Impact of Microplastics on Human Health: Risks, Diseases, and Affected Body Systems DOI Creative Commons
Ghulam Abbas,

Usama Ahmed,

Muhammad Arslan Ahmad

et al.

Microplastics, Journal Year: 2025, Volume and Issue: 4(2), P. 23 - 23

Published: May 7, 2025

This review article aims to highlight the potential harm caused by microplastics (MPs) in different organs and systems underscore need for further investigation into their action mechanisms. MPs, such as polystyrene, polypropylene, polyethylene, significantly impact human health, causing inflammation respiratory gastrointestinal systems, compromising immune function, increasing risk of cardiovascular diseases neurotoxicity. These effects are largely attributed role MPs disrupting hormonal regulation, which can lead reproductive disorders an elevated cancer. microscopic particles (less than 5 mm size) now ubiquitous air, water, food. However, much existing research on focuses mechanisms association with health disease, limited emphasis direct humans or long-term consequences. To effectively address plastic toxicity, it is crucial understand policy implications relevance disease development. Recent has highlighted more stringent regulatory oversight these materials better mitigate health.

Language: Английский

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms DOI Open Access
Ming‐Chang Chiang, Tsung‐Yu Tsai,

Chieh-Ju Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6328 - 6328

Published: March 28, 2023

Neuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing damage contributing the onset progression of various Therefore, understanding mechanisms strategies control them crucial for treating Studies have shown that plays vital role such as Alzheimer's (AD) Parkinson's (PD), stroke. Additionally, effects PM

Language: Английский

Citations

87
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses DOI Creative Commons
Mohammad Nasb,

Weichu Tao,

Ning Chen

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 8, 2023

Alzheimer's disease (AD) is a prevalent neurodegenerative characterized by both amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of all dementia cases worldwide. With the increasing number AD patients, elucidating underlying mechanisms developing corresponding interventional strategies are necessary. Hypotheses about such as amyloid cascade, Tau hyper-phosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, cholinergic, vascular hypotheses not mutually exclusive, them play certain role in development AD. The cascade hypothesis currently most widely studied; however, other also gaining support. This article summarizes recent evidence regarding major pathological their potential interplay, well strengths weaknesses each implications effective treatments. could stimulate further studies promote more therapeutic

Language: Английский

Citations

69
Advancing Health Equity through 15-min Cities and Chrono-urbanism DOI
David Rojas‐Rueda,

Michelle Norberciak,

Emily Morales-Zamora

et al.

Journal of Urban Health, Journal Year: 2024, Volume and Issue: 101(3), P. 483 - 496

Published: May 14, 2024

Language: Английский

Citations

9
Novel perspective on particulate matter and Alzheimer's disease: insights from adverse outcome pathway framework DOI

Shuang-Jian Qin,

Qing-Guo Zeng,

Hui-Xian Zeng

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125601 - 125601

Published: Jan. 1, 2025

Language: Английский

Citations

1
A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia DOI Creative Commons
Xinmei Huang, Jaimie D Steinmetz, Elizabeth K. Marsh

et al.

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Previous studies have indicated increased dementia risk associated with fine particulate matter (PM 2.5 ) exposure; however, the findings are inconsistent. In this systematic review, we assessed association between long-term PM exposure and outcomes using Burden of Proof meta-analytic framework, which relaxes log-linear assumptions to better characterize relative functions quantify unexplained between-study heterogeneity (PROSPERO, ID CRD42023421869). Here report a meta-analysis 28 longitudinal cohort published up June 2023 that investigated outcomes. We derived risk–outcome scores (ROSs), highly conservative measures effect size evidence strength, mapped onto 1–5-star rating from ‘weak and/or inconsistent evidence’ ‘very strong consistent evidence’. identified significant nonlinear relationship dementia, minimum 14% averaged across levels 4.5 26.9 µg m −3 (the 15th 85th percentile range included studies), reference 2.0 ( n = 49, ROS 0.13, two stars). found Alzheimer’s disease 12, 0.32, three stars) but not vascular dementia. Our highlight potential impact air pollution on brain aging.

Language: Английский

Citations

1
Particulate matter exposure from motorized traffic and risk of conversion from mild cognitive impairment to dementia: An Italian prospective cohort study DOI Creative Commons
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 222, P. 115425 - 115425

Published: Feb. 3, 2023

Based on epidemiologic and laboratory studies, exposure to air pollutants has been linked many adverse health effects including a higher risk of dementia. In this study, we aimed evaluate the effect long-term outdoor pollution conversion dementia in cohort subjects with mild cognitive impairment (MCI).We recruited 53 Italian newly-diagnosed MCI. Within geographical information system, assessed recent pollutant exposure, by modeling levels particulate matter equivalent aerodynamic diameter ≤10 μm (PM10) from motorized traffic at participants' residence. We investigated relation PM10 concentrations subsequent MCI any type Using Cox-proportional hazards model combined restricted cubic spline model, computed hazard ratio (HR) its 95% confidence interval (CI) according increasing adjusting for sex, age, educational attainment.During median follow up 47.3 months, 34 participants developed dementia, 26 cases diagnosed as Alzheimer's non-linear regression analysis, mean maximum annual positively correlated cerebrospinal fluid total phosphorylated tau proteins concentrations, while they were inversely associated β-amyloid. Concerning found positive association starting above 10 μg/m3 35 levels. Specific estimates substantially similar. Adding other potential confounders multivariable or removing early onset during follow-up had little estimates.Our findings suggest that pollutants, particular, may non-linearly increase certain ambient concentration.

Language: Английский

Citations

19
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework DOI

Shuang-Jian Qin,

Qing-Guo Zeng,

Hui-Xian Zeng

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174450 - 174450

Published: July 3, 2024

Language: Английский

Citations

7
Imperfect wound healing sets the stage for chronic diseases DOI
Paul Martin, Carlos Pardo-Pastor, Gisli Jenkins

et al.

Science, Journal Year: 2024, Volume and Issue: 386(6726)

Published: Dec. 5, 2024

Although the age of genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise from mutations alone; rather, they develop as we age. In this Review, examine wound healing might act to ignite disease. Wound works well when are younger, repairing damage accidents, environmental assaults, and battles pathogens. Yet, accumulation tissue damage, repair process can devolve, leading inflammation, fibrosis, neoplastic signaling. We discuss healthy responses bodies misappropriate these pathways in focus predominantly on epithelial-based (lung skin) diseases, similar operate cardiac, muscle, neuronal diseases.

Language: Английский

Citations

6
Intersectionality in Alzheimer's Disease: The Role of Female Sex and Black American Race in the Development and Prevalence of Alzheimer's Disease DOI Creative Commons
Maria Misiura, Brittany Butts,

Bruno L. Hammerschlag

et al.

Neurotherapeutics, Journal Year: 2023, Volume and Issue: 20(4), P. 1019 - 1036

Published: July 1, 2023

Language: Английский

Citations

16
Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe DOI Creative Commons
Jeroen de Bont,

Regina Pickford,

Christofer Åström

et al.

Environment International, Journal Year: 2023, Volume and Issue: 179, P. 108136 - 108136

Published: Aug. 10, 2023

The complex interplay of multiple environmental factors and cardiovascular has scarcely been studied. Within the EXPANSE project, we evaluated association between long-term exposure to indices stroke incidence across Europe. Participants from three traditional adult cohorts (Germany, Netherlands Sweden) four administrative (Catalonia [region Spain], Rome [city-wide], Greece Sweden [nationwide]) were followed until incident stroke, death, migration, loss follow-up or study end. We estimated exposures at residential addresses different domains: air pollution (nitrogen dioxide (NO2), particulate matter <2.5μm (PM2.5), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) meteorology (seasonal mean standard deviation temperatures). Associations in single multiple-exposure Cox proportional hazard models, Principal Component (PC) Analyses derived prototypes for specific domains. carried out random effects meta-analyses by cohort type. In over 15 million participants, increased levels NO2 BC associated with higher both types. Increased Normalized Difference Vegetation Index (NDVI) was a lower types, whereas an increase surface incidence. first PC domain (PM2.5, BC) For environment, NDVI surfaces protective effect [%change HR per 1 unit = -2.0 (95%CI, -5.9;2.0) -1.1(95%CI, -2.0;-0.3) cohorts, respectively]. No clear patterns observed distance blue spaces temperature parameters. HRs PM2.5, BC, greenness combined models.

Language: Английский

Citations

12