Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108691 - 108691
Published: Dec. 16, 2024
Language: Английский
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)
Published: Feb. 1, 2024
Amyotrophic lateral sclerosis (ALS) is a progressive motor and extra-motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers neuropsychological assessments of the hippocampal parahippocampal regions in patients with ALS.
Language: Английский
Citations
13
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Feb. 26, 2024
Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use quantitative susceptibility mapping (QSM) to detect accumulation in deep gray matter (DGM) basal ganglia AD, contributing a better understanding AD progression, potentially leading new diagnostic therapeutic approaches. Methods Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web Sciences, Google Scholar databases up October 2023 studies employing QSM research. Eligibility criteria were based on PECO framework, included assessing alterations magnetic indicative DGM patients with AD. After initial screening quality assessment using Newcastle-Ottawa Scale, was conducted compare levels between healthy controls (HCs) random-effects model. Results The nine comprising 267 272 HCs. There significantly higher values, indicating greater deposition, putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 1.84; p 0.00), globus pallidus (SMD 0.79; 0.07 1.52; 0.03), caudate nucleus 0.72; 0.39 1.06; 0.00) compared However, no significant differences found thalamus 1.00; −0.42 2.43; 0.17). sensitivity analysis indicated that single study impacted overall results. Age identified major contributor heterogeneity across all nuclei subgroup analysis. Older age (>69 years) lower male percentage (≤30%) associated increase Conclusion suggests excessive deposition is linked especially putamen. underscores complex nature pathology iron, influenced age, sex, regional differences, necessitating further research comprehensive understanding.
Language: Английский
Citations
11
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e27950 - e27950
Published: March 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Language: Английский
Citations
10
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: July 3, 2024
: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).
Language: Английский
Citations
7
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 77 - 77
Published: April 10, 2024
Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders characterized by motor impairment and non-motor symptoms. The involvement of the thalamus in MNDs, especially conditions such as amyotrophic lateral sclerosis (ALS), its interaction with frontotemporal dementia (FTD), has garnered increasing research interest. This systematic review analyzed magnetic resonance imaging (MRI) studies that focused on thalamic alterations MNDs to understand significance these changes their correlation clinical outcomes. Methods: Following PRISMA 2020 guidelines, PubMed Scopus databases were searched from inception June 2023 for related MRI findings patients MNDs. Eligible included adult diagnosed ALS or other forms MND who underwent brain MRI, outcomes alterations. Studies evaluated risk bias using Newcastle-Ottawa scale. Results: A total 52 (including 3009 2181 healthy controls) used various techniques, including volumetric analysis, diffusion tensor imaging, functional measure volume, connectivity, confirmed significant atrophy microstructural degradation, which associated disease severity, progression, disability. Thalamic varies across different subtypes is influenced presence cognitive mutations genes chromosome 9 open reading frame 72 (C9orf72). synthesis indicates pathology a prevalent early biomarker contributes deficits. promising target monitoring dysfunction underpins variety symptoms Conclusions: provide valuable insights into pathophysiology progression Multimodal techniques potent tools detecting dynamic changes, indicating structural integrity, connectivity disruption, metabolic activity.
Language: Английский
Citations
6
Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1211 - 1211
Published: March 8, 2025
Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.
Language: Английский
Citations
0
Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 18(5), P. 1239 - 1255
Published: May 17, 2024
Language: Английский
Citations
3
Aging Medicine, Journal Year: 2024, Volume and Issue: 7(5), P. 649 - 667
Published: Oct. 1, 2024
Abstract Alzheimer's disease (AD) is a neurodegenerative that characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral body iron dysregulation accumulation interact with AD pathology, particularly in the precuneus, crucial functional hub cognitive functions. Quantitative susceptibility mapping (QSM), novel post‐processing approach, provides insights into tissue levels oxygen metabolism reveals abnormal early AD. Increased deposition precuneus can lead to oxidative stress, neuroinflammation, accelerated neurodegeneration. Metabolic disorders (diabetes, non‐alcoholic fatty liver (NAFLD), obesity), genetic factors, small vessel pathology contribute precuneus. Therefore, line growing of literature region patients AD, QSM as neuroimaging method could serve non‐invasive biomarker track progression, complement other imaging modalities, aid diagnosis monitoring.
Language: Английский
Citations
3
iRadiology, Journal Year: 2024, Volume and Issue: 2(4), P. 387 - 395
Published: June 7, 2024
Abstract Quantitative susceptibility mapping (QSM) is an advanced post‐processing technique in magnetic resonance imaging that offers precise measurements of tissue with impressive spatial resolution and sensitivity. This review examines the potential QSM as a biomarker for early detection monitoring amyotrophic lateral sclerosis (ALS). Since 2015, studies have consistently reported increased values motor regions individuals ALS, indicating significant iron deposition. Iron accumulation associated dysfunction upper neurons faster disease progression. Notably, were also observed critical subcortical areas responsible function cognitive control. However, standardizing optimized protocols, including background field removal algorithms, phase unwrapping approaches, methods final map reconstruction, has to enhance consistency reliability ALS biomarker. Overall, current body evidence strongly supports detecting dysregulation neurodegeneration both extra‐motor ALS. Furthermore, QSM's remarkable sensitivity pathological changes its high specificity distinguishing positions make it promising diagnostic progression‐tracking
Language: Английский
Citations
2
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 86(3), P. 1584 - 1589
Published: Feb. 8, 2024
Long-term or post-COVID-19 syndrome (PCS) is a condition that affects people infected with SARS‑CoV‑2, the virus causes COVID-19. PCS characterized by wide range of persistent new symptoms last months after initial infection, such as fatigue, shortness breath, cognitive dysfunction, and pain. Advanced magnetic resonance (MR) neuroimaging techniques can provide valuable information on structural functional changes in brain associated well potential biomarkers for diagnosis prognosis. In this review, we discuss feasibility applications various advanced MR PCS, including perfusion-weighted imaging (PWI), diffusion-weighted (DWI), susceptibility-weighted (SWI), (fMRI), diffusion tensor (DTI), tractography. We summarize current evidence findings challenges limitations these techniques, future directions research clinical practice. Although still uncertain, MRI show promise gaining insight into pathophysiology guiding management COVID-19 syndrome, pending larger validation studies.
Language: Английский
Citations
1