Physicochemical, Carotenoid, Metabolite, and Volatile Organic Compound Profiling of Okinawan Shiikuwasha (Citrus depressa Hayata) and Calamansi (C. microcarpa Bunge) DOI Creative Commons

Moena Oe,

Yonathan Asikin,

Fumimasa Mitsube

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(15), P. 6746 - 6746

Published: Aug. 2, 2024

Shiikuwasha (Citrus depressa Hayata) and calamansi (C. microcarpa Bunge) are distinct citrus species with a strong sour taste that grow naturally in Okinawa, Japan. The present study aimed to characterize the physicochemical traits, total carotenoid content, taste/nutrient-related metabolite volatile organic compound (VOC) profiles of mature fruits from three shiikuwasha cultivation lines (“Izumi kugani”, “Izumi kugani-like”, “Ogimi kugani”) calamansi. had higher ratios soluble solids/titratable acidity but lower content than There were positive statistical correlations between carotenoids red, yellow, orange indices (a*, b*, a*/b* color spaces, respectively). Principal component analysis (PCA) revealed sucrose choline contents, while was richer sourness-related metabolites such as citrate malate. PCA plots displayed differences VOCs two cultivars, wherein accumulation much juices prepared whole edible flesh parts. also showed monoterpenes sesquiterpenes differentiated VOC This reveals flavor components cultivars highlights potential uses each local regional agro-business.

Language: Английский

Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers DOI Creative Commons
Lei Zhang, Biwei Ye, Zhuo Chen

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(3), P. 982 - 997

Published: Oct. 7, 2022

Chemotherapy is one of the important methods to treat cancer, and emergence multidrug resistance (MDR) major cause for failure cancer chemotherapy. Almost all anti-tumor drugs develop drug over a period time application in patients, reducing their effects on killing cells. Chemoresistance can lead rapid recurrence cancers ultimately patient death. MDR may be induced by multiple mechanisms, which are associated with complex process genes, factors, pathways, steps, today MDR-associated mechanisms largely unknown. In this paper, from aspects protein–protein interactions, alternative splicing (AS) pre-mRNA, non-coding RNA (ncRNA) mediation, genome mutations, variance cell functions, influence tumor microenvironment, we summarize molecular cancers. end, prospects exploration antitumor that reverse briefly discussed angle systems improved targeting properties, biocompatibility, availability, other advantages.

Language: Английский

Citations

56
Nobiletin as an inducer of programmed cell death in cancer: a review DOI
Jun Huang, Zaoshang Chang, Quzhe Lu

et al.

APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(5-6), P. 297 - 310

Published: March 21, 2022

Language: Английский

Citations

44
Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway DOI
Menglin Chen, Huai Li, Shanshan Zheng

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155360 - 155360

Published: Jan. 13, 2024

Language: Английский

Citations

8
Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives DOI

Reza Moazamiyanfar,

Sepideh Rezaei,

Hasan Aliashrafzadeh

et al.

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 29(22), P. 1713 - 1728

Published: April 27, 2023

Cancer has remained to be one of the major challenges in medicine and regarded as second leading cause death worldwide. Different types cancer may resist anti-cancer drugs following certain mutations such those tumor suppressor genes, exhaustion immune system, overexpression drug resistance mediators, which increase required concentration anticancer so overcome resistance. Moreover, treatment with a high dose is highly associated severe normal tissue toxicity. Administration low-toxic agents long been an intriguing idea enhance suppression. Naturally occurring e.g., herb-derived molecules have shown dual effect on malignant cells. On hand, these induce cell cells, while other hand reduce Nobiletin, well-known polymethoxyflavones (PMFs), reportedly various beneficial effects suppression protection cells against different toxic agents. Our review aims explain main mechanisms underlying nobiletin inhibitor cancer. We reviewed caused by nobiletin, stimulation reactive oxygen species (ROS), modulation evasion mechanisms, targeting epigenetic modulators, among others; inhibitory affecting properties hypoxia, multidrug resistance, angiogenesis, epithelial-mesenchymal transition (EMT) fully investigated. Also, inhibition anti-apoptotic invasive induced will later discussed. In end, protective cells/tissue, clinical trial results, future perspectives are reviewed.

Language: Английский

Citations

22
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress DOI
Menglin Chen, Ruijuan Zhang, Yaling Chen

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154902 - 154902

Published: May 24, 2023

Language: Английский

Citations

17
Neofunctionalization of an OMT cluster dominates polymethoxyflavone biosynthesis associated with the domestication of citrus DOI Creative Commons

Zhaoxin Peng,

Lizhi Song,

Minghua Chen

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(14)

Published: March 26, 2024

Polymethoxyflavones (PMFs) are a class of abundant specialized metabolites with remarkable anticancer properties in citrus. Multiple methoxy groups PMFs derived from methylation modification catalyzed by series hydroxylases and O -methyltransferases (OMTs). However, the specific OMTs that catalyze systematic -methylation hydroxyflavones remain largely unknown. Here, we report highly accumulated wild mandarins mandarin-derived accessions, while undetectable early-diverging citrus species related species. Our results demonstrated three homologous genes, CreOMT3 , CreOMT4 CreOMT5 crucial for PMF biosynthesis citrus, their encoded methyltransferases exhibit multisite activities hydroxyflavones, producing seven vitro vivo. Comparative genomic syntenic analyses indicated tandem may be duplicated CreOMT6 contributes to genetic basis mandarin group through neofunctionalization. We also N17 is an essential amino acid residue C3-, C5-, C6-, C3′- activity provided rationale functional deficiency OMT6 produce some domesticated A 1,041-bp deletion promoter, which found most modern cultivated mandarins, has reduced content relative early-admixture mandarins. This study provides framework reconstructing biosynthetic pathways, facilitate breeding fruits enhanced health benefits.

Language: Английский

Citations

7
Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis DOI
Bolin Zhao, Kai Liu, Xing Liu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3122 - 3145

Published: April 12, 2024

Abstract Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver injury. If left unaddressed, it will inevitably progress to the severe outcomes of cirrhosis or even hepatocellular carcinoma. In past few years, prevalence and fatality hepatic have been steadily rising on global scale. As result its intricate pathogenesis, quest for pharmacological interventions targeting has remained formidable challenge. Currently, no pharmaceuticals are exhibiting substantial clinical efficacy in management fibrosis. Hence, utmost importance expedite development novel therapeutics treatment this condition. Various research studies revealed ability different natural flavonoid compounds alleviate reverse through range mechanisms, which related regulation inflammation, oxidative stress, synthesis secretion fibrosis‐related factors, stellate cells activation, proliferation, extracellular matrix degradation these compounds. This review summarizes sources flavonoids with inhibitory effects over last decades. The anti‐fibrotic increasingly studied, making them potential source drugs due their good biosafety.

Language: Английский

Citations

6
Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice DOI Creative Commons
Zunli Ke,

Chaowen Fan,

Jun Li

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2570 - 2570

Published: March 12, 2023

Nobiletin (NOB) is a naturally occurring compound, commonly found in citrus peel, that shows hepatoprotective and lipid-reducing effects. However, the lipid biomarkers potential improvement mechanisms have not been adequately explored. Therefore, we investigated ameliorative effect molecular mechanism of NOB on NAFLD induced by high-fat diet mice. The results showed supplementation with over 12 weeks markedly improved glucose tolerance, serum profiles, inflammatory factors, hepatic steatosis, oxidative stress. These beneficial effects were mainly related to reduced levels including free fatty acids, diacylglycerols, triacylglycerols, cholesteryl esters according lipidomic analysis. Twenty lipids, DGs phosphatidylcholines, identified as biomarkers. Furthermore, RT-qPCR Western blot analysis indicated inhibited expression lipogenesis-related factors such SREBP-1c, SCD-1, FAS, upregulated oxidation (PPARα) cholesterol conversion (LXRα, CYP7A1, CYP27A1) genes well antioxidation-related (Nucl-Nrf2, NQO1, HO-1, GCLC), indicating intake may reduce biosynthesis increase consumption improve steatosis This study for understanding NAFLD.

Language: Английский

Citations

14
The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis DOI Creative Commons
Chang Gao,

Xiaodi Song,

Fanghui Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 31, 2024

Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia inflammation underlies Delaying or even blocking angiogenesis has emerged as an important target of RA treatment. Natural medicines long history treating RA, numerous reports have suggested that natural strong inhibitory activity on angiogenesis, thereby improving progression RA. could regulate following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs NF-κB PPARγ JAK2/STAT3 etc., inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, total glucoside Paeonia lactiflora Pall. Are currently most representative all products worthy development utilization. In this paper, main factors affecting were discussed different types inhibit systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming provide new perspective options for management targeting

Language: Английский

Citations

5
The role of natural products targeting macrophage polarization in sepsis-induced lung injury DOI Creative Commons

Yake Li,

Sinan Ai,

Yuan Li

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0