Advances in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6578 - 6578

Published: March 31, 2023

Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant disease, characterized by multiple organ damage, that in its most severe forms can be life-threatening. The pathogenesis of SLE complex and involves cells both innate adaptive immunity. distinguishing feature the production autoantibodies, with formation immune complexes precipitate at vascular level, causing damage. Although progress understanding has been slower than other rheumatic diseases, new knowledge recently led to development effective targeted therapies, hold out hope for personalized therapy. However, drugs available date are still an adjunct conventional therapy, which known toxic short long term. purpose this review summarize recent advances disease discuss results obtained from use drugs, look future therapies may used absence current standard care or even cure serious systemic autoimmune disease.

Language: Английский

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COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

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Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer

Cytokine, Journal Year: 2023, Volume and Issue: 171, P. 156376 - 156376

Published: Sept. 23, 2023

Language: Английский

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Biochemical aspects of the inflammatory process: A narrative review

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115764 - 115764

Published: Oct. 26, 2023

Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, even autoimmune reactions. The cardinal signs inflammation are consequences immunological, biochemical, and physiological changes that trigger release pro-inflammatory chemical mediators at local injured site thus, increasing blood flow, vascular permeability, leukocyte recruitment. aim this study to give an overview inflammatory process, focusing on mediators. literature review was based search journals published between years 2009 2023, regarding role major in process current studies pathogenesis, diagnosis, therapy. Some recent contributions pathologies their mediators, including cytokines chemokines, kinin system, free radicals, nitric oxide, histamine, cell adhesion molecules, leukotrienes, prostaglandins complement system human health chronic diseases.

Language: Английский

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PANoptosis: Emerging mechanisms and disease implications

Life Sciences, Journal Year: 2023, Volume and Issue: 333, P. 122158 - 122158

Published: Oct. 6, 2023

Language: Английский

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Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 545 - 545

Published: April 24, 2024

SARS-CoV-2, the causative agent of ongoing COVID-19 pandemic, has revealed a broader impact beyond respiratory system, predominantly affecting vascular system with various adverse manifestations. The infection induces endothelial dysfunction and immune dysregulation, creating an inflammatory hypercoagulable state. It affects both microvasculature macrovasculature, leading to thromboembolic events, cardiovascular manifestations, impaired arterial stiffness, cerebrovascular complications, nephropathy, as well retinopathy-frequently observed in cases severe illness. Evidence suggests that SARS-CoV-2 may result persistent effects on identified long-term COVID-19. This is characterized by prolonged inflammation, endotheliopathy, increased risk complications. Various imaging modalities, histopathological studies, diagnostic tools such video capillaroscopy magnetic resonance have been employed visualize alterations. review aims comprehensively summarize evidence concerning short alterations following infection, investigating their patients' prognosis, providing overview preventive strategies mitigate associated

Language: Английский

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Injectable hydrogel-based combination therapy for myocardial infarction: a systematic review and Meta-analysis of preclinical trials

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 21, 2024

Abstract Introduction This study evaluates the effectiveness of a combined regimen involving injectable hydrogels for treatment experimental myocardial infarction. Patient concerns Myocardial infarction is an acute illness that negatively affects quality life and increases mortality rates. Experimental models can aid in disease research by allowing development therapies effectively manage progression promote tissue repair. Diagnosis animal were established using ligation method on anterior descending branch left coronary artery (LAD). Interventions The efficacy intracardiac injection hydrogels, with cells, drugs, cytokines, extracellular vesicles, or nucleic acid therapies, was evaluated to assess functional morphological improvements post-infarction heart achieved through hydrogel regimen. Outcomes A literature review conducted PubMed, Web Science, Scopus, Cochrane databases. total 83 papers, including studies 1332 animals (rats, mice, rabbits, sheep, pigs), included meta-analysis based inclusion exclusion criteria. overall effect size observed group receiving therapy, compared alone, resulted ejection fraction (EF) improvement 8.87% [95% confidence interval (CI): 7.53, 10.21] fractional shortening (FS) 6.31% CI: 5.94, 6.67] rat models, while mice 16.45% 11.29, 21.61] EF 5.68% 5.15, 6.22] FS. most significant (rats: MD = 9.63% 4.02, 15.23]; mice: 23.93% 17.52, 30.84]) FS 8.55% 2.54, 14.56]; 6.22]) when vesicle therapy used. Although there have been results large experiments, number this area limited. Conclusion present demonstrates combining other improves function morphology. Further preclinical necessary additional validation. Graphical abstract

Language: Английский

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Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 20, 2024

Background Autoimmune thyroid disease (AITD) ranks among the most prevalent diseases, with inflammatory cytokines playing a decisive role in its pathophysiological process. However, causal relationship between and AITD remains elusive. Methods A two-sample Mendelian randomization (MR) analysis was performed to elucidate connection 41 cytokines. Genetic variations associated were sourced from FinnGen biobank, whereas comprehensive meta-analysis of genome-wide association studies (GWASs) yielded data on Graves’ (GD) Hashimoto thyroiditis. Regarding MR analysis, inverse variance-weighted, MR-Egger, weighted median methods utilized. Additionally, sensitivity conducted using MR-Egger regression, MR-pleiotropy residual sum, outliers. Results Seven associations identified AITD. High levels tumor necrosis factor–β low stem cell growth indicative higher risk GD. In contrast, high interleukin-12p70 (IL-12p70), IL-13, interferon-γ monocyte chemotactic protein–1 (MCP-1) TNF-α suggested HD. Moreover, 14 detected GD increases macrophage protein–1β, MCP-1, monokine induced by (MIG), interferon γ–induced protein 10 (IP-10), stromal cell–derived factor–1α, platelet-derived factor BB, β–nerve factor, IL-2ra, IL-4, IL-17 blood, HD MIG, IP-10, IL-16 levels. Conclusion Our bidirectional revealed These findings offer valuable insights into mechanisms underlying

Language: Английский

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Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 2, 2025

To investigate the anti-inflammatory effects of collagen peptides, peptides from cod skin were prepared to assess their in vitro and vivo efficacy against ulcerative colitis. The results show that demonstrated by inhibiting secretion pro-inflammatory cytokines reducing oxidative stress vitro. In vivo, significantly reduced colonic tissue damage, modulated serum cytokine balance, increased expression tight junction proteins ZO-1, Occludin, Claudin-1 colon tissue, enhanced abundance beneficial bacteria while harmful bacteria, restored microbial balance. addition, ameliorated colitis phosphorylation NF-κB p65, IκBα p38 MAPK NF-κB/MAPK signaling pathway. Based on these findings, could serve as potential therapeutic agents for managing

Language: Английский

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A comparative study of the genetically improved Abbassa Nile tilapia strain (GIANT-G9) and a commercial strain in Egypt: growth vs. stress response

Veterinary Research Communications, Journal Year: 2025, Volume and Issue: 49(2)

Published: Jan. 14, 2025

Selective breeding is a potent method for developing strains with enhanced traits. This study compared the growth performance and stress responses of genetically improved Abbassa Nile tilapia strain (G9; GIANT-G9) local commercial over 12 weeks, followed by exposure to stressors including high ammonia (10 mg TAN/L), elevated temperature (37 °C), both three days. The GIANT-G9 showed superior growth, greater weight gain, final weight, length specific rate, protein efficiency ratio, as well lower feed conversion ratio condition factor strain. expression hormone in brain increased significantly after 6 although it slightly decreased weeks. Growth receptor 1 also Muscle insulin-like factors (igf1 igf2) levels up-regulated only weeks GIANT-G9. Under stress, serum enzymes (alanine aminotransferase, aspartate alkaline phosphatase (ALP)) were higher GIANT-G9, while had levels. No significant changes observed liver ALP activity among stressed strains. exhibited marked upregulation splenic Toll-like receptors (tlr2, tlr9, tlr21), myeloid differentiation primary response 88 (myd88), nuclear kappa B (nf-κB), interleukin (il) 1β, il6. Notably, il6 was than il1β spleen, opposite pattern head kidney. In immune stimulation, globulin but similar values Myostatin spleen best catalase superoxide dismutase activities under glutathione-S-transferase (GST) stress. Serum lysozyme other conditions. Overall, demonstrated survivability revealed interactions between factors. rates antioxidant capacities at juvenile stage life production cycle.

Language: Английский

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