Brain Structure and Function, Journal Year: 2024, Volume and Issue: 230(1)
Published: Dec. 17, 2024
Language: Английский
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)
Published: Feb. 1, 2024
Amyotrophic lateral sclerosis (ALS) is a progressive motor and extra-motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers neuropsychological assessments of the hippocampal parahippocampal regions in patients with ALS.
Language: Английский
Citations
13
Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 1815 - 1833
Published: Feb. 29, 2024
Language: Английский
Citations
13
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e27950 - e27950
Published: March 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Language: Английский
Citations
10
Journal of Medical Radiation Sciences, Journal Year: 2023, Volume and Issue: 71(1), P. 133 - 141
Published: Aug. 10, 2023
Despite improvements in imaging and treatment approaches, brain metastases (BMs) continue to be the primary cause of mortality morbidity about 20% adult cancer patients. This research aimed review magnetic resonance (MRI) clinical characteristics BMs resulting from breast (BC). A systematic original articles published January 2000 June 2023. We selected studies that reported MRI findings BC excluded reviews, case reports, books/book chapters, animal irrelevant records. identified 24 included 1580 patients with BMs. T1-weighted (T1-w) (pre- postcontrast), T2-weighted (T2-w), fluid-attenuated inversion recovery (FLAIR) T2*-weighted (T2*-w) was used measure lesion size, shape area. In other studies, advanced structural techniques including diffusion-weighted (DWI), diffusion tensor (DTI) susceptibility-weighted (SWI) were more precisely sensitively evaluate pathological Furthermore, functional metabolic like (fMRI), spectroscopy (MRS) perfusion-weighted (PWI) have also been utilised. The varied depending on technique, subtype, size shape, presence haemorrhage or necrosis comparison tumours. Some associated prognosis, recurrence cognitive impairment detects, characterises monitors BC. Findings vary by More should validate emerging techniques, determine implications explore underlying mechanisms biology is a valuable tool for diagnosis, targeted therapy studying metastasis.
Language: Английский
Citations
18
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Sept. 27, 2023
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that can measure the of tissues, which reflect their iron content. QSM has been used to detect accumulation in cortical and subcortical brain regions. However, its application regions such as basal ganglia, particularly putamen, rare patients with amyotrophic lateral sclerosis (ALS).We present case 40-year-old male patient ALS who underwent an MRI for QSM. We compared his images those control subject performed quantitative analysis values putamen also reviewed literature on previous studies summarized methods findings. Our revealed increased bilateral controls, indicating overload. This finding consistent reporting dysregulation nuclei ALS. discussed processing techniques our study literature, highlighting advantages limitations.This report demonstrates potential sensitive biomarker evaluating levels patients. provide information deposition patterns both motor extra-motor areas patients, may help understand pathophysiology monitor disease progression. Further larger samples are needed validate these results explore clinical implications
Language: Английский
Citations
16
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: July 3, 2024
: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).
Language: Английский
Citations
7
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 77 - 77
Published: April 10, 2024
Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders characterized by motor impairment and non-motor symptoms. The involvement of the thalamus in MNDs, especially conditions such as amyotrophic lateral sclerosis (ALS), its interaction with frontotemporal dementia (FTD), has garnered increasing research interest. This systematic review analyzed magnetic resonance imaging (MRI) studies that focused on thalamic alterations MNDs to understand significance these changes their correlation clinical outcomes. Methods: Following PRISMA 2020 guidelines, PubMed Scopus databases were searched from inception June 2023 for related MRI findings patients MNDs. Eligible included adult diagnosed ALS or other forms MND who underwent brain MRI, outcomes alterations. Studies evaluated risk bias using Newcastle-Ottawa scale. Results: A total 52 (including 3009 2181 healthy controls) used various techniques, including volumetric analysis, diffusion tensor imaging, functional measure volume, connectivity, confirmed significant atrophy microstructural degradation, which associated disease severity, progression, disability. Thalamic varies across different subtypes is influenced presence cognitive mutations genes chromosome 9 open reading frame 72 (C9orf72). synthesis indicates pathology a prevalent early biomarker contributes deficits. promising target monitoring dysfunction underpins variety symptoms Conclusions: provide valuable insights into pathophysiology progression Multimodal techniques potent tools detecting dynamic changes, indicating structural integrity, connectivity disruption, metabolic activity.
Language: Английский
Citations
6
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)
Published: June 1, 2024
Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as disease (MND), ALS also affects non-motor regions, such the hypothalamus. This study aimed to quantify hypothalamic subregion volumes in patients with versus healthy controls (HCs) examine their associations demographic clinical features.
Language: Английский
Citations
6
Acta Neurologica Scandinavica, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 14
Published: Aug. 31, 2023
Motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS) are progressive neurodegenerative disorders affecting upper and lower motor neurons (UMN LMN). Magnetic resonance imaging (MRI) often reveals a “motor band sign” (MBS) of hypointensity along the precentral gyri in ALS, considered radiologic hallmark. This review comprehensively summarizes literature on MBS ALS related MNDs using multiple MRI techniques. A systematic search was conducted PubMed Scopus databases to identify relevant studies published until August 2023. Twelve were included. Most patients had UMN involvement at onset. correlated with impairment severity. Susceptibility-weighted (SWI) detected majority MND patients. The use SWI could be particularly useful detecting MBS, it should as part routine clinical protocols. Recent suggest that atrophy primary cortex (M1) nearby regions can used markers MNDs. Other techniques T2-weighted (T2-w), T2 -w, fluid-attenuated inversion recovery (FLAIR) also showed characteristic changes. Furthermore, quantitative susceptibility mapping (QSM) is an advanced technique allows sensitive quantification iron deposition has shown promise for accurately findings MR neuroimaging provide valuable insights into pathophysiology detect biomarkers such MBS. demonstrates cortical white matter changes reflecting degeneration ALS. To find out how suggestive movement well works prognostic indicator, we will need do more research combines comprehensive prospective longitudinal research.
Language: Английский
Citations
15
Neurology, Journal Year: 2024, Volume and Issue: 103(2)
Published: June 14, 2024
Dysfunction of energy metabolism, cognition, and behavior are important nonmotor symptoms amyotrophic lateral sclerosis (ALS), negatively affecting survival quality life, but poorly understood. Neuroimaging is ideally suited to studying neurodegeneration in ALS, few studies have focused on the hypothalamus, a key region for regulating homeostasis, behavior. We evaluated, therefore, hypothalamic ALS explored relationship between volumes dysregulation cognitive behavioral changes, disease progression, survival.
Language: Английский
Citations
5