Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108691 - 108691
Published: Dec. 16, 2024
Language: Английский
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)
Published: Feb. 1, 2024
Amyotrophic lateral sclerosis (ALS) is a progressive motor and extra-motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers neuropsychological assessments of the hippocampal parahippocampal regions in patients with ALS.
Language: Английский
Citations
13
Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 1815 - 1833
Published: Feb. 29, 2024
Language: Английский
Citations
13
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Feb. 26, 2024
Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use quantitative susceptibility mapping (QSM) to detect accumulation in deep gray matter (DGM) basal ganglia AD, contributing a better understanding AD progression, potentially leading new diagnostic therapeutic approaches. Methods Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web Sciences, Google Scholar databases up October 2023 studies employing QSM research. Eligibility criteria were based on PECO framework, included assessing alterations magnetic indicative DGM patients with AD. After initial screening quality assessment using Newcastle-Ottawa Scale, was conducted compare levels between healthy controls (HCs) random-effects model. Results The nine comprising 267 272 HCs. There significantly higher values, indicating greater deposition, putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 1.84; p 0.00), globus pallidus (SMD 0.79; 0.07 1.52; 0.03), caudate nucleus 0.72; 0.39 1.06; 0.00) compared However, no significant differences found thalamus 1.00; −0.42 2.43; 0.17). sensitivity analysis indicated that single study impacted overall results. Age identified major contributor heterogeneity across all nuclei subgroup analysis. Older age (>69 years) lower male percentage (≤30%) associated increase Conclusion suggests excessive deposition is linked especially putamen. underscores complex nature pathology iron, influenced age, sex, regional differences, necessitating further research comprehensive understanding.
Language: Английский
Citations
11
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e27950 - e27950
Published: March 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Language: Английский
Citations
10
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Sept. 27, 2023
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that can measure the of tissues, which reflect their iron content. QSM has been used to detect accumulation in cortical and subcortical brain regions. However, its application regions such as basal ganglia, particularly putamen, rare patients with amyotrophic lateral sclerosis (ALS).We present case 40-year-old male patient ALS who underwent an MRI for QSM. We compared his images those control subject performed quantitative analysis values putamen also reviewed literature on previous studies summarized methods findings. Our revealed increased bilateral controls, indicating overload. This finding consistent reporting dysregulation nuclei ALS. discussed processing techniques our study literature, highlighting advantages limitations.This report demonstrates potential sensitive biomarker evaluating levels patients. provide information deposition patterns both motor extra-motor areas patients, may help understand pathophysiology monitor disease progression. Further larger samples are needed validate these results explore clinical implications
Language: Английский
Citations
16
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 77 - 77
Published: April 10, 2024
Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders characterized by motor impairment and non-motor symptoms. The involvement of the thalamus in MNDs, especially conditions such as amyotrophic lateral sclerosis (ALS), its interaction with frontotemporal dementia (FTD), has garnered increasing research interest. This systematic review analyzed magnetic resonance imaging (MRI) studies that focused on thalamic alterations MNDs to understand significance these changes their correlation clinical outcomes. Methods: Following PRISMA 2020 guidelines, PubMed Scopus databases were searched from inception June 2023 for related MRI findings patients MNDs. Eligible included adult diagnosed ALS or other forms MND who underwent brain MRI, outcomes alterations. Studies evaluated risk bias using Newcastle-Ottawa scale. Results: A total 52 (including 3009 2181 healthy controls) used various techniques, including volumetric analysis, diffusion tensor imaging, functional measure volume, connectivity, confirmed significant atrophy microstructural degradation, which associated disease severity, progression, disability. Thalamic varies across different subtypes is influenced presence cognitive mutations genes chromosome 9 open reading frame 72 (C9orf72). synthesis indicates pathology a prevalent early biomarker contributes deficits. promising target monitoring dysfunction underpins variety symptoms Conclusions: provide valuable insights into pathophysiology progression Multimodal techniques potent tools detecting dynamic changes, indicating structural integrity, connectivity disruption, metabolic activity.
Language: Английский
Citations
6
Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 18(5), P. 1239 - 1255
Published: May 17, 2024
Language: Английский
Citations
3
iRadiology, Journal Year: 2024, Volume and Issue: 2(4), P. 387 - 395
Published: June 7, 2024
Abstract Quantitative susceptibility mapping (QSM) is an advanced post‐processing technique in magnetic resonance imaging that offers precise measurements of tissue with impressive spatial resolution and sensitivity. This review examines the potential QSM as a biomarker for early detection monitoring amyotrophic lateral sclerosis (ALS). Since 2015, studies have consistently reported increased values motor regions individuals ALS, indicating significant iron deposition. Iron accumulation associated dysfunction upper neurons faster disease progression. Notably, were also observed critical subcortical areas responsible function cognitive control. However, standardizing optimized protocols, including background field removal algorithms, phase unwrapping approaches, methods final map reconstruction, has to enhance consistency reliability ALS biomarker. Overall, current body evidence strongly supports detecting dysregulation neurodegeneration both extra‐motor ALS. Furthermore, QSM's remarkable sensitivity pathological changes its high specificity distinguishing positions make it promising diagnostic progression‐tracking
Language: Английский
Citations
2
iRadiology, Journal Year: 2023, Volume and Issue: 1(4), P. 378 - 380
Published: Nov. 21, 2023
Motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), are a group of devastating and progressive neurodegenerative disorders that affect the upper lower motor neurons (UMN LMN) [1]. Other forms MND include primary (PLS), muscular atrophy, bulbar palsy, spinal frontotemporal dementia-MND [2]. Early accurate diagnosis is critical; yet prognosis MNDs challenging due to complexity heterogeneity these diseases. Therefore, there need for sensitive, suggestive, reliable biomarkers detect monitor progression neurodegeneration neuroinflammation in The band sign (MBS), described curvilinear "band" hypointensity precentral gyrus (and cortex [M1 area]) susceptibility-weighted images generated from gradient-echo pulse sequences (GRE/SWI) or GRE-T2*-weighted image, considered magnetic resonance imaging (MRI) biomarker UMN involvement MNDs, ALS PLS (Figure 1) [1, 3]. sensitivity SWI particularly high when it comes detecting deoxygenated blood mineral deposits within brain [4]. MBS has also been observed other movement 5, 6], Parkinson's disease [5-7], Alzhimer's [5-8], Huntington's [9]. Symmetric (white arrows) along central sulcus, layering bilaterally (adapted Mohammadi & Ghaderi [1] Copyright © 2023 Sana Sadegh Ghaderi. This an open access article distributed under Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.). exact cause not fully comprehended, but widely believed result accumulation iron degeneration microglia suspected basis increased cortical deposition microglial activity regions supported by neuroimaging neuropathological studies [10]. (2023) provide comprehensive review literature growing body evidence supporting utility MRI characteristic changes with focus on study found presence MBS, area gyri, linked severity impairment patients MNDs. highlighted strong association between builds previous demonstrating specificity compared healthy controls [3]. Quantitative techniques like quantitative susceptibility mapping (QSM) allow sensitive quantification have shown promise accurately Compared conventional techniques, T2-weighted (T2-w), T2*-w, R2* relaxation, including QSM offers superior As mentioned studies, extent hypointensities correlates over time [3, 4]. Together, findings strongly support use metrics both research clinical settings. Given lack diagnostic prognostic diseases, optimizing protocols and/or could valuable insights into pathophysiology progression. suggested [1], SWI/QSM should prompt close monitoring emerging MND. MR indicators closely reflect can serve outcome measures trials These collective advocate inclusion routine protocols. detection advanced SWI/QSM, shows great objective marker potential significantly impact prognosis, diagnosis, treatment this critically underserved patient population. concept hallmark gaining acceptance, adoption recommended capitalize insights. For maximum utility, further larger prospective cohorts needed determine sensitivity, specificity, predictive values across various subtypes different stages disease. Longitudinal multicenter track correlation will help establish values. In addition, multimodal combining structural, functional, metabolic, may offer best though optimization feasible needed. analyzed data prepared first draft manuscript. participated conception design study; constructively revised manuscript; collection organization; supervised throughout, they share corresponding authorship. All authors commented versions manuscript approved final version. None. declare no conflict interest. Not applicable. available request author. publicly privacy ethical restrictions.
Language: Английский
Citations
4
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: July 22, 2024
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Biomarkers are needed to improve diagnosis, gauge progression, evaluate treatment. Diffusion tensor imaging (DTI) promising biomarker for detecting microstructural alterations in the white matter tracts. This study aimed assess DTI metrics as biomarkers examine their relationship with clinical assessments patients ALS. Eleven ALS 21 healthy controls (HCs) underwent 3T MRI DTI. metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial (RD), axial (AD), were compared between key extra-motor tract groups. Group comparisons correlations also correlated scores disability (ALSFRS-R), muscle strength (dynamometry), unit (MUNIX). Widespread differences found HCs decreased FA increased metrics. However, MD RD more sensitive changes Significant interhemispheric observed. showed symmetry hemispheres assessments. MD, RD, AD increases significantly ALSFRS-R MUNIX weaker dynamometry results. reveals damage along regions patients. can serve quantitative neuroimaging prognosis, monitoring Combined analysis imaging, electrodiagnostic, functional shows potential characterizing pathophysiology progression.
Language: Английский
Citations
1