Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 8, 2023
Interleukin-10
(IL-10)
is
a
pleiotropic
cytokine
that
has
fundamental
role
in
modulating
inflammation
and
maintaining
cell
homeostasis.
It
primarily
acts
as
an
anti-inflammatory
cytokine,
protecting
the
body
from
uncontrolled
immune
response,
mostly
through
Jak1/Tyk2
STAT3
signaling
pathway.
On
other
hand,
IL-10
can
also
have
immunostimulating
functions
under
certain
conditions.
Given
pivotal
of
modulation,
this
could
relevant
implications
pathologies
characterized
by
hyperinflammatory
state,
such
cancer,
or
infectious
diseases
case
COVID-19
Post-COVID-19
syndrome.
Recent
evidence
proposed
predictor
severity
mortality
for
patients
with
acute
post-acute
SARS-CoV-2
infection.
In
context,
act
endogenous
danger
signal,
released
tissues
undergoing
damage
attempt
to
protect
organism
harmful
hyperinflammation.
Pharmacological
strategies
aimed
potentiate
restore
immunomodulatory
action
may
represent
novel
promising
avenues
counteract
storm
arising
hyperinflammation
effectively
mitigate
severe
complications.
Natural
bioactive
compounds,
derived
terrestrial
marine
photosynthetic
organisms
able
increase
expression,
useful
prevention
strategy
curb
elevation
will
be
discussed
here.
However,
multifaceted
nature
taken
into
account
attempts
modulate
its
levels.
COVID-19,
with
persistent
and
new
onset
of
symptoms
such
as
fatigue,
post-exertional
malaise,
cognitive
dysfunction
that
last
for
months
impact
everyday
functioning,
is
referred
to
Long
COVID
under
the
general
category
post-acute
sequelae
SARS-CoV-2
infection
(PASC).
PASC
highly
heterogenous
may
be
associated
multisystem
tissue
damage/dysfunction
including
acute
encephalitis,
cardiopulmonary
syndromes,
fibrosis,
hepatobiliary
damages,
gastrointestinal
dysregulation,
myocardial
infarction,
neuromuscular
neuropsychiatric
disorders,
pulmonary
damage,
renal
failure,
stroke,
vascular
endothelial
dysregulation.
A
better
understanding
pathophysiologic
mechanisms
underlying
essential
guide
prevention
treatment.
This
review
addresses
potential
hypotheses
connect
long-term
health
consequences.
Comparisons
between
other
virus-initiated
chronic
syndromes
myalgic
encephalomyelitis/chronic
fatigue
syndrome
postural
orthostatic
tachycardia
will
addressed.
Aligning
identifying
potentially
regulated
common
underlining
pathways
necessary
true
nature
PASC.
The
discussed
contributors
include
from
injury
one
or
more
organs,
reservoirs
replicating
virus
its
remnants
in
several
tissues,
re-activation
latent
pathogens
Epstein-Barr
herpes
viruses
COVID-19
immune-dysregulated
environment,
interactions
host
microbiome/virome
communities,
clotting/coagulation
dysfunctional
brainstem/vagus
nerve
signaling,
dysautonomia
autonomic
dysfunction,
ongoing
activity
primed
immune
cells,
autoimmunity
due
molecular
mimicry
pathogen
proteins.
individualized
suggests
different
therapeutic
approaches
required
best
manage
specific
patients.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(19), P. 12422 - 12422
Published: Sept. 29, 2022
The
coronavirus
disease
2019
(COVID-19)
is
still
in
a
global
pandemic
state.
Some
studies
have
reported
that
COVID-19
vaccines
had
protective
effect
against
long
COVID.
However,
the
conclusions
of
on
COVID
were
not
consistent.
This
study
aimed
to
systematically
review
relevant
real
world,
and
performed
meta-analysis
explore
relationship
between
vaccination
We
searched
PubMed,
Embase,
Web
science,
ScienceDirect
from
inception
19
September
2022.
PICO
(P:
patients;
I:
intervention;
C:
comparison;
O:
outcome)
was
as
follows:
patients
diagnosed
with
(P);
(I);
divided
into
vaccinated
unvaccinated
groups
(C);
outcomes
occurrence
COVID,
well
various
symptoms
(O).
A
fixed-effect
model
random-effects
chosen
based
heterogeneity
order
pool
value.
results
showed
group
29%
lower
risk
developing
compared
(RR
=
0.71,
95%
CI:
0.58-0.87,
Journal of Applied Physiology,
Journal Year:
2022,
Volume and Issue:
134(1), P. 95 - 104
Published: Dec. 8, 2022
Eight
weeks
of
concurrent
training,
with
or
without
inspiratory
muscle
exercise,
was
better
than
WHO
“Support
for
Rehabilitation:
Self-Management
after
COVID-19-Related
Illness”
recommendations
training
alone
to
improve
cardiopulmonary
fitness,
strength,
and
symptom
severity,
in
a
safe
effective
manner.
The
RECOVE
trial
proved
the
benefits
utility
supervised
exercise
program
people
post-COVID-19
conditions
mild
COVID-19
an
ambulatory
setting.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: July 11, 2023
There
has
been
an
increasing
interest
in
the
long-term
impact
of
long
COVID.
However,
only
a
few
studies
have
investigated
clinical
manifestations
COVID
after
24
months
acute
infection.
In
this
study,
prospective
online
surveys
were
conducted
adults
previously
diagnosed
with
coronavirus
disease
2019
(COVID-19)
South
Korea
between
February
13
and
March
13,
2020,
at
6,
12,
COVID-19.
We
self-reported
symptoms
EuroQol-5-dimension
index.
Among
900
individuals
enrolled
initially,
150
completed
all
3
surveys.
After
excluding
cases
COVID-19
reinfection,
132
included
final
analysis.
participants,
94
(71.2%)
experienced
The
most
frequently
reported
fatigue
(34.8%),
amnesia
(30.3%),
concentration
difficulties
(24.2%),
insomnia
(20.5%),
depression
(19.7%).
Notably,
no
significant
differences
noted
incidence
terms
number
vaccinations
received.
Although
neuropsychiatric
quality
life
improved
over
time,
it
continued
to
affect
32.7%
participants.
Symptoms
COVID,
particularly
symptoms,
tend
persist
vaccination
or
received
may
not
significantly
PLoS ONE,
Journal Year:
2023,
Volume and Issue:
18(2), P. e0281884 - e0281884
Published: Feb. 16, 2023
Objectives
Long-term
health
consequences
of
coronavirus
disease
(COVID-19),
also
known
as
“long
COVID,”
has
become
a
global
concern.
In
this
systematic
review,
we
aimed
to
synthesize
the
qualitative
evidence
on
lived
experiences
people
living
with
long
COVID
that
may
inform
policymaking
and
practice.
Methods
We
searched
six
major
databases
additional
sources
systematically
retrieved
relevant
studies
conducted
meta-synthesis
key
findings
using
Joanna
Briggs
Institute
(JBI)
guidelines
reporting
standards
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analysis
(PRISMA)
checklist.
Results
found
15
articles
representing
12
out
619
citations
from
different
sources.
These
provided
133
were
categorized
into
55
categories.
All
categories
aggregated
following
synthesized
findings:
complex
physical
problems,
psychosocial
crises
COVID,
slow
recovery
rehabilitation,
digital
resources
information
management,
changes
in
social
support,
healthcare
providers,
services,
systems.
Ten
UK,
others
Denmark
Italy,
which
highlights
critical
lack
other
countries.
Conclusions
More
representative
research
is
needed
understand
COVID-related
diverse
communities
populations.
The
available
informs
high
burden
biopsychosocial
challenges
among
would
require
multilevel
interventions
such
strengthening
policies
engaging
patients
caregivers
making
decisions
developing
resources,
addressing
socioeconomic
disparities
associated
through
evidence-based