Unveiling the therapeutic potential and nanotechnological approaches for the delivery of tanshinone IIA DOI Creative Commons

Diya Arora,

Vanshita Singh,

Keshav Bansal

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100494 - 100494

Published: Aug. 9, 2024

Phytochemicals, as dietary ingredients, are being extensively studied for the treatment and prevention of many illnesses. Tanshinone IIA, a plant-derived diterpene quinone has demonstrated various therapeutic effects. However, limitations like low solubility, bioavailability stability, weak targeting biodistribution, short half-life make Tan IIA an unlikely candidate effective therapy. Nanoformulations based on natural substances gaining interest approach human diseases, they provide alternative to conventional approaches, which frequently linked with number adverse effects complications. The study comprises thorough assessment existing research findings from variety sources in order collect data properties innovative delivery systems. Literature was compiled databases, including Scopus, Embase, PubMed, Google Scholar, using keywords such "Tanshinone IIA" or "diterpenes" combination "Traditional Chinese medicine", "Therapeutic potential", "Neuroprotection", "Anti-cancer", "Cardioprotection", "Nanocarriers", "Liposomes". that possesses broad array pharmacological its antidiabetic, anticancer, antioxidant, anti-inflammatory activities. nanoformulations have shown good encapsulation efficiency, sustained release, extended circulation duration, increased accumulation at diseased sites, improved efficacy, leading effectiveness plethora disorders. Nanostructured particles several benefits addressing issues limited stability phytochemicals by overcoming biological barriers. Certainly, use nano-drug carriers plant products is current trend. Furthermore, applications these must be humans. Such investigation, well evaluation dosage optimization, may pave way IIA's commercial feasibility.

Language: Английский

Chitosan-based hydrogels: From preparation to applications, a review DOI Creative Commons

Fandi Hong,

Peng Qiu, Yufan Wang

et al.

Food Chemistry X, Journal Year: 2023, Volume and Issue: 21, P. 101095 - 101095

Published: Dec. 27, 2023

Chitosan, derived from the deacetylation of chitin, is an abundant natural biopolymer on earth. Chitosan and its derivatives have become promising biological materials because their unique molecular structure excellent activities. The reactive functional groups chitosan such as amino hydroxyl play a crucial role in facilitating synthesis three-dimensional hydrogel. Chitosan-based hydrogels been widely used medical, pharmaceutical, environmental fields for years. Nowadays, chitosan-based found wide range applications food industry sensors, dye adsorbents nutrient carriers. In this review, recently developed methods preparation were given, activities systematically introduced. Additionally, recent progress packaging, adsorbents, carriers was discussed. Finally, challenges prospects future development

Language: Английский

Citations

83
Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds DOI Open Access

Fabrizia Sepe,

Anna Valentino, Loredana Marcolongo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 764 - 764

Published: Jan. 17, 2025

Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds medical purposes. These hydrogels, which exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices encapsulating different molecules. In addition, by modifying physical chemical properties marine including cross-linking density, swelling behavior, response to external stimuli like pH, temperature, or ionic strength, profile encapsulated is strictly regulated, thus maximizing therapeutic efficacy minimizing side effects. Finally, using naturally sourced polysaccharides hydrogel formulations, sustainability promoted reducing dependence on synthetic polymers, meeting growing demand eco-friendly materials. This review analyzes interaction between offers examples how molecules can be encapsulated, released, stabilized.

Language: Английский

Citations

2
Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives DOI Open Access
Indra Jaya Budiarso, Novi Dwi Widya Rini, Annisa Tsalsabila

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3084 - 3115

Published: May 13, 2023

Over the past decade, smart and functional biomaterials have escalated as one of most rapidly emerging fields in life sciences because performance could be improved by careful consideration their interaction response with living systems. Thus, chitosan play a crucial role this frontier field it possesses many beneficial properties, especially biomedical such excellent biodegradability, hemostatic antibacterial activity, antioxidant biocompatibility, low toxicity. Furthermore, is versatile biopolymer due to its polycationic nature reactive groups that allow polymer form interesting structures or modified various ways suit targeted applications. In review, we provide an up-to-date development chitosan-based nanoparticles, hydrogels, nanofibers, films, well application field. This review also highlights several strategies enhance biomaterial for fast growing applications drug delivery systems, bone scaffolds, wound healing, dentistry.

Language: Английский

Citations

38
A tannic acid/phosphazene-based multifunctional coating: Integrating flame retardancy, hydrophobicity, antibacterial property, and UV resistance into cotton DOI
Tiantian Huang, Hui Yan, Congyun Zhang

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 119686 - 119686

Published: Sept. 19, 2024

Language: Английский

Citations

14
Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications DOI Creative Commons
Nicoleta Mirela Blebea, Ciprian Pușcașu, Robert-Alexandru Vlad

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 275 - 275

Published: April 6, 2025

Chitosan (CS), a versatile biopolymer obtained through the deacetylation of chitin, has gained significant interest in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, unique gel-forming capabilities. This review comprehensively analyzes CS-based gel development, covering extraction from various natural sources, gelation mechanisms, applications. Different methods, including chemical, biological, green techniques, are discussed regarding efficiency sustainability. The explores physicochemical properties CS that influence behavior, highlighting mechanisms such as physical, ionic, chemical cross-linking. Recent advances formation, Schiff base reactions, Diels–Alder click chemistry, thermosensitive gelation, have expanded applicability hydrogels. Furthermore, gels demonstrated potential wound healing, tissue engineering, drug delivery, antimicrobial applications, offering controlled release, enhanced tunable mechanical properties. incorporation nanomaterials, bioactive molecules, functional cross-linkers further improved hydrogel performance. current underscores growing significance innovative biomaterials regenerative medicine sciences.

Language: Английский

Citations

1
A novel ratiometric NIR fluorescent probe based on tanshinone IIA with double excitation for the detection of hydrazine DOI
Linlin Chen,

Boyu Lv,

Zhonglong Wang

et al.

Dyes and Pigments, Journal Year: 2023, Volume and Issue: 220, P. 111680 - 111680

Published: Sept. 7, 2023

Language: Английский

Citations

18
Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects DOI Creative Commons
Amaal Abdulraqeb Ali, Rouba D. Al Bostami, Amani Al‐Othman

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10546 - 10559

Published: Jan. 1, 2024

Nano-based approaches, particularly nanogels, have recently emerged as a potential strategy for combating biofilm-related infections. Their exceptional characteristics including biocompatibility, biodegradability, stability, high water content, stimuli-responsiveness, and their nano size (which enables penetration into biofilms) make nanogels promising technology in the biomedical field. However, exploring biofilm treatment remains its early stages. This review examined status of application bacterial biofilms. Recent investigations studied derived from natural polymers like chitosan (CS), hyaluronic acid (HA), alginate, among others, eliminating inhibiting These were utilized carriers diverse antibiofilm agents, encompassing antibiotics, antimicrobial peptides, extracts, nanoparticles. Utilizing mechanisms conventional antibody-mediated pathways, photodynamic therapy, photothermal chemodynamic EPS degradation, these effectively administered drugs, exhibiting efficacy across several strains, notably

Language: Английский

Citations

8
Technological advancements for the management of oral biofilm DOI

Rina Rani Ray,

Smaranika Pattnaik

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 56, P. 103017 - 103017

Published: Jan. 6, 2024

Language: Английский

Citations

7
pH-responsive polymeric nanomaterials for the treatment of oral biofilm infections DOI
Geum-Jae Jeong, Muzamil Ahmad Rather, Fazlurrahman Khan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 234, P. 113727 - 113727

Published: Dec. 26, 2023

Language: Английский

Citations

16
Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention DOI Creative Commons
Qi Tong,

Qiyue Xu,

Jie Cai

et al.

MedComm – Biomaterials and Applications, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 31, 2025

Abstract At present, cardiovascular infection such as infective endocarditis (IE) has become a major disease with high mortality rate. The essence of IE is actually the associated biofilm formation, which can occur not only on native heart valves, but also prosthetic valves and implants left assist devices, vascular grafts, pacemakers. Biofilms are bacterial aggregates that composed self‐produced extracellular polymeric substance (EPS), difficult challenging for treatment infections. Therefore, it important to explore develop effective anti‐biofilm methods biofilm‐associated infection. This review provides comprehension strategies degrading EPS in biofilm, application nanodrug delivery systems biofilm‐related infections, strategy targeting drug resistance genes through gene editing technology quorum sensing biofilm. Furthermore, this some optimize antibacterial properties prevent formation. applications these will provide novel preventive therapeutic ways

Language: Английский

Citations

0