Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110800 - 110800
Published: Dec. 1, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)
Published: June 5, 2024
Although self-assembly has emerged as an effective tool for fabricating biomaterials, achieving precise control over the morphologies and functionalities of resultant assemblies remains ongoing challenge. Inspired by copper peptide naturally present in human plasma, this study, we designed a synthetic precursor, FcGH. FcGH can self-assemble via two distinct pathways: spontaneous Cu
Language: Английский
Citations
6
Nano Research, Journal Year: 2024, Volume and Issue: 17(7), P. 6332 - 6341
Published: March 13, 2024
Language: Английский
Citations
4
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102313 - 102313
Published: May 16, 2024
Language: Английский
Citations
4
Nano Letters, Journal Year: 2024, Volume and Issue: 24(24), P. 7397 - 7407
Published: June 5, 2024
Cancer immunotherapies based on cytotoxic CD8+ T lymphocytes (CTLs) are highly promising for cancer treatment. The specific interaction between T-cell receptors and peptide-MHC-I complexes (pMHC-I) cell membranes critically determines their therapeutic outcomes. However, the lack of appropriate endogenous antigens MHC-I presentation disables tumor recognition by CTLs. By devising three antigen-loaded self-assembling peptides pY-K(Ag)-ERGD, pY-K(Ag)-E, Y-K(Ag)-ERGD to noncovalently generate light-activatable supramolecular at sites in different manners, we report pY-K(Ag)-ERGD as a candidate endow cells with pMHC-I targets demand. Specifically, first generates low-antigenic membranes, successive light pulse allows antigen payloads efficiently release from scaffold, directly producing antigenic pMHC-I. Intravenous administration enables light-controlled inhibition when combined adoptively transferred antigen-specific Our strategy is feasible broadening repertoires advancing precision-controlled immunotherapies.
Language: Английский
Citations
4
ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19038 - 19053
Published: July 9, 2024
Surgical intervention is the most common first-line treatment for severe traumatic brain injuries (TBIs) associated with high intracranial pressure, while complexity of these surgical procedures often results in complications. Surgeons struggle to comprehensively evaluate TBI status, making it difficult select optimal strategy. Here, we introduce a fluorescence imaging-based technology that uses high-quality silver indium selenide-based quantum dots (QDs) integrated diagnosis and guidance. These engineered, poly(ethylene glycol)-capped QDs emit near-infrared region, are resistant phagocytosis, importantly, ultrastable after epitaxial growth an aluminum-doped zinc sulfide shell aqueous phase renders long-term light irradiation complex physiological environments. We found intravenous injection enabled both precise mouse model and, more comprehensive evaluation status before, during, operation distinguish from superficial hemorrhages, provide real-time monitoring secondary hemorrhage, guide decision on evacuation hematomas. This QD-based diagnostic system could ultimately complement existing clinical tools treating TBI, which may help surgeons improve patient outcomes avoid unnecessary procedures.
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
The self-assembly of molecules into highly ordered architectures is a ubiquitous and natural process, wherein spontaneously organize large structures to perform diverse functions. Drawing inspiration from the formation nanostructures, cell-mediated has been developed create functional assemblies both inside outside living cells. These techniques have employed regulate cellular world by leveraging dynamic intracellular extracellular microenvironment. This review highlights recent advances future trends in self-assembly, ranging their cytocompatible monomer designs, synthetic strategies, morphological control applications. assembly behaviors are also discussed based on dimensionality self-assembled morphologies zero three dimensions. Finally, this explores its promising potential for biomedical applications, clarifying relationship between initial regulation therapeutic effects subsequent artificial assemblies. Through rationally designing molecular precisely controlling morphologies, cell mediated would provide an innovative platform executing biological
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 29, 2025
The fabrications of circularly polarized luminescent (CPL) material are mainly based on the chemical and physical strategies. Controlled biosynthesis CPL-active materials is beset with difficulties due to lack bioactive precursors bio-reactors. Enlighted by microbe-assisted asymmetric biosynthesis, herein, we show in situ bacterial fermentation Komagataeibacter sucrofermentants fabricate a series cellulosic biofilms CPL green, orange, red, near-infrared colors. This process can trigger emission for CPL-silent glycosylated luminophores amplify glum weak up 10−2 scale. To confirm glycosidic bonds formation during copolymerization process, develop an assay utilizing cellulase-catalyzed biodegradation BC hybrids. More importantly, achieve information encryption Fe3+ dual-channel detection hybrid biofilms. Therefore, this study not only provides another vision preparation but also broadens application fabrication mostly rely Here, authors demonstrate multi-coloured enhanced CPL.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Hierarchical structures with enhanced performances are of growing importance in many fields, but their preparation suffers from tedious and multistep procedures. There remain challenges to transfer magnify the molecular functions hierarchical pursue more unique applications. Herein, a facile one‐step approach for fabrication assembling amphiphilic copolymers, poly(ethylene glycol)‐ block ‐poly(6‐(4‐(4‐pyridyazo)phenoxy)hexyl methacrylate) (PEG‐ b ‐PAzoPy) controlled morphologies functions, is reported. Various including three‐dimensional raspberry‐like assemblies, worm networks (WNs), large compound vesicles obtained through heating‐cooling‐aging process THF/ethanol. The fluorescence detection p ‐nitrophenol at ultralow concentrations (10 −12 m ) realized by formation nonfluorescent nitrophenol‐WNs complexes, taking advantage high surface area cavities WNs. Furthermore, highly efficient nanofiltration composite membrane constructed WNs on commercial polypropylene membrane. More interestingly, using simple 2H,2H,3H,3H‐perfluoroundecanoic acid as H‐bond donor PEG‐ ‐PAzoPy acceptor, they can form complexes further assemble into nanowires ordered liquid crystalline stripes. This study not only offers strategy design also facilitates application advanced materials various fields.
Language: Английский
Citations
0
Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
ConspectusEmulating the structural features or functions of natural systems has been demonstrated as a state-of-the-art strategy to create artificial functional materials. Inspired by assembly and bioactivity proteins, self-assembly peptides into nanostructures represents promising approach for creating biomaterials. Conventional assembled peptide biomaterials are typically formulated in solution delivered pathological sites implementing theranostic objectives. However, this translocation entails switch from formulation conditions physiological environment raises concerns about material performance. In addition, precise efficient accumulation administered at target remains significant challenge, leading potential biosafety issues associated with off-target effects. These limitations significantly hinder progress advanced To address these concerns, past few years have witnessed development situ living new endeavor optimizing biomaterial performance benefiting advances stimuli-responsive reactions regulating noncovalent interactions. refers processes via sites. Due advantages precisely forming well-defined lesions, situ-formed assemblies integrated interesting next-generation biomedical agents.Despite great developing agents, research area still suffers limited toolkit operating under complicated conditions. Considering amino acids being incorporated backbones modified units, an acid is concern. Therefore, our laboratory intensively engaged designing discovering noncanonical (ncAAs) expand manipulating various biological Thus far, we synthesized containing ncAAs 4-aminoproline, 2-nitroimidazole alanine, Se-methionine, sulfated tyrosine, glycosylated serine, which allow us develop acid-responsive, redox-responsive, enzyme-responsive systems. Based on ncAAs, established complex self-sorting assembly, self-amplified dissipative cells optimize peptides. The resulting exhibit morphological adaptability microenvironment, contributes overcoming delivery barriers improvement targeting accumulation. utilizing developed toolkit, further created supramolecular PROTACs, antagonists, probes cancer treatment diagnosis highlight implications usage. Account, summarize journey emphasis mechanism Eventually, also provide forward conceiving prospects challenges clinical translation situ-formulated
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 30, 2025
Abstract Functional biomaterials composed of multiple biomacromolecules have significant advantages over those made from a single type. However, harmoniously integrating various remains challenging. Neutrophil extracellular traps (NETs), an emerging biological structure released neutrophils, serve as natural prototype worth investigating and learning from. NETs consist intricate exhibit web‐like microstructure, endowing them with multifaceted roles in both physiological pathological processes. In this review, research progress is systematically examined on materials science perspective. First, the origin transformation are introduced, their functional mechanisms NET components thoroughly dissected rather than conventionally treating entity. Second, given complex functions, revealed potential biomarker for disease prediction. Third, typical characterization technologies analysis summarized. Fourth, artificial inspired by discussed. addition, regulatory processes provide bio‐inspired prototypes design advanced materials. Finally, perspectives opportunities challenges advancing presented biomarkers models development
Language: Английский
Citations
0