Journal of Assisted Reproduction and Genetics, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Language: Английский
Journal of Assisted Reproduction and Genetics, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Language: Английский
Nature Cell Biology, Journal Year: 2022, Volume and Issue: 24(6), P. 968 - 980
Published: June 1, 2022
Language: Английский
Citations
111Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 124, P. 108531 - 108531
Published: Jan. 2, 2024
Language: Английский
Citations
19Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 93 - 93
Published: Jan. 17, 2025
Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, non-coding RNA activity—are crucial both for spermatogenesis sperm maturation. However, oxidative stress, driven excessive reactive oxygen species, disrupts these processes, leading to impaired function male infertility. This disruption extends epigenetic resulting in abnormal gene expression chromatin remodeling that compromise genomic integrity fertilization potential. Importantly, oxidative-stress-induced alterations can be inherited, affecting the fertility offspring future generations. review investigates how stress influences regulation reproduction modifying RNAs, ultimately compromising spermatogenesis. Additionally, it discusses transgenerational implications disruptions their potential role hereditary infertility disease predisposition. Understanding mechanisms vital developing therapeutic strategies mitigate damage restore homeostasis germline. By integrating insights from molecular, clinical, research, this work emphasizes need targeted interventions enhance prevent adverse outcomes progeny. Furthermore, elucidating dose–response relationships between changes remains a critical research priority, informing personalized diagnostics interventions. In context, studies should adopt standardized markers damage, robust clinical trials, multi-omic approaches capture complexity Such rigorous investigations will reduce risk disorders optimize outcomes.
Language: Английский
Citations
3International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 383 - 383
Published: Jan. 4, 2025
From fertilisation to delivery, calcium must be transported into and within the foetoplacental unit for intracellular signalling. This requires very rapid, precisely located Ca2+ transfers. In addition, from around eighth week of gestation, increasing amounts routed directly maternal blood foetus bone mineralisation through a flow-through system, which does not impact concentration. These different processes are mediated by numerous membrane-sited channels, transporters, exchangers. Understanding mechanisms is essential direct interventions optimise foetal development postnatal health protect mother pre-eclampsia. Ethical issues limit availability human tissue study. Our insight placental handling advancing rapidly, enabled developing genetic, analytical, computer technology. Because their diverse sources, reports new findings scattered. review aims pull data together highlight areas uncertainty. Areas needing clarification include trafficking, membrane expression, recycling channels transporters in microvilli; metabolism vitamin D gestational diabetes pre-eclampsia; vascular effects increased endothelial Orai expression pregnancy-specific beta-1-glycoproteins PSG1 PSG9.
Language: Английский
Citations
2Stem Cell Reports, Journal Year: 2020, Volume and Issue: 15(6), P. 1158 - 1175
Published: Oct. 8, 2020
Language: Английский
Citations
79Science Advances, Journal Year: 2021, Volume and Issue: 7(48)
Published: Nov. 24, 2021
Evolutionary analyses reveal conservation and divergence of epigenetic transition during early development across mammals.
Language: Английский
Citations
63Cold Spring Harbor Perspectives in Biology, Journal Year: 2021, Volume and Issue: 14(6), P. a039677 - a039677
Published: Aug. 16, 2021
Dramatic nuclear reorganization occurs during early development to convert terminally differentiated gametes a totipotent zygote, which then gives rise an embryo. Aberrant epigenome resetting severely impairs embryo and even leads lethality. How the epigenomes are inherited, reprogrammed, reestablished in this critical developmental period has gradually been unveiled through rapid of technologies including ultrasensitive chromatin analysis methods. In review, we summarize latest findings on epigenetic reprogramming gametogenesis embryogenesis, how it contributes gamete maturation parental-to-zygotic transition. Finally, highlight key questions that remain be answered fully understand regulation development.
Language: Английский
Citations
59Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Aug. 3, 2022
Abstract Establishment of the DNA methylation landscape mammalian oocytes, mediated by DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse high levels occur exclusively in transcriptionally active regions, with moderate to low other regions. Histone H3K36me3 mediates transcribed regions; however, it unknown which histone mark guides Here, we show that, H3K36me2 highly enriched X chromosome broadly distributed across all autosomes. Upon depletion, moderately methylated regions selectively affected, a pattern unique switched an autosome-like pattern. Furthermore, find that simultaneous depletion results global hypomethylation, comparable DNMT3A depletion. Therefore, two marks jointly provide chromatin platform essential guiding DNMT3A-dependent oocytes.
Language: Английский
Citations
49Journal of Assisted Reproduction and Genetics, Journal Year: 2022, Volume and Issue: 39(4), P. 801 - 816
Published: March 17, 2022
Abstract Epigenetics is the branch of genetics that studies different mechanisms influence gene expression without direct modification DNA sequence. An ever-increasing amount evidence suggests such regulatory processes may play a pivotal role both in initiation pregnancy and later embryonic fetal development, thus determining long-term effects even adult life. In this narrative review, we summarize current knowledge on epigenetics pregnancy, from its most studied well-known to new frontiers epigenetic regulation, as ncRNAs gestational environment brain development. Epigenetic are dynamic phenomenon responds maternal–fetal environmental factors, which can modify embryo-fetal development during various phases. Therefore, also recapitulate notable factors affect prenatal maternal nutrition, stress hormones, microbiome, teratogens, focusing their ability cause modifications ultimately fetus. Despite promising advancements more experience data topic still needed. A better understanding regulation could fact prove valuable towards management physiological pregnancies assisted reproduction treatments, other than allowing comprehend origin multifactorial pathological conditions neurodevelopmental disorders.
Language: Английский
Citations
46International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1459 - 1459
Published: Jan. 25, 2024
Mammalian fertilization initiates the reprogramming of oocytes and sperm, forming a totipotent zygote. During this intricate process, zygotic genome undergoes maternal-to-zygotic transition (MZT) subsequent activation (ZGA), marking initiation transcriptional control gene expression post-fertilization. Histone modifications are pivotal in shaping cellular identity many mammals. Recent advances chromatin analysis have enabled detailed explorations histone during ZGA. This review delves into conserved unique regulatory strategies, providing essential insights dynamic changes their variants ZGA The objective is to explore recent advancements leading mechanisms related governing embryonic development phase depth. These considerations will be useful for informing future therapeutic approaches that target epigenetic regulation diverse biological contexts. It also contribute extensive areas evolutionary developmental biology possibly lay foundation research discussion on seminal topic.
Language: Английский
Citations
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