Progress in 3D bioprinting technology for tissue/organ regenerative engineering

Biomaterials, Journal Year: 2019, Volume and Issue: 226, P. 119536 - 119536

Published: Oct. 11, 2019

Language: Английский

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Acoustic tweezers for the life sciences

Nature Methods, Journal Year: 2018, Volume and Issue: 15(12), P. 1021 - 1028

Published: Nov. 14, 2018

Language: Английский

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Fuel‐Free Synthetic Micro‐/Nanomachines

Advanced Materials, Journal Year: 2016, Volume and Issue: 29(9)

Published: Dec. 27, 2016

Inspired by the swimming of natural microorganisms, synthetic micro‐/nanomachines, which convert energy into movement, are able to mimic function these amazing systems and help humanity completing environmental biological tasks. While offering autonomous propulsion, conventional micro‐/nanomachines usually rely on decomposition external chemical fuels (e.g., H 2 O ), greatly hinders their applications in biologically relevant media. Recent developments have resulted various micro‐/nanomotors that can be powered biocompatible fuels. Fuel‐free micro‐/nanomotors, move without fuels, represent another attractive solution for practical owing biocompatibility sustainability. Here, recent fuel‐free (powered stimuli such as light, magnetic, electric, or ultrasonic fields) summarized, ranging from fabrication propulsion mechanisms. The also discussed, including nanopatterning, targeted drug/gene delivery, cell manipulation, precision nanosurgery. With continuous innovation, future autonomous, intelligent multifunctional expected a profound impact upon diverse biomedical applications, providing unlimited opportunities beyond one's imagination.

Language: Английский

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Bioprinting: From Tissue and Organ Development to in Vitro Models

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(19), P. 10547 - 10607

Published: May 14, 2020

Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments past years. Novel biomaterial inks used for formation bioinks developed, allowing manufacturing vitro models implants tested preclinically a certain degree success. Furthermore, incredible advances cell biology, namely, pluripotent stem cells, also contributed to latest milestones where more relevant tissues or organ-like constructs functionality can already be obtained. These strides possible multitude multidisciplinary teams around world, working make bioprinted organs functional. Yet, there is still long way go until these biofabricated will able reach clinics. In this review, we summarize main bioprinting activities linking them tissue organ development physiology. Most approaches focus on mimicking fully matured tissues. Future strategies might pursue earlier developmental stages organs. The continuous convergence experts fields material sciences, engineering, many other disciplines gradually allow us overcome barriers identified demanding path toward adoption replacements.

Language: Английский

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Recent advances in microfluidic technologies for cell-to-cell interaction studies

Lab on a Chip, Journal Year: 2017, Volume and Issue: 18(2), P. 249 - 270

Published: Oct. 31, 2017

Microfluidic cell cultures are ideally positioned to become the next generation of in vitro diagnostic tools for biomedical research, where key biological processes such as signalling and dynamic cell-to-cell interactions can be reliably analysed under reproducible physiological culture conditions. In last decade, a large number microfluidic analysis systems have been developed variety applications including drug target optimization, screening toxicological testing. More recently, advanced emerged that capable replicating complex three-dimensional architectures tissues organs thus represent valid models investigating mechanism function human tissue structures, well studying onset progression diseases cancer. this review, we present most important developments single-cell, 2D 3D published over 6 years, with focus on cancer research immunotherapy, vascular neuroscience. addition, current technological development microdevices more microenvironments integrate multiple organ models, namely, so-called body-, human- multi-organ-on-a-chip, is reviewed.

Language: Английский

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Acoustic Microfluidics

Annual Review of Analytical Chemistry, Journal Year: 2020, Volume and Issue: 13(1), P. 17 - 43

Published: June 12, 2020

Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible contactless operation, label-free nature all characteristics make acoustic ideal platforms for fundamental research, diagnostics, therapeutics. Herein, we summarize the physical principles underlying microfluidics review their applications, with particular emphasis on manipulation of macromolecules, cells, particles, model organisms, fluidic flows. We also present future goals this technology biomedical as well challenges opportunities.

Language: Английский

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Ultrasound propulsion of micro-/nanomotors

Applied Materials Today, Journal Year: 2017, Volume and Issue: 9, P. 493 - 503

Published: Oct. 14, 2017

Language: Английский

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Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(4)

Published: Nov. 29, 2019

Abstract Acoustophoresis is promising as a rapid, biocompatible, noncontact cell manipulation method, where cells are arranged along the nodes or antinodes of acoustic field. Typically, field formed in resonator, which results highly symmetric regular patterns. However, arbitrary, nonsymmetrically shaped assemblies necessary to obtain irregular cellular arrangements found biological tissues. It shown that arbitrarily patterns can be obtained from complex distribution defined by an hologram. Attenuation sound induces localized streaming and resultant convection flow gently delivers suspended image plane they form designed pattern. process implemented biocompatible collagen solution, then undergo gelation immobilize pattern inside viscoelastic matrix. The patterned exhibit F‐actin‐based protrusions, indicate grow thrive within Cell viability assays brightfield imaging after one week confirm survival persist. Acoustophoretic holographic fields thus holds promise for noncontact, long‐range, long‐term formation, with wide variety potential applications tissue engineering mechanobiology.

Language: Английский

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Continuous micro-vortex-based nanoparticle manipulation via focused surface acoustic waves

Lab on a Chip, Journal Year: 2016, Volume and Issue: 17(1), P. 91 - 103

Published: Nov. 17, 2016

Continuous manipulation of nanoparticles using micro-vortex generated by a highly focused, high frequency surface acoustic wave (SAW) beam.

Language: Английский

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Wave number–spiral acoustic tweezers for dynamic and reconfigurable manipulation of particles and cells

Science Advances, Journal Year: 2019, Volume and Issue: 5(5)

Published: May 3, 2019

Acoustic tweezers have recently raised great interest across many fields including biology, chemistry, engineering, and medicine, as they can perform contactless, label-free, biocompatible, precise manipulation of particles cells. Here, we present wave number-spiral acoustic tweezers, which are capable dynamically reshaping surface (SAW) wavefields to various pressure distributions facilitate dynamic programmable particle/cell manipulation. SAWs propagating in multiple directions be simultaneously independently controlled by simply modulating the multitone excitation signals. This allows for SAW desired distributions, thus achieving We experimentally demonstrated functions among multiconfiguration patterning; parallel merging; pattern translation, transformation, rotation; translation single microparticles along complex paths. design has potential revolutionize future development advance applications, microscale assembly, bioprinting, cell-cell interaction research.

Language: Английский

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