Bacterial motility: machinery and mechanisms

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(3), P. 161 - 173

Published: Sept. 21, 2021

Language: Английский

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Neisseria gonorrhoeae host adaptation and pathogenesis

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(4), P. 226 - 240

Published: Feb. 12, 2018

Language: Английский

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A comprehensive guide to pilus biogenesis in Gram-negative bacteria

Nature Reviews Microbiology, Journal Year: 2017, Volume and Issue: 15(6), P. 365 - 379

Published: May 12, 2017

Language: Английский

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A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

Nature Reviews Microbiology, Journal Year: 2017, Volume and Issue: 15(3), P. 149 - 159

Published: Jan. 16, 2017

Language: Английский

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How Bacteria Use Type IV Pili Machinery on Surfaces

Trends in Microbiology, Journal Year: 2015, Volume and Issue: 23(12), P. 775 - 788

Published: Oct. 25, 2015

Language: Английский

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Tree of motility – A proposed history of motility systems in the tree of life

Genes to Cells, Journal Year: 2020, Volume and Issue: 25(1), P. 6 - 21

Published: Jan. 1, 2020

Abstract Motility often plays a decisive role in the survival of species. Five systems motility have been studied depth: those propelled by bacterial flagella, eukaryotic actin polymerization and motor proteins myosin, kinesin dynein. However, many organisms exhibit surprisingly diverse motilities, advances genomics, molecular biology imaging showed that motilities inherently independent mechanisms. This makes defining breadth nontrivial, because novel may be driven unknown Here, we classify known based on unique classes movement‐producing protein architectures. Based this criterion, current total stands at 18 types. In perspective, discuss these modes relative to latest phylogenetic Tree Life propose history motility. During ~4 billion years since emergence life, arose Bacteria with flagella pili, Archaea archaella. Newer became possible Eukarya changes cell envelope. Presence or absence peptidoglycan layer, acquisition robust membrane dynamics, enlargement cells environmental opportunities likely provided context for (co)evolution types

Language: Английский

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Diversification of the type IV filament superfamily into machines for adhesion, protein secretion, DNA uptake, and motility

PLoS Biology, Journal Year: 2019, Volume and Issue: 17(7), P. e3000390 - e3000390

Published: July 19, 2019

Processes of molecular innovation require tinkering and shifting in the function existing genes. How this occurs terms evolution at long evolutionary scales remains poorly understood. Here, we analyse natural history a vast group membrane-associated systems Bacteria Archaea-the type IV filament (TFF) superfamily-that diversified involved flagellar or twitching motility, adhesion, protein secretion, DNA uptake. The phylogeny thousands detected suggests they may have been present last universal common ancestor. From there, two lineages-a bacterial an archaeal-diversified by multiple gene duplications, fissions deletions, accretion novel components. Surprisingly, find that 'tight adherence' (Tad) originated from interkingdom transfer Archaea to system resembling 'EppA-dependent' (Epd) pilus were associated with acquisition secretin. content ancestral suggest initial pili engaged cell motility and/or In contrast, specialised secretion arose several times independently much later history. functional diversification TFF superfamily was accompanied genetic rearrangements implications for regulation horizontal transfer: encoded fewer loci more frequently exchanged between taxa. This contributed their rapid spread across Archaea. Hence, reveals impressive catalogue mechanisms resulted remarkable specialisation relatively small set

Language: Английский

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Cytokine Storm—Definition, Causes, and Implications

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11740 - 11740

Published: Oct. 3, 2022

The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, numerous other mediators). Usually, a fragile equilibrium pro- anti-inflammation effects is maintained by complex regulatory mechanisms. Disturbances this homeostasis can lead to intricate chain reactions resulting in massive release cytokines. This may result drastic self-reinforcement various feedback mechanisms, which ultimately systemic damage, multi-organ failure, or death. Not only pathogens initiate such disturbances, but also congenital diseases immunomodulatory therapies. Due the diverse interactions within systems, understanding important clinical syndrome incomplete date effective therapeutic approaches remain scarce.

Language: Английский

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Electrically conductive pili: Biological function and potential applications in electronics

Current Opinion in Electrochemistry, Journal Year: 2017, Volume and Issue: 4(1), P. 190 - 198

Published: Aug. 1, 2017

Language: Английский

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The molecular mechanism of the type IVa pilus motors

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: May 5, 2017

Abstract Type IVa pili are protein filaments essential for virulence in many bacterial pathogens; they extend and retract from the surface of cells to pull bacteria forward. The motor ATPase PilB powers pilus assembly. Here we report structures core domains Geobacter metallireducens bound ADP non-hydrolysable ATP analogue, AMP-PNP, at 3.4 2.3 Å resolution, respectively. These reveal important differences nucleotide binding between chains. Analysis these reveals sequential turnover nucleotide, corresponding domain movements. Our data suggest a clockwise rotation central sub-pores PilB, which through interactions with PilC, would support assembly right-handed helical pilus. analysis also suggests counterclockwise C2 symmetric PilT that enable disassembly. proposed model provides insight into how this family ATPases can power extension retraction.

Language: Английский

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