavelength up 998 nm, together large Stokes shift (∼386 nm), achieved for CF3-based SD-2 molecule tetrahydrofuran. To best our knowledge, such luminescent represented longest wavelengths among currently reported fluorescent radicals. Overall, work not only establishes approach hydrocarbons but also paves way designing open-shell both fundamental understanding feasible control properties.

Language: Английский

Citations

28
Small molecular cyanine dyes for phototheranostics DOI

Jiuhui Zhang,

Wenjun Wang, Jinjun Shao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986

Published: June 2, 2024

Language: Английский

Citations

26
Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics DOI
Yingpeng Wan, Weilong Chen,

Ying Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Language: Английский

Citations

25
Transition metal-based nanozymes: Classification, catalytic mechanisms and emerging biomedical applications DOI
Dandan Zhang, Qing Chen,

Qunxiang Ren

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215771 - 215771

Published: March 17, 2024

Language: Английский

Citations

24
NIR‐II Excitable Semiconducting Polymers with AIE Characteristics for Fluorescence‐Photoacoustic Imaging‐Guided Synergistic Phototherapy DOI
Jiangao Li, Zhijun Zhang, Shanshan Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: March 22, 2024

Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar configuration commonly‐used electrophilic acceptor moieties. Herein, an ingenious dimerization‐based distortion strategy proposed current work by taking advantage sterically encumbered acceptors structure for successful construction AIE‐active SPs. Through further finely adjusting molecular donor–acceptor interaction strength, obtained named SP3 bearing highest intramolecular charge transfer effect presented NIR‐II aggregation‐induced fluorescence emission, good reactive oxygen species production ability, superior photothermal conversion performance. Accordingly, selected fabricate nanoparticles successfully applied laser‐triggered fluorescence‐photoacoustic imaging‐guided photodynamic‐photothermal therapy tumors. This study represents first excitable SP, offers a new perspective on designing advanced efficient treatment malignant tumor.

Language: Английский

Citations

23
Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo DOI
Tuanwei Li, Yejun Zhang, Feng Wu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics complex biological systems due to its advantages of less background interference, high tissue penetration depth, contrast, and sensitivity. However, traditional NIR‐II imaging, which is characterized by “always on” or “turn mode, lacks ability quantitative detection, leading low reproducibility reliability during bio‐detection. In ratiometric can realize reliable analysis detection vivo providing reference signals correction, generating new opportunities prospects bioimaging biosensing. this review, current design strategies sensing mechanisms probes biosensing applications are systematically summarized. Further, challenges, future perspectives designing also discussed. It hoped that review provide effective guidance promote adoption vivo.

Language: Английский

Citations

20
The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer DOI
Caifa You,

Leyuan Tian,

Jun Zhu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(2), P. 2010 - 2020

Published: Jan. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Language: Английский

Citations

4