Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk DOI Creative Commons
Elena Vianello, Federico Ambrogi, Marta Kalousová

et al.

Experimental and Molecular Pathology, Journal Year: 2024, Volume and Issue: 137, P. 104895 - 104895

Published: May 3, 2024

Lipidome perturbation occurring during meta-inflammation is associated to left ventricle (LV) remodeling though the activation of NLRP3 inflammasome, a key regulator chronic inflammation in obesity-related disorders. Little known about phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as DAMP-induced inflammasome. Our study aimed evaluate if systemic reduction PC/PE molar ratio can affect plasma levels cardiovascular disease (CVD) patients with insulin resistance (IR) risk. Forty from IRCCS Policlinico San Donato were enrolled, their blood samples drawn before heart surgery. LV geometry measurements evaluated by echocardiography clinical data IR risk collected. PC PE quantified ESI-MS/MS. Circulating was an ELISA assay. results have shown that CVD presented lipid impairment species inversely levels. Interestingly, changes directly increased decrease plasma, highlighting effect cardiac response. In summary, be considered bioactive mediators both

Language: Английский

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy DOI Creative Commons
Jiatong Liu, Xiaoyue Han,

Tingyue Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 30, 2023

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses associated with most human diseases. Reactive oxygen species (ROS) are class chemicals that generated after incomplete reduction molecular oxygen. At moderate levels, ROS function as critical signaling molecules in modulation various physiological functions, including responses. However, at excessive exert toxic effects and directly oxidize biological macromolecules, such proteins, nucleic acids lipids, further exacerbating development causing Therefore, designing manufacturing biomaterials scavenge has emerged an important approach for restoring homeostasis, limiting protecting host against damage. This review systematically outlines dynamic balance production clearance under conditions. We focus on mechanisms by which regulate cell proteins how these affect inflammation. Furthermore, we discuss use potential currently available-biomaterials ROS, agents were engineered reduce levels blocking generation, chemically reacting or catalytically accelerating clearance, treatment Finally, evaluate challenges prospects controlled material design scavenging biomaterials.

Language: Английский

Citations

194
Food Anthocyanins: Malvidin and Its Glycosides as Promising Antioxidant and Anti-Inflammatory Agents with Potential Health Benefits DOI Open Access
Anna Merecz-Sadowska, Przemysław Sitarek, Tomasz Kowalczyk

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 3016 - 3016

Published: July 1, 2023

Anthocyanins are flavonoid compounds that abundantly present in fruits and vegetables. These contribute to the color of these foods offer various health benefits consumers due their biological properties. There more than 1000 types anthocyanins nature, all derived from 27 anthocyanidin aglycones have different glycosylations acylations. Malvidin is one most well-known anthocyanidins. Several studies, including those conducted on cell lines, animals, humans, suggested malvidin its glycosides possess anti-carcinogenic, diabetes-control, cardiovascular-disease-prevention, brain-function-improvement primarily attributed antioxidant anti-inflammatory effects, which influenced by molecular mechanisms related expression modulation critical genes. In this article, we review available information activity concerning health-promoting effects.

Language: Английский

Citations

58
Mitochondrial Reactive Oxygen Species in Infection and Immunity DOI Creative Commons
Arunima Mukherjee, Krishna Ghosh, Sabyasachi Chakrabortty

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 670 - 670

Published: June 8, 2024

Reactive oxygen species (ROS) contain at least one atom and or more unpaired electrons include singlet oxygen, superoxide anion radical, hydroxyl hydroperoxyl free nitrogen radicals. Intracellular ROS can be formed as a consequence of several factors, including ultra-violet (UV) radiation, electron leakage during aerobic respiration, inflammatory responses mediated by macrophages, other external stimuli stress. The enhanced production is termed oxidative stress this leads to cellular damage, such protein carbonylation, lipid peroxidation, deoxyribonucleic acid (DNA) base modifications. This damage may manifest in various pathological states, ageing, cancer, neurological diseases, metabolic disorders like diabetes. On the hand, optimum levels have been implicated regulation many important physiological processes. For example, generated mitochondria (mitochondrial mt-ROS), byproduct transport chain (ETC), participate plethora functions, which cell growth, proliferation, immune response regulation. In current review, we will focus on mechanisms mt-ROS regulate different pathways host context infection bacteria, protozoan parasites, viruses, fungi. We also discuss how these pathogens, turn, modulate evade immunity. conclude briefly giving an overview potential therapeutic approaches involving infectious diseases.

Language: Английский

Citations

16
Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders DOI Creative Commons
Guangming Zhang,

Huayuan Wei,

Anliu Zhao

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 7, 2025

Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.

Language: Английский

Citations

3
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis DOI
Hardeep Singh Tuli, Jagjit Kaur,

Kanupriya Vashishth

et al.

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 103 - 120

Published: Nov. 28, 2022

Language: Английский

Citations

57
Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics DOI Creative Commons
Yueran Cui,

Haiyang Yu,

Zhongqi Bu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: May 25, 2022

Neuroinflammation is initiated with an aberrant innate immune response in the central nervous system (CNS) and involved many neurological diseases. Inflammasomes are intracellular multiprotein complexes that can be used as platforms to induce maturation secretion of proinflammatory cytokines pyroptosis, thus playing a pivotal role neuroinflammation. Among inflammasomes, nucleotide-binding oligomerization domain-, leucine-rich repeat- pyrin domain-containing 3 (NLRP3) inflammasome well-characterized contributes diseases, such multiple sclerosis (MS), Alzheimer's disease (AD), ischemic stroke. MS chronic autoimmune CNS, its hallmarks include inflammation, demyelination, neurodegeneration. Studies have demonstrated relationship between NLRP3 inflammasome. To date, pathogenesis not fully understood, clinical studies on novel therapies still underway. Here, we review activation mechanism inflammasome, MS, targeting related molecules, which may beneficial MS.

Language: Английский

Citations

41
Molybdenum and cadmium cause blood–testis barrier dysfunction through ROS-mediated NLRP3 inflammasome activation in sheep DOI
Lu Jiang, Fan Yang, Huan Liao

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167267 - 167267

Published: Sept. 22, 2023

Language: Английский

Citations

39
Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages DOI
Chia George Hsu, Wenjia Li, Mark P. Sowden

et al.

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(2), P. 131 - 142

Published: Jan. 4, 2023

Language: Английский

Citations

33
Emerging factors affecting peri‐implant bone metabolism DOI Creative Commons
Ángel Ínsua, Pablo Galindo‐Moreno, Richard J. Miron

et al.

Periodontology 2000, Journal Year: 2023, Volume and Issue: 94(1), P. 27 - 78

Published: Oct. 30, 2023

Abstract Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This attributed in part advancements material sciences have led toward improvements surface technology and characteristics. Nonetheless, there remain several cases where therapy fails (specifically at early time points), most commonly factors affecting bone metabolism. Among these patients, smokers are known impaired metabolism thus be subject higher risks of failure and/or late complications related stability peri‐implant mucosal tissues. Notably, however, emerging data unveiled other critical osseointegration, namely, those The aim this review shed light on effects implant‐related factors, like or titanium particle release; surgical‐related osseodensification implanted biomaterials; various drugs, selective serotonin reuptake inhibitors, proton pump anti‐hypertensives, nonsteroidal anti‐inflammatory medication, statins, host‐related smoking, diet, metabolic syndrome metabolism, aseptic loss. Despite infectious nature biological complications, must surveyed for effective prevention management peri‐implantitis.

Language: Английский

Citations

29
Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model DOI
Tarek K. Motawi,

Shohda A. El‐Maraghy,

Ahmed S. Kamel

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 209, P. 115435 - 115435

Published: Jan. 30, 2023

Language: Английский

Citations

26