New Zealand Journal of Botany,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 85
Published: July 22, 2024
Ganoderma,
a
genus
of
mushrooms
known
for
its
long
history
medicinal
use,
has
gained
increasing
attention
in
recent
years
due
to
potential
health
benefits.
This
review
delves
into
the
bioactive
compounds
found
Ganoderma
and
elucidates
intricate
mechanisms
underlying
immunomodulatory
anti-tumour
activities.
The
diverse
health-promoting
effects
can
be
attributed
decadent
array
compounds,
notably
polysaccharides,
triterpenoids,
which
play
pivotal
role.
ability
mushroom
modulate
immune
system,
enhancing
activity
cells,
such
as
natural
killer
cells
macrophages,
is
central
focus.
Furthermore,
we
explore
how
exerts
through
induction
apoptosis,
inhibition
angiogenesis,
interference
with
various
signalling
pathways
critical
cancer
cell
growth
metastasis.
As
research
this
area
continues
evolve,
comprehensive
understanding
supplement
role
promoting
well-being
emerging,
offering
promising
avenues
further
investigation
application
healthcare.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 6, 2025
In
this
study,
Chinese
yam
polysaccharides
(CYPs)
were
fermented
using
Lactobacillus
plantarum
M616,
and
changes
in
the
chemical
composition,
structure,
anti-inflammatory
activity
of
CYPs
before
after
fermentation
investigated.
The
carbohydrate
content
L.
M616-fermented
CYP
(CYP-LP)
increased
from
71.03%
±
2.75
to
76.28%
2.37%,
whereas
protein
polyphenol
almost
unaffected
compared
with
those
unfermented
(CYP-NF).
monosaccharide
composition
CYP-NF
included
rhamnose,
arabinose,
galactose,
glucose,
mannose
a
molar
ratio
0.493:0.6695:0.9738:0.7655:12.4365.
CYP-LP
had
same
monosaccharides
as
CYP-NF,
but
was
0.3237:0.3457:0.8278:2.5541:10.4995.
Meanwhile,
molecular
weight
polydispersity
CYP-LP,
respectively,
124.774
kDa
6.58
(CYP-NF)
376.628
17.928,
indicating
low
homogeneity.
vitro
antioxidant
analysis
showed
that
M616
varying
effects
on
against
DPPH,
ABTS,
hydroxyl,
superoxide
radicals.
However,
superior
is
more
effective
regulating
dismutase,
catalase,
glutathione
peroxidase,
malondialdehyde,
nitric
oxide,
tumor
necrosis
factor-α,
interleukin-1β,
interleukin-6
release
lipopolysaccharide-induced
RAW
264.7
macrophages.
This
study
suggested
potential
ingredient
drugs
functional
food.
Small,
Journal Year:
2023,
Volume and Issue:
19(23)
Published: March 8, 2023
Cancer
immunotherapy
is
a
promising
antitumor
approach,
whereas
nontherapeutic
side
effects,
tumor
microenvironment
(TME)
intricacy,
and
low
immunogenicity
limit
its
therapeutic
efficacy.
In
recent
years,
combination
with
other
therapies
has
been
proven
to
considerably
increase
However,
achieving
codelivery
of
the
drugs
site
remains
major
challenge.
Stimulus-responsive
nanodelivery
systems
show
controlled
drug
delivery
precise
release.
Polysaccharides,
family
potential
biomaterials,
are
widely
used
in
development
stimulus-responsive
nanomedicines
due
their
unique
physicochemical
properties,
biocompatibility,
modifiability.
Here,
activity
polysaccharides
several
combined
strategies
(e.g.,
chemotherapy,
photodynamic
therapy,
or
photothermal
therapy)
summarized.
More
importantly,
progress
polysaccharide-based
for
cancer
discussed,
focus
on
construction
nanomedicine,
targeted
delivery,
release,
enhanced
effects.
Finally,
limitations
application
prospects
this
new
field
discussed.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1031 - 1031
Published: Feb. 18, 2023
Inflammatory
bowel
disease
(IBD)
is
a
chronic,
non-specific
inflammatory
of
the
intestine
that
can
be
classified
as
ulcerative
colitis
(UC)
and
Crohn's
(CD).
Currently,
incidence
IBD
still
increasing
in
developing
countries.
However,
current
treatments
for
have
limitations
do
not
fully
meet
needs
patients.
There
growing
demand
new,
safe,
highly
effective
alternative
drugs
Natural
products
(NPs)
are
used
drug
development
treatment
because
their
broad
biological
activity,
low
toxicity,
side
effects.
Numerous
studies
shown
some
NPs
strong
therapeutic
effects
on
IBD.
In
this
paper,
we
first
reviewed
pathogenesis
well
approaches
drugs.
Further,
summarized
170
different
sources
generalized
modes
action
Finally,
analyzed
potential
mechanisms
The
aim
our
review
to
provide
systematic
credible
summary,
thus
supporting
research
providing
theoretical
basis
application
functional
foods.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(31), P. 11929 - 11940
Published: Aug. 1, 2023
Dendrobium
officinale
polysaccharide
(DOP),
the
main
active
component,
has
a
variety
of
bioactivities.
In
this
study,
type
2
diabetes
mellitus
(T2DM)
and
antibiotic-induced
pseudo-germ-free
mouse
models
were
used
to
investigate
hypoglycemic
mechanisms
DOP.
The
findings
showed
that
DOP
ameliorated
dysfunctional
glucolipid
metabolism,
lipopolysaccharide
(LPS)
leakage,
metabolic
inflammation
levels
in
T2DM
mice.
Furthermore,
significantly
upregulated
mRNA
expression
tight
junction
proteins
Claudin-1,
Occludin,
ZO-1
reduced
intestinal
oxidative
stress
damage
through
LPS/TLR4/TRIF/NF-κB
axis
repair
barrier.
Interestingly,
experiments
confirmed
above
beneficial
effects
dependent
on
gut
microbiota.
16S
rRNA
analysis
strongly
inhibited
harmful
bacterium
Helicobacter
by
94.57%
facilitated
proliferation
probiotics
Allobaculum,
Bifidobacterium,
Lactobacillus
34.96,
139.41,
88.95%,
respectively.
Therefore,
is
capable
rebuilding
certain
specific
microbiota
restore
barrier
injury,
which
supports
utilization
as
new
prebiotic
functional
foods
for
T2DM.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(22), P. 4722 - 4722
Published: Nov. 8, 2023
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
It
has
been
observed
that
the
incidence
prevalence
of
IBD
are
increasing,
which
consequently
raises
risk
developing
colon
cancer.
Recently,
regulation
intestinal
barrier
by
probiotics
become
an
effective
treatment
for
colitis.
Akkermansia
muciniphila-derived
extracellular
vesicles
(Akk
EVs)
nano-vesicles
contain
multiple
bioactive
macromolecules
with
potential
to
modulate
barrier.
In
this
study,
we
used
ultrafiltration
in
conjunction
high-speed
centrifugation
extract
Akk
EVs.
A
lipopolysaccharide
(LPS)-induced
RAW264.7
cell
model
was
established
assess
anti-inflammatory
effects
found
EVs
were
able
be
absorbed
cells
significantly
reduce
expression
nitric
oxide
(NO),
TNF-α,
IL-1β
(p
<
0.05).
We
explored
preventative
on
colitis
regulating
using
mouse
caused
dextran
sulfate
sodium
(DSS).
The
findings
demonstrated
effectively
prevented
symptoms
reduced
colonic
tissue
injury.
Additionally,
enhanced
effectiveness
elevating
MUC2
(0.53
±
0.07),
improving
mucus
integrity,
reducing
permeability
Moreover,
increased
proportion
beneficial
bacteria
Firmicutes
(33.01
0.09%)
downregulated
harmful
Proteobacteria
(0.32
0.27%).
These
suggest
possess
ability
regulate
immune
responses,
protect
barriers,
gut
microbiota.
research
presents
intervention
approach
prevent
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3901 - 3915
Published: June 8, 2024
The
intestinal
mucus
barrier
is
an
important
line
of
defense
against
gut
pathogens.
Damage
to
this
brings
bacteria
into
close
contact
with
the
epithelium,
leading
inflammation.
Therefore,
its
restoration
a
promising
strategy
for
alleviating
This
study
showed
that
