IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
We
have
focused
on
nanoparticles(NPs)-based
biosensors
to
detect
various
biomarkers,
including
pathogens
in
saliva,
for
the
determination
of
disease
activities
dentistry.
Recently,
NPs-based
studies
related
dentistry
research
been
receiving
growing
interest
from
researchers.
The
NPs
potential
give
rapid
and
efficient
responses
detection
targets
owing
their
unique
enhanced
physico-chemical
biological
properties.
discussed
consisting
plasmonic
(silver,
gold
NPs,
etc.),
metallic
(quantum
dots,
carbon
family
(graphene
oxide,
single-walled
nanotubes,
multi-walled
hybrid
NPs.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
194, P. 114708 - 114708
Published: Jan. 20, 2023
The
objective
of
this
manuscript
is
to
provide
quantitative
insights
into
the
tissue
distribution
nanoparticles.
Published
pharmacokinetics
nanoparticles
in
plasma,
tumor
and
13
different
tissues
mice
were
collected
from
literature.
A
total
2018
datasets
analyzed
biodistribution
graphene
oxide,
lipid,
polymeric,
silica,
iron
oxide
gold
was
quantitatively
characterized
using
Nanoparticle
Biodistribution
Coefficients
(NBC).
It
observed
that
typically
after
intravenous
administration
most
are
accumulated
liver
(NBC
=
17.56
%ID/g)
spleen
12.1
%ID/g),
while
other
received
less
than
5
%ID/g.
NBC
values
for
kidney,
lungs,
heart,
bones,
brain,
stomach,
intestine,
pancreas,
skin,
muscle
found
be
3.1
%ID/g,
2.8
1.8
0.9
0.3
1.2
1.0
0.6
%ID/g
3.4
respectively.
Significant
variability
nanoparticle
certain
organs
such
as
liver,
lungs.
large
fraction
could
explained
by
accounting
differences
physicochemical
properties
size
material.
critical
overview
published
physiologically-based
pharmacokinetic
(PBPK)
models
provided,
limitations
our
current
knowledge
about
vitro
vivo
restrict
development
robust
PBPK
also
discussed.
hypothesized
assessment
whole-body
mathematical
can
predict
their
disposition
improve
probability
successful
clinical
translation
these
modalities.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1010 - 1010
Published: March 2, 2022
Clinically
available
medications
face
several
hurdles
that
limit
their
therapeutic
activity,
including
restricted
access
to
the
target
tissues
due
biological
barriers,
low
bioavailability,
and
poor
pharmacokinetic
properties.
Drug
delivery
systems
(DDS),
such
as
nanoparticles
(NPs)
hydrogels,
have
been
widely
employed
address
these
issues.
Furthermore,
DDS
improves
drugs’
efficacy
while
reducing
undesired
side
effects
caused
by
unspecific
distribution
over
different
tissues.
The
integration
of
NPs
into
hydrogels
has
emerged
improve
performance
when
compared
with
each
individually.
combination
both
enhances
ability
deliver
drugs
in
a
localized
targeted
manner,
paired
controlled
sustained
drug
release,
resulting
increased
effectiveness.
With
incorporation
it
is
possible
apply
locally
then
provide
release
site
action,
allowing
uptake
required
location.
Additionally,
most
materials
used
produce
present
toxicity.
This
article
provides
systematic
review
polymeric
NPs-loaded
developed
for
various
biomedical
applications,
focusing
on
studies
vivo
data.
Journal of Composites Science,
Journal Year:
2023,
Volume and Issue:
7(1), P. 24 - 24
Published: Jan. 10, 2023
Shape
memory
polymers
(SMPs)
are
emerging
smart
materials
that
have
the
ability
to
change
a
shape
and
revert
their
permanent
on
application
of
external
stimulus.
SMPs
can
be
divided
into
four
types
based
shape,
elasticity
origin,
temporary
fixing
mechanism:
chemically
cross-linked
glassy
thermosets,
semi-crystalline,
physically
copolymers,
block
copolymers.
The
broad
overview
recent
developments
for
biomedical
applications
proves
wide
applicability
in
field
general
medicine,
drug
delivery,
regenerative
dentistry,
neuromedicine,
cancer
therapy,
orthopedics,
corrosion
protection.
Herein,
comprehensive
analysis
composites
with
focus
types,
mechanism,
functionality
is
presented.
Relevant
technologies
future
advancement
towards
also
discussed.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 206 - 221
Published: March 21, 2024
With
the
development
of
nanomedicine,
nanomaterials
have
been
widely
used,
offering
specific
drug
delivery
to
target
sites,
minimal
side
effects,
and
significant
therapeutic
effects.
The
kidneys
filtration
reabsorption
functions,
with
various
potential
cell
types
a
complex
structural
environment,
making
strategies
for
kidney
function
protection
recovery
after
injury
complex.
This
also
lays
foundation
application
nanomedicine
in
diseases.
Currently,
evidence
preclinical
clinical
settings
supports
feasibility
targeted
therapy
diseases
using
based
on
nanomaterials.
prerequisite
treating
is
use
carriers
good
biocompatibility,
including
nanoparticles,
hydrogels,
liposomes,
micelles,
dendrimer
polymers,
adenoviruses,
lysozymes,
elastin-like
polypeptides.
These
precise
renal
uptake,
longer
half-life,
organ
distribution,
protecting
improving
efficacy
drugs
they
carry.
Additionally,
attention
should
be
paid
toxicity
solubility
carriers.
While
mentioned
above
used
studies
both
vivo
vitro,
extensive
trials
are
still
needed
ensure
short-term
long-term
effects
nano
human
body.
review
will
discuss
advantages
limitations
nanoscale
carrier
materials
diseases,
provide
more
comprehensive
catalog
nanocarrier
materials,
offer
prospects
their
drug-loading
applications.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 421 - 421
Published: Feb. 15, 2022
Polymers
that
can
change
their
properties
in
response
to
an
external
or
internal
stimulus
have
become
interesting
platform
for
drug
delivery
systems.
Polymeric
nanoparticles
be
used
decrease
the
toxicity
of
drugs,
improve
circulation
hydrophobic
and
increase
a
drug’s
efficacy.
Furthermore,
polymers
are
sensitive
specific
stimuli
achieve
controlled
release
drugs
into
areas
body.
This
review
discusses
different
based
on
stimuli.
Internal
been
defined
as
events
evoke
changes
characteristics,
inside
body,
such
pH,
redox
potential,
temperature.
External
use
source
light
ultrasound
implement
changes.
Special
attention
has
paid
particular
chemical
structures
need
incorporated
desired
response.
A
current
trend
this
field
is
incorporation
several
single
polymer
higher
specificity.
Therefore,
access
most
recent
advances
stimuli-responsive
polymers,
focus
combine
The
combination
discussed
along
with
produce
it.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(22), P. 12431 - 12470
Published: Oct. 31, 2023
Fluorinated
polymeric
nanoparticles
(FPNPs)
combine
unique
properties
of
fluorocarbon
and
nanoparticles,
which
has
stimulated
massive
interest
for
decades.
However,
fluoropolymers
are
not
readily
available
from
nature,
resulting
in
synthetic
developments
to
obtain
FPNPs
via
free
radical
polymerizations.
Recently,
while
increasing
cutting-edge
directions
demand
tailored
FPNPs,
such
materials
have
been
difficult
access
conventional
approaches.
Reversible-deactivation
polymerizations
(RDRPs)
powerful
methods
afford
well-defined
polymers.
Researchers
applied
RDRPs
the
fabrication
enabling
construction
particles
with
improved
complexity
terms
structure,
composition,
morphology,
functionality.
Related
examples
can
be
classified
into
three
categories.
First,
synthesized
utilized
as
precursors
form
through
self-folding
solution
self-assembly.
Second,
thermally
photoinitiated
explored
realize
situ
preparations
varied
morphologies
polymerization-induced
self-assembly
cross-linking
copolymerization.
Third,
grafting
inorganic
investigated
based
on
RDRPs.
Importantly,
those
advancements
promoted
studies
toward
promising
applications,
including
magnetic
resonance
imaging,
biomedical
delivery,
energy
storage,
adsorption
perfluorinated
alkyl
substances,
photosensitizers,
so
on.
This
Review
should
present
useful
knowledge
researchers
polymer
science
nanomaterials
inspire
innovative
ideas
synthesis
applications
FPNPs.
