The 16p11.2 microdeletion influences how early-life microbiota perturbations affect hippocampal development and behavior throughout the lifespan DOI Creative Commons
Courtney McDermott, Zhan Gao,

Anya S. Mirmajlesi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Neurodevelopmental disorders result from interactions between genetic predisposition and environmental risk factors, with infancy being the most vulnerable period. We designed a longitudinal study to determine how short-term antibiotic exposure during early postnatal life impacts gut microbiome, neurodevelopment, behavior, whether these alterations were exacerbated by neurodevelopmental disorder-associated 16p11.2 microdeletion (16pDel) mutation. The cephalosporin antibiotic, cefdinir, broadly altered microbiome acutely, persistent reductions in several Lachnospiraceae genera despite overall recovery. These preceded long-term behavioral changes, including reduced juvenile sociability, compromised assessment, deficits associative learning. Remarkably, only cefdinir-exposed 16pDel mice had changes hippocampal stem cell proliferation, subsequent adolescent numbers, gene expression compared other groups, demonstrating that can modulate effects of early-life on neurodevelopment. may be mediated gastrointestinal disturbances, as males increased intestinal permeability shifted metabolite profiles arginine biosynthesis glycerophospholipid metabolism. Taken together, this highlights microbial affect behavior reveals influences antibiotic-induced development. Further, insights identify metabolic mechanisms potential targets for intervention raise concerns regarding use infancy.

Language: Английский

Metabolite profiling of human‐originated Lachnospiraceae at the strain level DOI Creative Commons
Rashidin Abdugheni,

Wen‐Zhao Wang,

Yujing Wang

et al.

iMeta, Journal Year: 2022, Volume and Issue: 1(4)

Published: Oct. 13, 2022

Abstract The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of most abundant widely occurring bacterial groups in GI tract. Beneficial adverse effects on host health were reported, but diversities at species/strain levels as well their metabolites have been, so far, not documented. In present study, we report collection 77 h uman‐originated L a ch nospiraceae sp ecies (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae ) vitro metabolite profiles 110 strains ( https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites ). hLchsp produced 242 17 categories. larger categories alcohols (89), ketones (35), pyrazines (29), short (C2–C5), long (C > 5) chain acids (31), phenols (14), aldehydes other 30 compounds. Among them, 22 aromatic well‐known beneficial gut microbial metabolite, butyric acid, was generally by many strains, Agathobacter rectalis strain Lach‐101 Coprococcus comes NSJ‐173 top 2 acid producers, 331.5 310.9 mg/L vitro, respectively. Further analysis publicly available cohort‐based volatile‐metabolomic data sets feces revealed that over 30% prevailing volatile covered identified this study. This study provides resources together with metabolic for future studies host–microbe interactions developments novel probiotics or biotherapies.

Language: Английский

Citations

95
The human gut microbiome and aging DOI Creative Commons
Evan S. Bradley, John P. Haran

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 3, 2024

The composition of the human gut microbiome has been observed to change over course an individual's life. From birth, it is shaped by mode delivery, diet, environmental exposures, geographic location, exposures medications, and aging itself. Here, we present a narrative review across lifespan with focus on its impacts age-related diseases in humans. We will describe how shaped, features that have associated at different phases life this can adversely affect healthy aging. Across lifespan, especially old age, diverse includes organisms suspected produce anti-inflammatory metabolites such as short-chain fatty acids, reported be These findings remarkably consistent regions world suggesting they could universal all cultures genetic backgrounds. Exactly these biologic processes thus promoting crucial targeting for interventions support health longevity.

Language: Английский

Citations

20
Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior DOI Creative Commons
Claudia M. Di Gesù, Lisa M. Matz,

Ian J. Bolding

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 41(2), P. 111461 - 111461

Published: Oct. 1, 2022

Dysbiosis of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. We previously showed that high-fat diet (MHFD) in mice induces dysbiosis, social dysfunction, and underlying synaptic plasticity deficits male offspring (F1). Here, we reason that, if HFD-mediated changes microbiota drive deficits, then MHFD-induced dysbiosis F1 female MHFD would likewise impair F2 behavior. Metataxonomic sequencing reveals reduced microbial richness among offspring. Despite recovery MHFD-descendant mice, they display dysfunction. Post-weaning Limosilactobacillus reuteri treatment increases abundance short-chain fatty acid-producing taxa rescues deficits. L. exerts a sexually dimorphic impact on configuration, increasing discriminant between cohorts. Collectively, these results show multigenerational impacts HFD-induced lineage highlight potential microbiome-targeted interventions for disorders.

Language: Английский

Citations

43
Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior DOI
Carolina de Weerth, Anna‐Katariina Aatsinki, Meghan B. Azad

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(26), P. 7945 - 7982

Published: March 30, 2022

Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond documented positive effects of breastfeeding on infant and maternal health, there increasing evidence that constituents also impact child neurodevelopment. Non-nutrient bioactives would contribute the (long-term) development cognition behavior, process termed 'Lactocrine Programming'. In this review we discuss current state field human composition its links with cognitive behavioral development. To promote state-of-the-art methodologies designs facilitate data pooling meta-analytic endeavors, present detailed recommendations best practices for future studies. Finally, determine important scientific gaps need be filled advance field, innovative directions research. Unveiling mechanisms underlying between behavior will deepen our understanding broad functions food, as well provide necessary information designing interventions.

Language: Английский

Citations

42
Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus) DOI

Qingzhi Zheng,

Lihua Cui,

Hongping Liao

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 891, P. 164319 - 164319

Published: May 24, 2023

Language: Английский

Citations

37
The Gut Microbiome in the First One Thousand Days of Neurodevelopment: A Systematic Review from the Microbiome Perspective DOI Creative Commons
Nathalia Ferrazzo Naspolini, Paulo Alfonso Schüroff, Maria José Figueiredo

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 424 - 424

Published: Feb. 20, 2024

Evidence shows that the gut microbiome in early life is an essential modulator of physiological processes related to healthy brain development, as well mental and neurodegenerative disorders. Here, we conduct a systematic review assessments on infants (both with conditions affect development) during first thousand days life, associated neurodevelopmental outcomes, aim investigating key players mechanisms through which affects brain. Bacteroides Bifidobacterium were non-social fear behavior, duration orientation, cognitive motricity neurotypical development. Lachnospiraceae, Streptococcus, Faecalibacterium showed variable levels influence behavior Few studies described mechanistic insights NAD salvage, aspartate asparagine biosynthesis, methanogenesis, pathways involved bile acid transformation, short-chain fatty acids production, microbial virulence genes. Further associating species gene robustness data analysis integration are required elucidate functional underlying role microbiome–gut–brain axis

Language: Английский

Citations

11
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria DOI Creative Commons

Diana Ćesić,

Liborija Lugović‐Mihić, Petar Ozretić

et al.

Life, Journal Year: 2023, Volume and Issue: 13(6), P. 1280 - 1280

Published: May 30, 2023

(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of gut microbiota. Furthermore, various studies have highlighted anti-inflammatory properties short-chain fatty acids (SCFAs), whose production is primarily regulated by However, only a few investigated role major SCFA producers, such as

Language: Английский

Citations

22
Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice DOI Creative Commons
Yinhu Li, Yijing Chen, Yingying Fan

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 1, 2023

The intimate association between the gut microbiota (GM) and central nervous system points to potential intervention strategies for neurological diseases. Nevertheless, there is currently no theoretical framework selecting window period target bacteria GM interventions owing complexity of microecosystem. In this study, we constructed a complex network-based modeling approach evaluate topological features infer bacterial candidates interventions. We used Alzheimer's disease (AD) as an example traced dynamic changes in AD wild-type mice at one, two, three, six, nine months age. results revealed alterations from scale-free network into random during progression, indicating severe disequilibrium late stage AD. Through stability vulnerability assessments networks, identified third month after birth optimal mice. Further computational simulations robustness evaluations determined that hub were Moreover, our functional analysis suggested Lachnospiraceae UCG-001 – enriched bacterium was keystone its contributions quinolinic acid synthesis. conclusion, study established practical strategy perspective

Language: Английский

Citations

19
Morin alleviates DSS-induced ulcerative colitis in mice via inhibition of inflammation and modulation of intestinal microbiota DOI Creative Commons
Li Qiu,

Chengqiu Yan,

Yue Yang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112846 - 112846

Published: Aug. 8, 2024

Ulcerative colitis (UC) is a chronic inflammatory condition with recurrent and challenging symptoms. Effective treatments are lacking, making UC management critical research area. Morin (MO), flavonoid from the Moraceae family, shows potential as an anti-UC agent, but its mechanisms not fully understood. Using dextran sulfate sodium (DSS)-induced mouse model, we employed network pharmacology to predict MO's therapeutic effects. Assessments included changes in body weight, disease activity index (DAI), colon length. Immunofluorescence, hematoxylin eosin (H&E), PAS staining evaluated damage. ELISA western blot analyzed factors, tight junction (TJ)-associated proteins (Claudin-3, Occludin, ZO-1), Mitogen-Activated Protein Kinase (MAPK)/ Nuclear Factor kappa B (NF-κB) pathways. 16S rRNA sequencing assessed gut microbiota diversity, confirmed by modulation via Fecal Microbial Transplantation (FMT). Early MO intervention reduced severity improving DAI scores, length, increasing goblet cells, enhancing barrier function, inhibiting MAPK/NF-κB enriched microbiota, favoring beneficial bacteria like Muribaculaceae Erysipelotrichaceae while reducing harmful Muribaculaceae. This study highlights through inflammation control, mucosal integrity maintenance, flora modulation.

Language: Английский

Citations

6
A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice DOI
Jiahui Zhao, Rongjun He,

Hao Zhong

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124291 - 124291

Published: April 5, 2023

Language: Английский

Citations

15