Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function DOI Creative Commons
Cristiana Iosef, Michael J. Knauer,

Michael Nicholson

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 10, 2023

Long-COVID occurs after SARS-CoV-2 infection and results in diverse, prolonged symptoms. The present study aimed to unveil potential mechanisms, inform prognosis treatment.Plasma proteome from outpatients was analyzed comparison matched acutely ill COVID-19 (mild severe) inpatients healthy control subjects. expression of 3072 protein biomarkers determined with proximity extension assays then deconvoluted multiple bioinformatics tools into both cell types signaling as well organ specificity.Compared age- sex-matched subjects, showed natural killer redistribution a dominant resting phenotype, opposed active, neutrophils that formed extracellular traps. This resetting phenotypes reflected prospective vascular events mediated by angiopoietin-1 (ANGPT1) vascular-endothelial growth factor-A (VEGFA). Several markers (ANGPT1, VEGFA, CCR7, CD56, citrullinated histone 3, elastase) were validated serological methods additional patient cohorts. Signaling transforming factor-β1 probable connections elevated EP/p300 suggested inflammation tumor necrosis factor-α driven pathways. In addition, proliferative state associated hypoxia inducible factor 1 pathway progression acute Long-COVID. vasculo-proliferative process predicted might contribute changes the organ-specific reflective neurologic cardiometabolic dysfunction.Taken together, our findings point is likely initiated either prior (localized or systemic) and/or stimulatory factors (i.e., cytokines, chemokines, factors, angiotensin, etc). Analyses plasma proteome, used surrogate for cellular signaling, unveiled prognostic therapeutic targets.

Language: Английский

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions DOI Creative Commons
Valentina Carlini, Douglas M. Noonan,

Eslam Abdalalem

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Interleukin-10 (IL-10) is a pleiotropic cytokine that has fundamental role in modulating inflammation and maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from uncontrolled immune response, mostly through Jak1/Tyk2 STAT3 signaling pathway. On other hand, IL-10 can also have immunostimulating functions under certain conditions. Given pivotal of modulation, this could relevant implications pathologies characterized by hyperinflammatory state, such cancer, or infectious diseases case COVID-19 Post-COVID-19 syndrome. Recent evidence proposed predictor severity mortality for patients with acute post-acute SARS-CoV-2 infection. In context, act endogenous danger signal, released tissues undergoing damage attempt to protect organism harmful hyperinflammation. Pharmacological strategies aimed potentiate restore immunomodulatory action may represent novel promising avenues counteract storm arising hyperinflammation effectively mitigate severe complications. Natural bioactive compounds, derived terrestrial marine photosynthetic organisms able increase expression, useful prevention strategy curb elevation will be discussed here. However, multifaceted nature taken into account attempts modulate its levels.

Language: Английский

Citations

197
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC) DOI Creative Commons
Zaki A. Sherif, Christian R. Gómez, Thomas J. Connors

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 22, 2023

COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, cognitive dysfunction that last for months impact everyday functioning, is referred to Long COVID under the general category post-acute sequelae SARS-CoV-2 infection (PASC). PASC highly heterogenous may be associated multisystem tissue damage/dysfunction including acute encephalitis, cardiopulmonary syndromes, fibrosis, hepatobiliary damages, gastrointestinal dysregulation, myocardial infarction, neuromuscular neuropsychiatric disorders, pulmonary damage, renal failure, stroke, vascular endothelial dysregulation. A better understanding pathophysiologic mechanisms underlying essential guide prevention treatment. This review addresses potential hypotheses connect long-term health consequences. Comparisons between other virus-initiated chronic syndromes myalgic encephalomyelitis/chronic fatigue syndrome postural orthostatic tachycardia will addressed. Aligning identifying potentially regulated common underlining pathways necessary true nature PASC. The discussed contributors include from injury one or more organs, reservoirs replicating virus its remnants in several tissues, re-activation latent pathogens Epstein-Barr herpes viruses COVID-19 immune-dysregulated environment, interactions host microbiome/virome communities, clotting/coagulation dysfunctional brainstem/vagus nerve signaling, dysautonomia autonomic dysfunction, ongoing activity primed immune cells, autoimmunity due molecular mimicry pathogen proteins. individualized suggests different therapeutic approaches required best manage specific patients.

Language: Английский

Citations

165
Effect of COVID-19 Vaccines on Reducing the Risk of Long COVID in the Real World: A Systematic Review and Meta-Analysis DOI Open Access
Peng Gao, Jue Liu, Min Liu

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(19), P. 12422 - 12422

Published: Sept. 29, 2022

The coronavirus disease 2019 (COVID-19) is still in a global pandemic state. Some studies have reported that COVID-19 vaccines had protective effect against long COVID. However, the conclusions of on COVID were not consistent. This study aimed to systematically review relevant real world, and performed meta-analysis explore relationship between vaccination We searched PubMed, Embase, Web science, ScienceDirect from inception 19 September 2022. PICO (P: patients; I: intervention; C: comparison; O: outcome) was as follows: patients diagnosed with (P); (I); divided into vaccinated unvaccinated groups (C); outcomes occurrence COVID, well various symptoms (O). A fixed-effect model random-effects chosen based heterogeneity order pool value. results showed group 29% lower risk developing compared (RR = 0.71, 95% CI: 0.58-0.87,

Language: Английский

Citations

162
Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations on recovery from post-COVID-19 conditions: the RECOVE trial DOI
Amaya Jimeno‐Almazán, Ángel Buendía‐Romero, Alejandro Martínez‐Cava

et al.

Journal of Applied Physiology, Journal Year: 2022, Volume and Issue: 134(1), P. 95 - 104

Published: Dec. 8, 2022

Eight weeks of concurrent training, with or without inspiratory muscle exercise, was better than WHO “Support for Rehabilitation: Self-Management after COVID-19-Related Illness” recommendations training alone to improve cardiopulmonary fitness, strength, and symptom severity, in a safe effective manner. The RECOVE trial proved the benefits utility supervised exercise program people post-COVID-19 conditions mild COVID-19 an ambulatory setting.

Language: Английский

Citations

104
Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation DOI Open Access
Sally Singh, Molly M Baldwin, Enya Daynes

et al.

The Lancet Respiratory Medicine, Journal Year: 2023, Volume and Issue: 11(8), P. 709 - 725

Published: May 19, 2023

Language: Английский

Citations

104
Long COVID prevalence and impact on quality of life 2 years after acute COVID-19 DOI Creative Commons
Yoonjung Kim, Sohyun Bae, Hyun‐Ha Chang

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 11, 2023

There has been an increasing interest in the long-term impact of long COVID. However, only a few studies have investigated clinical manifestations COVID after 24 months acute infection. In this study, prospective online surveys were conducted adults previously diagnosed with coronavirus disease 2019 (COVID-19) South Korea between February 13 and March 13, 2020, at 6, 12, COVID-19. We self-reported symptoms EuroQol-5-dimension index. Among 900 individuals enrolled initially, 150 completed all 3 surveys. After excluding cases COVID-19 reinfection, 132 included final analysis. participants, 94 (71.2%) experienced The most frequently reported fatigue (34.8%), amnesia (30.3%), concentration difficulties (24.2%), insomnia (20.5%), depression (19.7%). Notably, no significant differences noted incidence terms number vaccinations received. Although neuropsychiatric quality life improved over time, it continued to affect 32.7% participants. Symptoms COVID, particularly symptoms, tend persist vaccination or received may not significantly

Language: Английский

Citations

103
Long COVID: a clinical update DOI
Trisha Greenhalgh, Manoj Sivan,

Alice Perlowski

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 404(10453), P. 707 - 724

Published: July 31, 2024

Language: Английский

Citations

103
Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis DOI Creative Commons
César Fernández‐de‐las‐Peñas, Kin Israel Notarte, Raymart Macasaet

et al.

Journal of Infection, Journal Year: 2023, Volume and Issue: 88(2), P. 77 - 88

Published: Dec. 13, 2023

This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection.

Language: Английский

Citations

92
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey DOI
Raffaele Izzo, Valentina Trimarco, Pasquale Mone

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 183, P. 106360 - 106360

Published: July 19, 2022

Language: Английский

Citations

78
Living with “long COVID”: A systematic review and meta-synthesis of qualitative evidence DOI Creative Commons
Md Mahbub Hossain, Jyoti Das, Farzana Rahman

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(2), P. e0281884 - e0281884

Published: Feb. 16, 2023

Objectives Long-term health consequences of coronavirus disease (COVID-19), also known as “long COVID,” has become a global concern. In this systematic review, we aimed to synthesize the qualitative evidence on lived experiences people living with long COVID that may inform policymaking and practice. Methods We searched six major databases additional sources systematically retrieved relevant studies conducted meta-synthesis key findings using Joanna Briggs Institute (JBI) guidelines reporting standards Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) checklist. Results found 15 articles representing 12 out 619 citations from different sources. These provided 133 were categorized into 55 categories. All categories aggregated following synthesized findings: complex physical problems, psychosocial crises COVID, slow recovery rehabilitation, digital resources information management, changes in social support, healthcare providers, services, systems. Ten UK, others Denmark Italy, which highlights critical lack other countries. Conclusions More representative research is needed understand COVID-related diverse communities populations. The available informs high burden biopsychosocial challenges among would require multilevel interventions such strengthening policies engaging patients caregivers making decisions developing resources, addressing socioeconomic disparities associated through evidence-based

Language: Английский

Citations

70