Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions DOI Creative Commons
Learn‐Han Lee

Progress In Microbes & Molecular Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 15, 2025

Depression affects approximately 280 million people worldwide, representing a significant public health burden. It is characterized by persistent sadness, anhedonia, fatigue, sleep disturbances, cognitive dysfunction, and in severe cases, suicidal ideation. The pathophysiology often attributed to neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis inflammation. Recently, the gut-brain has garnered attention for its role mood regulation, suggesting that probiotic supplementation may influence depressive symptoms through gut microbiome modulation. Therefore, this review examines recent findings research gaps regarding efficacy of probiotics managing clinically diagnosed depression. Emerging demonstrates daily from 3×109 CFU 9×1011 four eight weeks combination with antidepressants effective improving symptoms. Effective formulations commonly included Bifidobacteria, Lactobacilli, Lactococcus lactis, Streptococcus thermophilus. Nevertheless, remain, particularly concerning mechanistic pathways, comparative effectiveness, impact across different demographics probiotics. Furthermore, long-term effects use antidepressants, their reducing antidepressant side effects, combined psychotherapy are largely understudied. Addressing these standardized methodologies will enhance evaluations strains optimize microbiome-based treatment regimens, ultimately improve mental outcomes depression management. Graphical abstract. Summary future directions determine

Language: Английский

Gut microbiota and its metabolites in depression: from pathogenesis to treatment DOI Creative Commons
Lanxiang Liu, Haiyang Wang, Xueyi Chen

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104527 - 104527

Published: March 22, 2023

Language: Английский

Citations

306
The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components DOI Open Access
Ruo-Gu Xiong, Jiahui Li, Cheng Jin

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3258 - 3258

Published: July 23, 2023

The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention treatment strategies for disorders. Several gut microbiota, especially Firmicutes Bacteroidetes, are demonstrated affect health through microbiota-gut-brain axis, the microbiota dysbiosis can be related disorders, such as anxiety, depression, other On hand, dietary components, including probiotics Lactobacillus Bifidobacterium), prebiotics fiber alpha-lactalbumin), synbiotics, postbiotics short-chain fatty acids), dairy products, spices Zanthoxylum bungeanum, curcumin, capsaicin), fruits, vegetables, medicinal herbs, so on, could exert protective effects against by enhancing beneficial while suppressing harmful ones. In this paper, disorder-associated summarized. addition, components on targeting discussed. This paper helpful develop some natural products into pharmaceuticals functional foods prevent treat

Language: Английский

Citations

109
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis DOI Creative Commons
Chaoren Tan, Qiqi Yan, Yue Ma

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying pathophysiology of depression remain elusive. Recently, cumulate research suggests that disturbance microbiota-gut-brain axis may play vital role in etiology while correcting this could alleviate symptoms. The vagus nerve, linking brain gut through its afferent efferent branches, critical route bidirectional communication axis. Directly or indirectly, fibers can sense relay microbiota signals to induce disorders including depression. Also, changes response stress result hyperpermeability inflammation mediating by vagal efferents, which be detrimental Notably, nerve stimulation owns an anti-inflammatory effect was proved for treatment. Nevertheless, accompanied low tone, derive from contribute pathogenesis In review, we aim explore perspective axis, highlighting relationship among hyperpermeability, inflammation,

Language: Английский

Citations

60
Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis DOI Creative Commons
Vali Musazadeh, Neda Roshanravan, Parvin Dehghan

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 23, 2022

Non-alcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially developed countries; yet the approaches for preventing and treating NAFLD are not clear. This study aimed to summarize meta-analyses of randomized controlled trials that examined effects probiotics on NAFLD. We systematically searched PubMed, Scopus, Embase, Web Science, Cochrane Central Library databases up August 2021. All Meta-analysis studies assessing effect function tests [alanine aminotransferase (ALT), aspartate (AST), Gamma-glutamyl transferase (GGT)] were included. was conducted using a random-effects model. Sensitivity subgroup analyses also performed. The umbrella covered ten eligible involving 5,162 individuals. Beneficial supplementation revealed ALT (ES = −10.54 IU/L; 95% CI: −12.70, −8.39; p < 0.001; I 2 60.9%, 0.006), AST −10.19 IU/L, 95%CI: −13.08, −7.29, 79.8%, 0.001), GGT −5.88 −7.09, −4.67, 0.009; 0.0%, 0.591) levels. Probiotics have ameliorating ALT, AST, levels patients with Overall, could be recommended as an adjuvant therapeutic method management

Language: Английский

Citations

40
A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression DOI Open Access
Dinyadarshini Johnson, Vengadesh Letchumanan, C. Thum

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1382 - 1382

Published: March 13, 2023

Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents key domain healthcare, which has limited, adverse-effect prone treatment options, probiotics may hold be novel, customizable for depression. Clinical depression is common, potentially debilitating condition that amenable precision psychiatry-based approach utilizing probiotics. Although our understanding not yet reached sufficient level, this could therapeutic can tailored specific individuals with own unique set characteristics issues. Scientifically, use as valid basis rooted in microbiota-gut-brain axis (MGBA) mechanisms, play role pathophysiology theory, appear ideal adjunct therapeutics major depressive disorder (MDD) stand-alone mild MDD revolutionize disorders. there wide range an almost limitless combinations, review aims narrow focus most widely commercialized studied strains, namely Lactobacillus Bifidobacterium, bring together arguments usage patients (MDD). Clinicians, scientists, industrialists critical stakeholders exploring groundbreaking concept.

Language: Английский

Citations

36
The Role of Probiotics and Their Metabolites in the Treatment of Depression DOI Creative Commons
Monika Elżbieta Jach, Anna Serefko, Aleksandra Szopa

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3213 - 3213

Published: April 4, 2023

Depression is a common and complex mental emotional disorder that causes disability, morbidity, quite often mortality around the world. closely related to several physical metabolic conditions causing depression. Studies have indicated there relationship between intestinal microbiota brain, known as gut–brain axis. While this microbiota–gut–brain connection disturbed, dysfunctions of immune system, endocrine gastrointestinal tract occur. Numerous studies show dysbiosis characterized by abnormal dysfunction axis could be direct cause disorders. Traditional treatment depression includes psychotherapy pharmacotherapy, it mainly targets brain. However, restoration functions via using probiotics, their metabolites, prebiotics, healthy diet may alleviate depressive symptoms. Administration probiotics labeled psychobiotics metabolites metabiotics, especially an adjuvant antidepressants, improves It new approach prevention, management, illnesses, particularly major For effectiveness antidepressant therapy, should administered at dose higher than 1 billion CFU/day for least 8 weeks.

Language: Английский

Citations

33
Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation DOI Creative Commons
Xin Qian, Qing Li,

Huiyue Zhu

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101798 - 101798

Published: Oct. 30, 2024

Language: Английский

Citations

16
Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials DOI Open Access
Freiser Eceomo Cruz Mosquera,

Santiago Lizcano Martinez,

Yamil Liscano

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1352 - 1352

Published: April 30, 2024

In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management

Language: Английский

Citations

14
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights DOI
Fatemeh Taghizadeh Ghassab,

Fatemeh Shamlou Mahmoudi,

Reyhaneh Taheri Tinjani

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122748 - 122748

Published: June 5, 2024

Language: Английский

Citations

10
Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy DOI Creative Commons
Rebecca F. Slykerman, Naomi Davies, Klára Vlčková

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

Citations

2