Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100810 - 100810
Published: Sept. 22, 2023
Diabetic
wounds
(DWs)
pose
a
major
challenge
for
the
public
health
system
owing
to
their
high
incidence,
complex
pathogenesis,
and
long
recovery
time;
thus,
there
is
an
urgent
need
develop
innovative
therapies
accelerate
healing
process
of
diabetic
wounds.
As
natural
nanovesicles,
extracellular
vesicles
(EVs)
are
rich
in
sources
with
low
immunogenicity
abundant
nutritive
molecules
exert
potent
therapeutic
effects
on
wound
healing.
To
avoid
rapid
removal
EVs,
suitable
delivery
required
controlled
release.
Owing
advantages
porosity,
good
biocompatibility,
adjustable
physical
chemical
properties
hydrogels,
EV
biopotentiated
hydrogels
can
aid
achieving
precise
favorable
therapy
against
This
review
highlights
different
design
strategies,
effects,
mechanisms
hydrogels.
We
also
discussed
future
challenges
opportunities
using
Medicina,
Journal Year:
2021,
Volume and Issue:
57(10), P. 1072 - 1072
Published: Oct. 8, 2021
Diabetes
mellitus
is
an
increasingly
prevalent
chronic
metabolic
disease
characterized
by
prolonged
hyperglycemia
that
leads
to
long-term
health
consequences.
It
estimated
impaired
healing
of
diabetic
wounds
affects
approximately
25%
all
patients
with
diabetes
mellitus,
often
resulting
in
lower
limb
amputation,
subsequent
high
economic
and
psychosocial
costs.
The
hyperglycemic
environment
promotes
the
formation
biofilms
makes
difficult
treat.
In
this
review,
we
present
updates
regarding
recent
advances
our
understanding
pathophysiology
focusing
on
angiogenesis,
neuropathy,
sub-optimal
inflammatory
response,
barrier
disruption,
polymicrobial
infection,
followed
current
future
treatment
strategies
designed
tackle
various
pathologies
associated
wounds.
Given
alarming
increase
prevalence
diabetes,
subsequently
wounds,
it
imperative
target
multiple
causes
Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
22(7)
Published: April 7, 2022
Abstract
As
the
first
defensive
line
between
human
body
and
outside
world,
skin
is
vulnerable
to
damage
from
external
environment.
Skin
wounds
can
be
divided
into
acute
(mechanical
injuries,
chemical
surgical
wounds,
etc.)
chronic
(burns,
infections,
diabetes,
etc.).
In
order
manage
wound,
a
variety
of
wound
dressings
have
been
developed,
including
gauze,
films,
foams,
nanofibers,
hydrocolloids,
hydrogels.
Recently,
hydrogels
received
much
attention
because
their
natural
extracellular
matrix
(ECM)‐mimik
structure,
tunable
mechanical
properties,
facile
bioactive
substance
delivery
capability.
They
show
great
potential
application
in
repair.
This
paper
introduces
anatomy
function
skin,
process
healing
conventional
dressings,
then
composition
construction
methods
Next,
this
necessary
properties
repair
latest
research
progress
hydrogel
for
Finally,
future
development
goals
materials
field
are
proposed.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 27, 2023
Impaired
wound
healing
is
the
most
common
and
significant
complication
of
Diabetes.
While
other
complications
Diabetes
have
better
treatment
options,
diabetic
wounds
remain
a
burden
as
they
can
cause
pain
suffering
in
patients.
Wound
closure
repair
are
orchestrated
by
sequence
events
aided
release
pro-inflammatory
cytokines,
which
dysregulated
cases
Diabetes,
making
environment
unfavorable
for
delaying
processes.
This
concise
review
provides
an
overview
dysregulation
cytokines
offers
insights
into
therapeutic
outcomes.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 409 - 428
Published: April 21, 2023
Diabetic
wound
healing
has
become
a
serious
healthcare
challenge.
The
high-glucose
environment
leads
to
persistent
bacterial
infection
and
mitochondrial
dysfunction,
resulting
in
chronic
inflammation,
abnormal
vascular
function,
tissue
necrosis.
To
solve
these
issues,
we
developed
double-network
hydrogel,
constructed
with
pluronic
F127
diacrylate
(F127DA)
hyaluronic
acid
methacrylate
(HAMA),
enhanced
by
SS31-loaded
mesoporous
polydopamine
nanoparticles
(MPDA
NPs).
As
components,
SS31,
mitochondria-targeted
peptide,
maintains
reduces
reactive
oxygen
species
(ROS)
thus
regulates
macrophage
polarization,
as
well
promoting
cell
proliferation
migration,
while
MPDA
NPs
not
only
scavenge
ROS
exert
an
anti-bacterial
effect
photothermal
treatment
under
near-infrared
light
irradiation,
but
also
control
release
of
SS31
response
ROS.
This
F127DA/HAMA-MPDA@SS31
(FH-M@S)
hydrogel
characteristics
adhesion,
superior
biocompatibility
mechanical
properties
which
can
adapt
irregular
wounds
at
different
body
sites
provide
sustained
MPDA@SS31
(M@S)
NPs.
In
addition,
diabetic
rat
full
thickness
skin
defect
model,
the
FH-M@S
promoted
M2
collagen
deposition,
neovascularization
healing.
Therefore,
exhibits
promising
therapeutic
potential
for
regeneration.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 1537 - 1560
Published: March 1, 2023
Abstract:
Diabetes
mellitus
(DM)
induced
wound
healing
impairment
remains
a
serious
health
problem
and
burden
on
the
clinical
obligation
for
high
amputation
rates.
Based
features
of
microenvironment,
biomaterials
loading
specific
drugs
can
benefit
diabetic
treatment.
Drug
delivery
systems
(DDSs)
carry
diverse
functional
substances
to
site.
Nano-drug
(NDDSs),
benefiting
from
their
related
nano
size,
overcome
limitations
conventional
DDSs
application
are
considered
as
developing
process
in
treatment
field.
Recently,
number
finely
designed
nanocarriers
efficiently
various
(bioactive
non-bioactive
factors)
have
emerged
circumvent
constraints
faced
by
traditional
DDSs.
This
review
describes
recent
advances
nano-drug
involved
mitigating
diabetes
mellitus-based
non-healing
wounds.
Keywords:
drug
system,
nanotechnology,
healing,
nanoparticles
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 5, 2024
Diabetic
wounds
are
a
significant
subset
of
chronic
characterized
by
elevated
levels
inflammatory
cytokines,
matrix
metalloproteinases
(MMPs),
and
reactive
oxygen
species
(ROS).
They
also
associated
with
impaired
angiogenesis,
persistent
infection,
high
likelihood
hospitalization,
leading
to
substantial
economic
burden
for
patients.
In
severe
cases,
amputation
or
even
mortality
may
occur.
foot
ulcers
(DFUs)
common
complication
diabetes,
up
25%
diabetic
patients
being
at
risk
developing
over
their
lifetime,
more
than
70%
ultimately
requiring
amputation.
Electrospun
scaffolds
exhibit
structural
similarity
the
extracellular
(ECM),
promoting
adhesion,
growth,
migration
fibroblasts,
thereby
facilitating
formation
new
skin
tissue
wound
site.
The
composition
size
electrospun
can
be
easily
adjusted,
enabling
controlled
drug
release
through
fiber
structure
modifications.
porous
nature
these
facilitates
gas
exchange
absorption
exudate.
Furthermore,
surface
readily
modified
impart
specific
functionalities,
making
electrospinning
nanofiber
highly
promising
treatment
wounds.
This
article
provides
concise
overview
healing
process
in
normal
pathological
mechanisms
underlying
wounds,
including
complications
such
as
ulcers.
It
explores
advantages
treatment.
Additionally,
it
summarizes
findings
from
various
studies
on
use
different
types
reviews
methods
loading
onto
scaffolds.
These
advancements
broaden
horizon
effectively
treating
